Generation of the BCR/ABL fusion gene in a Philadelphia chromosome-negative chronic myeloid leukaemia: Insertion of 5.6 Mb of 9q34 into the BCR region of chromosome 22

Hematological Oncology

Volumn 24, Issue 2, 2006, Pages 86-88

  Valle, Laura ^a   Fernández, Victoria ^a   Pérez Pons, Concepción ^b   Sánchez, Félix García ^c   Benítez, Javier ^a   Urioste, Miguel ^a  

^a Centro Nacional de Investigaciones Oncológicas   (Spain)

^b HOSPITAL SEVERO OCHOA   (Spain)

^c Centro de Transfusion de Madrid   (Spain)

Author keywords

BCR ABL; Chronic Myeloid Leukaemia; CML; Masked Ph

Indexed keywords

IMATINIB;

ABL GENE; AGED; ANAMNESIS; ARTICLE; BCR GENE; CASE REPORT; CHROMOSOME 22; CHROMOSOME 9; CHROMOSOME ANALYSIS; CLINICAL FEATURE; FUSION GENE; GENE EXPRESSION; HUMAN; KARYOTYPE; MALE; MYELOID LEUKEMIA; PHILADELPHIA CHROMOSOME NEGATIVE CELL; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

AGED; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 22; FUSION PROTEINS, BCR-ABL; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; LEUKEMIA, MYELOID, CHRONIC; MALE;

EID: 33745792331     PISSN: 02780232     EISSN: 10991069     Source Type: Journal    
DOI: 10.1002/hon.775     Document Type: Article

References (10)

1. Kurzrock R, Gutterman JU, Talpaz M. The molecular genetics of Philadelphia chromosome-positive leukemias. N Engl J Med 1988; 319: 990-998.
2. Reddy KS, Sulcova V. A FISH study of variant Philadelphia rearrangements. Cancer Genet Cytogenet 2000; 118: 121-131.
3. van der Plas DC, Grosveld G, Hagemeijer A. Review of clinical, cytogenetic, and molecular aspects of Ph-negative CML. Cancer Genet Cytogenet 1991; 52: 143-156.
4. Zagaria A, Anelli L, Albano F, et al. A fluorescence in situ hybridization study of complex t(9;22) in two chronic myelocytic leukemia cases with a masked Philadelphia chromosome. Cancer Genet Cytogenet 2004; 150: 81-85.
5. Morel F, Herry A, Le Bris MJ, et al. Contribution of fluorescence in situ hybridization analyses to the characterization of masked and complex Philadelphia chromosome translocations in chronic myelocytic leukemia. Cancer Genet Cytogenet 2003; 147: 115-120.
6. Cross NC, Melo JV, Feng L, Goldman JM. An optimized multiplex polymerase chain reaction (PCR) for detection of BCR-ABL fusion mRNAs in haematological disorders. Leukemia 1994; 8: 186-189.
7. Uphoff CC, Habig S, Fombonne S, Matsuo Y, Drexler HG. ABL-BCR expression in BCR-ABL-positive human leukemia cell lines. Leuk Res 1999; 23: 1055-1060.
8. Morris CM, Heisterkamp N, Kennedy MA, Fitzgerald PH, Groffen J. Ph-negative chronic myeloid leukemia: molecular analysis of ABL insertion into M-BCR on chromosome 22. Blood 1990; 76: 1812-1818.
9. Monma F, Nishii K, Yamamori S, et al. Fluorescent in situ hybridization analysis of Philadelphia chromosome-negative chronic myeloid leukemia with the bcr/abl fusion gene. Int J Hematol 2004; 80: 155-158.
10. Saglio G, Storlazzi CT, Giugliano E, et al. A 76-kb duplicon maps close to the BCR gene on chromosome 22 and the ABL gene on chromosome 9: possible involvement in the genesis of the Philadelphia chromosome translocation. Proc Natl Acad Sci USA 2002; 99: 9882-9887.