Sex differences in the cerebral BOLD signal response to painful heat stimuli

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 291, Issue 2, 2006, Pages

  Moulton, Eric A ^a   Keaser, Michael L ^a   Gullapalli, Rao P ^a,b   Maitra, Ranjan ^c   Greenspan, Joel D ^a,d  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MARYLAND MEDICAL CENTER   (United States)

^c Department of Statistics Center for Statistics and Applications in Forensic Evidence Iowa State University 2438 Osborn Dr Ames   (United States)

^d UNIVERSITY OF MARYLAND DENTAL SCHOOL   (United States)

Author keywords

fMRI; Negative blood oxygenation level dependent signal; Neuroimaging; Nociception; Prefrontal cortex; Somatosensory cortex

Indexed keywords

ADULT; ARTICLE; BRAIN BLOOD FLOW; CONTROLLED STUDY; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HUMAN; HUMAN EXPERIMENT; MALE; NEUROIMAGING; NOCICEPTION; OXYGEN BLOOD LEVEL; PAIN; PAIN ASSESSMENT; PREFRONTAL CORTEX; PRIORITY JOURNAL; SEX DIFFERENCE; SOMATOSENSORY CORTEX; THERMAL STIMULATION;

ADULT; BRAIN MAPPING; CEREBRAL CORTEX; EVOKED POTENTIALS; FEMALE; HEAT; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; OXYGEN; PAIN; PAIN MEASUREMENT; PHYSICAL STIMULATION; SEX CHARACTERISTICS;

EID: 33745825501     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00084.2006     Document Type: Article

References (34)

