Induction of CD8+ T cell responses through targeting of antigen to Dectin-2

Cellular Immunology

Volumn 239, Issue 2, 2006, Pages 87-91

  Carter, Robert W ^a   Thompson, Clare ^a   Reid, Delyth M ^a   Wong, Simon Y C ^a   Tough, David F ^a  

^a EDWARD JENNER INST FOR VACC RES   (United Kingdom)

Author keywords

C type lectin receptor; CD8+ T cells; Dectin 2; Dendritic cells; Vaccination

Indexed keywords

ANTIGEN; DECTIN 2; LECTIN RECEPTOR; MONOCLONAL ANTIBODY; OVALBUMIN; PROTEIN ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIGEN ANTIBODY REACTION; ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DENDRITIC CELL; IN VIVO STUDY; LYMPH NODE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN TARGETING;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGEN PRESENTATION; BINDING SITES, ANTIBODY; CD8-POSITIVE T-LYMPHOCYTES; CELL LINE; DRUG DELIVERY SYSTEMS; HYBRIDOMAS; INJECTIONS, SUBCUTANEOUS; LECTINS, C-TYPE; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC;

EID: 33745823102     PISSN: 00088749     EISSN: 10902163     Source Type: Journal    
DOI: 10.1016/j.cellimm.2006.05.001     Document Type: Article

References (21)

1. Carayanniotis G., and Barber B.H. Adjuvant-free IgG responses induced with antigen coupled to antibodies against class II MHC. Nature 327 (1987) 59-61
2. Finkelman F.D., Lees A., Birnbaum R., Gause W.C., and Morris S.C. Dendritic cells can present antigen in vivo in a tolerogenic or immnogenic fashion. J. Immunol. 157 (1996) 1406-1414
3. Boyle J.S., Brady J.L., and Lew A.M. Enhanced responses to a DNA vaccine encoding a fusion antigen that is directed to sites of immune induction. Nature 392 (1998) 408-411
4. Wang H., Griffiths M.N., Burton D.R., and Ghazal P. Rapid antibody responses by low-dose, single-step, dendritic cell-targeted immunization. Proc. Natl. Acad. Sci. USA 96 (2000) 847-852
5. Lunde E., Western K.H., Rasmussen I.B., Sandlie I., and Bogen B. Efficient delivery of T cell epitopes to APC by use of MHC class II-specific Troybodies. J. Immunol. 168 (2002) 2154-2162
6. Bonifaz L.C., Bonnyay D.P., Charalambous A., Darguste D.I., Fujii S.-I., Soares H., Brimnes M.K., Moltedo B., Moran T.M., and Steinman R.M. In vivo targeting of antigens to maturing dendritic cells via the DEC-205 receptor improves T cell vaccination. J. Exp. Med. 199 (2004) 815-824
7. - dendritic cell subset induces humoral immunity in the absence of conventional "danger". Eur. J. Immunol. 35 (2005) 2815-2825
8. fernandes M.J., Finnegan A.A., Siracusa L.D., Brenner C., Iscove N.N., and Calabretta B. Characterization of a novel receptor that maps near the natural killer gene complex: demonstration of carbohydrate binding and expression in hematopoietic cells. Cancer Res. 59 (1999) 2709-2717
9. Ariizumi K., Shen G.-L., Shikano S., Ritter R., Zukas P., Edelbaum D., Morita A., and Takashima A. Cloning of a second dendritic cell-associated C-type lectin (Dectin-2) and its alternatively spliced isoforms. J. Biol. Chem. 275 (2000) 11957-11963
10. Balch S.G., Greaves D.R., Gordon S., and McKnight A.J. Organization of the mouse macrophage C-type lectin (Mcl) gene and identification of a subgroup of related lectin molecules. Eur. J. Immunogenet. 29 (2002) 61-64
11. McGreal E.P., Rosas M., Brown G.D., Zamze S., Wong S.Y.C., Gordon S., Martinez-Pomares L., and Taylor P.R. The carbohydrate recognition domain of Dectin-2 is a C-type lectin with specificity for high-mannose. Glycobiology (2006) Epub ahead of print
12. Taylor P.R., Reid D.M., Heinsbroek S.E.M., Brown G.D., Gordon S., and Wong S.Y.C. Dectin-2 is predominantly myeloid restricted and exhibits unique activation-dependent expression on maturing inflammatory monocytes elicited in vivo. Eur. J. Immunol. 35 (2005) 2163-2174
13. Taylor P.R., Brown G.D., Reid D.M., Willment J.A., Martinez-Pomares L., Gordon S., and Wong S.Y.C. The beta-glucan receptor, Dectin-1, is predominantly expressed on the surface of cells of the monocyte/macrophage and neutrophil lineages. J. Immunol. 169 (2002) 3876-3882
14. Reid D.M., Montoya M., Taylor P.R., Borrow P., Gordon S., Brown G.D., and Wong S.Y.C. Expression of the β-glucan receptor, Dectin-1, on murine leukocytes in situ correlates with its function in pathogen recognition and reveals potential roles in leukocyte interactions. J. Leukoc. Biol. 76 (2004) 86-94
15. Linehan S.A., Martinez-Pomares L., Stahl P.D., and Gordon S. Mannose receptor and its putative ligands in normal murine lymphoid and non-lymphoid organs: In situ expression of mannose receptor by selected macrophages, endothelial cells, perivascular microglia, and mesangial cells, but not dendritic cells. J. Exp. Med. 189 (1999) 1961-1972
16. Henri S., Vremec D., Kamath A., Waithman J., Williams S., Benoist C., Burnham K., Saeland S., Handman E., and Shortman K. The dendritic populations of mouse lymph nodes. J. Immunol. 167 (2001) 741-748
17. + T cell responses through in vivo targeting of antigen to Dectin-1, J. Immunol. (2006), in press.
18. + dendritic cells abrogates priming of CD8 T cells by exogenous cell-associated antigens. Immunity 17 (2002) 211-220
19. Heath W.R., Belz G.T., Behrens G.M.N., Smith C.M., Forehan S.P., Parish I.A., Davey G.M., Wilson N.S., Carbone F.R., and Villadangos J.A. Cross-presentation, dendritic cell subsets, and the generation of immunity to cellular antigens. Immunol. Rev. 199 (2004) 9-26
20. Aragane Y., Maeda A., Schwarz A., Tezuka T., Ariizumi K., and Schwarz T. Involvement of dectin-2 in ultraviolet radiation-induced tolerance. J. Immunol. 171 (2003) 3801-3807
21. + regulatory T cells for immunologic self-tolerance and negative control of immune responses. Annu. Rev. Immunol. 22 (2004) 531-562