An NMR relaxometry and gravimetric study of gelatin-free aqueous polyacrylamide dosimeters

Physics in Medicine and Biology

Volumn 51, Issue 17, 2006, Pages 4171-4187

  Babic, Steven ^a,b,c   Schreiner, L John ^a,b  

^a KINGSTON GENERAL HOSPITAL   (Canada)

^b QUEEN S UNIVERSITY   (Canada)

^c LONDON REGIONAL CANCER PROGRAM   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

OPTICAL COMPUTED TOMOGRAPHY; POLYACRYLAMIDE GELATIN (PAG); RELAXATION MEASUREMENTS; RELAXOMETRY;

COMPUTERIZED TOMOGRAPHY; GRAVIMETRIC ANALYSIS; IRRADIATION; NUCLEAR MAGNETIC RESONANCE; POLYMERIZATION; POLYMERS; RADIOTHERAPY; RELAXATION PROCESSES;

DOSIMETERS;

COBALT 60; GELATIN; POLYACRYLAMIDE;

ARTICLE; CANCER RADIOTHERAPY; CONFORMAL RADIATION THERAPY; DOSIMETER; DOSIMETRY; GAS CHROMATOGRAPHY; GRAVIMETRY; IRRADIATION; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE RELAXOMETRY; POLYMERIZATION; PRIORITY JOURNAL; RADIATION DOSE;

ACRYLAMIDES; ACRYLIC RESINS; GELATIN; GRAVITATION; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; OPTICS; OPTICS AND PHOTONICS; PROTONS; RADIOMETRY; SENSITIVITY AND SPECIFICITY; TOMOGRAPHY, X-RAY COMPUTED; WATER;

EID: 33745824859     PISSN: 00319155     EISSN: 13616560     Source Type: Journal    
DOI: 10.1088/0031-9155/51/17/004     Document Type: Article

References (38)