1. Becerra LR, Comite AR, Breiter H, Gonzalez RG, and Borsook D. Differential CNS activation following a noxious thermal stimulus in men and women: an fMRI study (Abstract). Soc Neurosci Abstr 24: 1136, 1998.
2. Berman KF, Schmidt PJ, Rubinow DR, Danaceau MA, Van Horn JD, Esposito G, Ostrem JL, and Weinberger DR. Modulation of cognition-specific cortical activity by gonadal steroids: a positron-emission tomography study in women. Proc Natl Acad Sci USA 94: 8836-8841, 1997.
3. Berman S, Munakata J, Naliboff BD, Chang L, Mandelkern M, Silverman D, Kovalik E, and Mayer EA. Gender differences in regional brain response to visceral pressure in IBS patients. Eur J Pain 4: 157-172, 2000.
4. Berman SM, Naliboff BD, Suyenobu B, Labus JS, Stains J, Bueller JA, Ruby K, and Mayer EA. Sex differences in regional brain response to aversive pelvic visceral stimuli. Am J Physiol Regul Integr Comp Physiol 291: R268-R276, 2006.
5. Bishop J and Simpkins JW. Estradiol enhances brain glucose uptake in ovariectomized rats. Brain Res Bull 36: 315-320, 1995.
6. 15O]water studies with 6-minute and 10-minute interscan intervals: single-subject and group analyses. J Cereb Blood Flow Metab 19: 570-582, 1999.
7. Derbyshire SWG, Nichols TE, Firestone L, Townsend DW, and Jones AKP. Gender differences in patterns of cerebral activation during equal experience of painful laser stimulation*1. J Pain 3: 401-411, 2002.
8. Fillingim RB. Sex, Gender, and Pain. Seattle, WA: IASP, 2001.
9. Fillingim RB, Keefe FJ, Light KC, Booker D, and Maixner W. The influence of gender and psychological factors on pain perception. J Gender Cult Health 1: 21-36, 1996.
10. Fillingim RB and Maixner W. Gender differences in the response to noxious stimuli. Pain Forum 4: 209-221, 1995.
11. Green BG and Cruz A. "Warmth-insensitive fields": evidence of sparse and irregular innervation of human skin by the warmth sense. Somatosens Mot Res 15: 269-275, 1998.
12. Greenspan JD, Moulton EA, Keaser ML, and Gullapalli RP. Sex differences in the BOLD signal response to painful heat stimuli (Abstract). 11th World Congress on Pain, Sydney, Australia, Program #486-P92, 2005.
13. Greicius MD and Menon V. Default-mode activity during a passive sensory task: Uncoupled from deactivation but impacting activation. J Cognit Neurosci 16: 1484-1492, 2004.
14. Gur RC, Mozley LH, Mozley PD, Resnick SM, Karp JS, Alavi A, Arnold SE, and Gur RE. Sex differences in regional cerebral glucose metabolism during a resting state. Science 267: 528-531, 1995.
15. Gur RE and Gur RC. Gender differences in regional cerebral blood flow. Schizophr Bull 16: 247-254, 1990.
16. Hedera P, Wu D, Collins S, Lewin JS, Miller D, Lerner AJ, Klein S, and Friedland RP. Sex and electroencephalographic synchronization after photic stimulation predict signal changes in the visual cortex on functional MR images. AJNR Am J Neuroradiol 19: 853-857, 1998.
17. Kastrup A, Li TQ, Krüger G, Glover GH, and Moseley ME. Relationship between cerebral blood flow changes during visual stimulation and baseline flow levels investigated with functional MRI. Neuroreport 10: 1751-1756, 1999.
18. Kaufmann C, Elbel GK, Gössl C, Pütz B, and Auer DP. Frequency dependence and gender effects in visual cortical regions involved in temporal frequency dependent pattern processing. Hum Brain Mapp 14: 28-38, 2001.
19. Levin JM, Ross MH, Mendelson JH, Mello NK, Cohen BM, and Renshaw PF. Sex differences in blood-oxygenation-level-dependent functional MRI with primary visual stimulation. Am J Psychiatry 155: 434-436, 1998.
20. Mogil JS, Chesler EJ, Wilson SG, Juraska JM, and Sternberg WF. Sex differences in thermal nociception and morphine antinociception in rodents depend on genotype. Neurosci Biobehav Rev 24: 375-389, 2000.
21. Moulton EA, Keaser ML, Gullapalli RP, and Greenspan JD. Regional intensive and temporal patterns of functional MRI activation distinguishing noxious and innocuous contact heat. J Neurophysiol 93: 2183-2193, 2005.
22. Moulton EA, Keaser ML, Gullapalli RP, and Greenspan JD. Sex differences in the BOLD signal response to painful heat stimuli (Abstract). 11th Annual Human Brain Mapping Meeting, Toronto, Canada, #1438, 2005.
23. Naliboff B, Berman S, Chang L, Derbyshire S, Suyenobu B, Vogt B, Mandelkern M, and Mayer E. Sex-related differences in IBS patients: central processing of visceral stimuli. Gastroenterology 124: 1738-1747, 2003.
24. Namba H and Sokoloff L. Acute administration of high doses of estrogen increases glucose utilization throughout brain. Brain Res 291: 391-394, 1984.
25. Paulson PE, Minoshima S, Morrow TJ, and Casey KL. Gender differences in pain perception and patterns of cerebral activation during noxious heat stimulation in humans. Pain 76: 223-229, 1998.
26. Porro CA, Cettolo V, Francescato MP, and Baraldi P. Temporal and intensity coding of pain in human cortex. J Neurophysiol 80: 3312-3320, 1998.
27. Resnick SM, Maki PM, Golski S, Kraut MA, and Zonderman AB. Effects of estrogen replacement therapy on PET cerebral blood flow and neuropsychological performance. Horm Behav 34: 171-182, 1998.
28. Riley JL III, Robinson ME, Wise EA, Myers CD, and Fillingim RB. Sex differences in the perception of noxious experimental stimuli: a meta-analysis. Pain 74: 181-187, 1998.
29. Rodriguez G, Warkentin S, Risberg J, and Rosadini G. Sex differences in regional cerebral blood flow. J Cereb Blood Flow Metab 8: 783-789, 1988.
30. Rollman GB, Abdel-Shaheed J, Gillespie JM, and Jones KS. Does past pain influence current pain: biological and psychosocial models of sex differences. Eur J Pain 8: 427-433, 2004.
31. Shmuel A, Yacoub E, Pfeuffer J, Van de Moortele PF, Adriany G, Hu X, and Ugurbil K. Sustained negative BOLD, blood flow and oxygen consumption response and its coupling to the positive response in the human brain. Neuron 36: 1195-1210, 2002.
32. Shulman RG, Rothman DL, Behar KL, and Hyder F. Energetic basis of brain activity: implications for neuroimaging. Trends Neurosci 27: 489-495, 2004.
33. Smith AT, Williams AL, and Singh KD. Negative BOLD in the visual cortex: evidence against blood stealing. Hum Brain Mapp 21: 213-220, 2004.
34. Talairach J and Tournoux P. Co-planar stereotaxic atlas of the human brain: 3D proportional system: an approach to cerebral imaging. Stuttgart, Germany: Georg Thieme Verlag, 1988.