Extraction of 20(S)-ginsenoside Rg2 from cultured Panax notoginseng cells in vitro stimulates human umbilical cord vein endothelial cell proliferation

American Journal of Therapeutics

Volumn 13, Issue 3, 2006, Pages 205-210

  Xin, Xiujuan ^a   Liu, Jianwen ^a   Li, Xiqiang ^a   Zhong, Jianjiang ^a   Wei, Dongzhi ^a  

^a EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

20(S) ginsenoside Rg2; Human umbilical cord vein endothelial cell (VEC); Panax notoginseng; Plant cell culture; Plasminogen activator (PA) level

Indexed keywords

GINSENOSIDE RG 2; PLASMINOGEN ACTIVATOR;

ARTICLE; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG ISOLATION; DRUG PURIFICATION; DRUG STRUCTURE; ENDOTHELIUM CELL; GINSENG; HUMAN; HUMAN CELL; MEDICINAL PLANT; PANAX NOTOGINSENG; PLANT CELL CULTURE; PRIORITY JOURNAL; STATISTICAL ANALYSIS; UMBILICAL VEIN; VASCULAR ENDOTHELIUM;

CELL PROLIFERATION; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; GINSENOSIDES; HUMANS; PANAX; PLASMINOGEN ACTIVATORS; UMBILICAL CORD;

EID: 33745819587     PISSN: 10752765     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.mjt.0000212706.73410.57     Document Type: Article

References (19)

1. Tang W, Eisenbrand G, Mayer CA. Panax ginseng. In: Chinese Drugs of Plant Origin. Berlin: Springer; 1992:710-737.
2. Ma WG, Masanori M, Karl M. Saponins from the roots of Panax notoginseng. Phytochemistry. 1999;2:1133-1139.
3. Wang W, Zhong JJ. Manipulation of ginsenoside heterogeneity in cell cultures of Panax notoginseng by addition of Jasmonates. J Biosci Bioeng. 2002;93:48-53.
4. Proctor JTA. Ginseng: old crop, new directions. In: Janick J, ed. Progress in New Crops. Arlington, VA: ASHS Press; 1996:565-577.
5. Rainde F, Neil E, Flora S, et al. Towards molecular farming in the future: using plant cell suspension cultures: as bioreactors. Bioechnology. 1999;30:109-112.
6. - readily adds to the coordination N-heterocycles in the complexes. Hemost Thromb. 1989;9:87-115.
7. Miles LA, Dahlberg CM, Plescia J, et al. Role of cell-surface lysine in plasminogen binding to cells: identification of α-enolase as a candidate plasminogen receptor. Biochemistry. 1991;30:1682-1691.
8. Bendixen E, Berth W, Harpel PC. Transglutaminases catalyze cross-linking of plasminogen to fibronectin and human endothelial cells. J Biol Chem. 1993;268:21962-21967.
9. Mignatti P, Rifkin DB. Biology and biochemistry of proteinase in tumor invasion. Physiol Rev. 1993;73:161-195.
10. Wilhem He C, Pentland SM, Marmer AP, et al. Tissue cooperation in a proteolytic cascade activating human interstitial collagenase. Proc Natl Acad Sci USA. 1989;86:2632-2636.
11. Flaumenhaft R, Kojima S, Rifkin DB. Activation of latent transforming growth factor β. Adv Pharmacol. 1993;24:51-76.
12. Odashima S, Ohta T, Kohno H, et al. Control of phenotypic expression of cultured B16 melanoma cells by plant glycosides. Cancer Res. 1985;45:2781-2784.
13. Sato K, Mochizuki M, Samukawa K, et al. Inhibition of tumor angiogenesis and metastasis by a saponin of Panax ginseng, ginsenoside-Rb2. Bio Pharm Bull. 1994;17:635-639.
14. Zhong LG, Zheng GZ, Gan FY, et al. Separation and identification of main medicinal saponin components from mass cell cultures of Panax notoginseng (Burk). Acta Pharmacol Sin. 1991;26:876-880.
15. 2 Chem. Pharm Bull. 1974;22:2407-2412.
16. Cord S, Laplace C, Vicaut E, et al. Rapid reactive oxygen species production by mitochondria in endothelial cells exposed to tumor necrosis factor-α is mediated by ceramide. Am J Respir Cell Mol Biol. 2001;24:762-768.
17. Choy JC, Granville DJ, Hunt DW. Endothelial cell apoptosis: biochemical characteristics and potential implications for atherosclerosis. J Mol Cell Cardiol. 2001;33:1673-1690.
18. Dimmeler S, Hermann C, Zeiher AM. Apoptosis of endothelial cells. Contribution to the pathophysiology of atherosclerosis? Eur Cytokine Netw. 1998;9:697-708.
19. Berislav V, Zlokovic MD. Antithrombotic, procoagulant, and fibrinolytic mechanisms in cerebral circulation: implications for brain injury and protection. Neurosurg Focus. 2003;2:654-685.