1. Audet C 1995 Studies of the gel systems used for 3D MRI dosimetry PhD Thesis McGill University, Montreal, PQ
2. Audet C and Schreiner L J 1997 Multiple-site fast exchange model for spin-lattice relaxation in the Fricke-gelatin dosimeter Med. Phys. 24 201-9
3. Baldock C, Rintoul L, Keevil S F, Pope J M and George G A 1998 Fourier transform Raman spectroscopy of polyacrylamide gels (PAGs) for radiation dosimetry Phys. Med. Biol. 43 3617-27
4. Bloombergen N, Purcell E M and Pound R V 1948 Relaxation effects in nuclear magnetic resonance absorption Phys. Rev. 73 679-712
5. DeDeene Y, Hanselaer P, DeWagter C, Achten E and DeNeve W 2000 An investigation of the chemical stability of a monomer/polymer gel dosimeter Phys. Med. Biol. 45 859-78
6. DeDeene Y, Venning A, Hurley C, Healy B J and Baldock C 2002 Dose-response stability and integrity of the dose distribution of various polymer gel dosimeters Phys. Med. Biol. 47 2459-70
7. DeDeene Y, Vergote K, Claeys C and DeWagter C 2006 The fundamental radiation properties of normoxic polymer gel dosimeters: a comparison between a methacrylic acid based gel and acrylamide based gels Phys. Med. Biol. 51 653-73
8. Fuxman A, McAuley K B and Schreiner L J 2003 Modeling of free-radical crosslinking copolymerization of acrylamide and N,N′- methylenebis(acrylamide) for radiation dosimetry Macromol. Theory Simul. 12 647-62
9. Gelfi C and Righetti P G 1981 Polymerization kinetics of polyacrylamide gels Electrophoresis 2 213-28
10. Gore J C, Kang Y S and Schulz R J 1984 Measurement of radiation dose distributions by nuclear magnetic resonance (NMR) imaging Phys. Med. Biol. 29 1189-97
11. Hepworth S J, Leach M O and Doran S J 1999 Dynamics of polymerization in polyacrylamide gel (PAG) dosimeters: (II) modelling oxygen diffusion Phys. Med. Biol. 44 1875-84
12. Ibbott G S, Maryanski M J, Eastman P, Holcomb M S, Zhang M S, Avison R T, Sanders M S and Gore J C 1997 Three-dimensional visualization and measurement of conformal dose distributions using magnetic resonance imaging of BANG polymer gel dosimeters Int. J. Radiat. Oncol. Biol. Phys. 38 1097-103
13. Jirasek A I and Duzenli C 2001 Effects of crosslinker fraction in polymer gel dosimeters using FT Raman spectroscopy Phys. Med. Biol. 46 1949-61
14. Jirasek A I, Duzenli C, Audet C and Eldridge J 2001 Characterization of monomer/crosslinker consumption and polymer formation observed in FT-Raman spectra of irradiated polyacrylamide gels Phys. Med. Biol. 46 151-65
15. Keller B 1994 Characterization of the NMR-based Fricke-gelatin radiation dosimeter MSc Thesis McGill University, Montreal, PQ
16. Kron T 2001 Radiation therapy requirements: what do we expect from gel dosimetry Proc. 2nd Int. Conf. on Radiotherapy Gel Dosimetry (Brisbane, Australia) pp 2-9
17. Lepage M, Jayasakera P M, Back S A J and Baldock C 2001a Dose resolution optimization of polymer gel dosimeters using different monomers Phys. Med. Biol. 46 2665-80
18. Lepage M, Whittaker A K, Rintoul L, Back S A J and Baldock C 2001b The relationship between radiation-induced chemical processes and transverse relaxation times in polymer gel dosimeters Phys. Med. Biol. 46 1061-74
19. Lepage M, Whittaker A K, Rintoul L, Back S A J and Baldock C 2001c Modelling of post-irradiation events in polymer gel dosimeters Phys. Med. Biol. 46 2827-39
20. 1H-NMR and FT-Raman study of radiation-induced modifications in radiation dosimetry polymer gels J. Appl. Polym. Sci. 79 1572-81
21. Lynch L J 1983 Water relaxation in heterogeneous and biological systems Magn. Reson. Imaging 2 248
22. Mansour F, Peemoeller H, Audet C and Schreiner L J 1997 Study of NMR time evolution parameters for polymer gel dosimetry Phys. Can. 53 110
23. Maryanski M J, Audet C and Gore J C 1997 Effects of crosslinking and temperature on the dose response of a BANG polymer gel dosimeter Phys. Med. Biol. 42 303-11
24. Maryanski M J, Gore J C, Kennsen R P and Schultz R J 1993 NMR relaxation enhancement in gels polymerized and crosslinked by ionizing radiation: a new approach to 3D dosimetry by MRI Magn. Reson. Imaging 11 253-8
25. Maryanski M J, Schulz R J, Ibbott G S, Gatenby J C, Xie J, Horton D and Gore J C 1994 Magnetic resonance imaging of radiation dose distributions using a polymer-gel dosimeter Phys. Med. Biol. 39 1437-55
26. McAuley K B 2004 Private communication
27. McJury M, Oldham M, Cosgrove V P, Murphy P S, Doran S, Leach M O and Webb S 2000 Radiation dosimetry using polymer gels: methods and applications Br. J. Radiol. 73 919-29
28. McJury M, Oldham M, Leach M O and Webb S 1999 Dynamics of polymerization in polyacrylamide gel (PAG) dosimeters: I. Ageing and long-term stability Phys. Med. Biol. 44 1863-73
29. Novotny J Jr, Spevacek V, Dvorak P, Novotny J and Cechak T 2001 Energy and dose rate dependence of BANG-2 polymer-gel dosimeter Med. Phys. 28 2379-86
30. Oldham M, Siewerdsen J H, Shetty A and Jaffray D A 2001 High resolution gel-dosimetry by optical-CT and MR scanning Med. Phys. 28 1436-45
31. Pearce E M, Wright C E and Bordoloi P 1982 Laboratory Experiments in Polymer Synthesis and Characterization (Pennsylvania State University, PA
32. Resing H A 1972 NMR relaxation of adsorbed molecules with emphasis on adsorbed water Adv. Mol. Relax. Process. 3 199-226
33. Salomons G J, Park Y S, McAuley K B and Schreiner L J 2002 Temperature increases associated with polymerization of irradiated PAG dosimeters Phys. Med. Biol. 47 1435-48
34. Schreiner L J, Cameron I G, Miljkovic L, Pintar M M, Funduk N and Kydon D W 1991a Proton NMR spin grouping and exchange in dentin Biophys. J. 59 629-39
35. Schreiner L J, MacTavish J C, Pintar M M and Rupprecht A 1991b NMR spin grouping and correlation exchange analysis: application to low hydration NaDNA paracrystals Biophys. J. 59 221-34
36. Sobol W T and Pintar M M 1987 NMR spectroscopy of heterogeneous solid-liquid mixtures: spin grouping and exchange analysis of proton spin relaxation of tissue Magn. Reson. Med. 4 537
37. Zhang D 1990 Characterization of proton spin relaxation in a polyacrylamide gel MSc Thesis University of Waterloo, ON
38. Zimmerman J R and Brittin W E 1957 Nuclear magnetic resonance studies in multiple phase systems: lifetime of a water molecule in an absorbing phase on silica gel J. Phys. Chem. 61 1328-33