Sequence analysis and functional study of thymidylate synthase from zebrafish, Danio rerio

Journal of Biochemistry

Volumn 139, Issue 5, 2006, Pages 913-920

  Du, Changqing ^a,b   Niu, Rongli ^a   Chu, Edward ^c   Zhang, Peijun ^a   Lin, Xiukun ^a  

^a INSTITUTE OF OCEANOLOGY   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^c YALE CANCER CENTER   (United States)

Author keywords

Cloning and expression; Development of zebrafish embryos; Enzymatic activity; Thymidylate synthase; Zebrafish

Indexed keywords

AMINO ACID DERIVATIVE; COMPLEMENTARY DNA; NUCLEOTIDE DERIVATIVE; SHORT HAIRPIN RNA; THYMIDYLATE SYNTHASE;

AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; DNA ISOLATION; EMBRYO; EMBRYO DEVELOPMENT; ENZYME ACTIVITY; ENZYME KINETICS; ESCHERICHIA COLI; GENE SEQUENCE; GENE SILENCING; NONHUMAN; OPEN READING FRAME; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PURIFICATION; PROTEIN TARGETING; RNA INTERFERENCE; SEQUENCE ANALYSIS; WESTERN BLOTTING; ZEBRA FISH;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CLONING, MOLECULAR; DNA, COMPLEMENTARY; ESCHERICHIA COLI; GENE SILENCING; HUMANS; MICE; PHYLOGENY; RATS; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS; THYMIDYLATE SYNTHASE; ZEBRAFISH; ZEBRAFISH PROTEINS;

ANIMALIA; DANIO RERIO; ESCHERICHIA COLI;

EID: 33745762405     PISSN: 0021924X     EISSN: None     Source Type: Journal    
DOI: 10.1093/jb/mvj100     Document Type: Article

References (42)

1. Carreras, C. and Santi, D.V. (1995) The catalytic mechanism and structure of thymidylate synthase. Annu. Rev. Biochem. 64, 721-762
2. Montfort, W.R., Perry, K.M., Fauman, E.B., Finer-Moore, J.S., Maley, G.F., Hardy, L., Maley, F., and Stroud, R.M. (1990) Structure, multiple site binding, and segmental accommodation in thymidylate synthase on binding dUMP and an anti-folate. Biochemisty 29, 6964-6977
3. Matthews, D.A., Appelt, K., Oatley, S.J., and Xuong, N.H. (1990) Crystal structure of Escherichia coli thymidylate synthase containing bound 5-fluoro-2′-deoxyuridylate and 10-propargyl-5,8-dideazafolate. J. Mol. Biol. 214, 923-936
4. Danenberg, P.V. (1977) Thymidylate synthetase-a target enzyme in cancer chemotherapy. Biochim. Biophys. Acta 473, 73-92
5. Schmitz, J.C., Liu, J., Lin, X., Chen, T.M., Yan, W., Tai, N., and Chu, E. (2001) Translational regulation as a novel mechanism for the development of cellular drug resistance. Cancer Metastasis Rev. 20, 33-41
6. Goldsmith, P. (2004) Zebrafish as a pharmacological tool: the how, why and when. Curr. Opin. Pharm. 4, 504-512
7. Dooley, K. and Zon, L.I. (2000) Zebrafish: a model system for the study of human disease. Curr. Opin. Gen. Dev. 10, 52-256
8. Langheinrich, U. (2003) Zebrafish: a new model on the pharmaceutical catwalk. Bioassay 25, 904-912
9. Postlethwait, J.H., Woods, I.G., Ngo-Hazelett, P., Yan, Y.L., Kelly, P.D., Chu, F., Huang, H., Hill-Force, A., and Talbot, W.S. (2000) Zebrafish comparative genomics and the origins of vertebrate chromosomes. Genome Res. 10, 1890-1902
10. Liu, T.X., Zhou, Y., Kanki, J.P., Deng, M., Rhodes, J., Yang, H.W., Sheng, X.M., Zon, L.I., and Look, A.T. (2002) Evolutionary conservation of zebrafish linkage group 14 with frequently deleted regions of human chromosome 5 in myeloid malignancies. Proc. Natl. Acad. Sci. USA 99, 6136-6776
11. Montfort, W.R. and Weichsel A. (1997) Thymidylate synthase: structure, inhibition, and strained conformations during catalysis. Pharmacol. Ther. 76, 29-43
12. Finer-Moore, J.S., Santi, D.V., and Stroud, R.M. (2003) Lessons and conclusions from dissecting the mechanism of a bisubstrate enzyme: thymidylate synthase mutagenesis, function, and structure. Biochemistry 42, 248-256
13. Schmitz, J.C., Gollerkeri, A., Lin, X., Liu, J., and Chu, E. (2002) Fluoropyrimidines in Cancer Therapy (Rustum, Y.M., ed.) pp. 67-82, Human Press, NJ
14. Liu, J., Schmitz, J.C., Lin, X., Tai, N., Yan, W., Farrell, M., Bailly, M., Chen, T., and Chu, E. (2002). Thymidylate synthase as a translational regulator of cellular gene expression. Biochim Biophys. Acta 1587, 174-182
15. Dodd, A., Chambers, S.P., and Love, D.R. (2004) Short interfering RNA-mediated gene targeting in the zebrafish. FEBS Lett. 561, 89-93
16. Liu, W.Y., Wang, Y., Sun, Y.H., Wang, Y., Wang, Y.P., Chen, S.P., and Zhu, Z.Y. (2005) Efficient RNA interference in zebrafish embryos using siRNA synthesized with SP6 RNA polymerase. Dev. Growth Differ. 47, 323-331
17. Kimmel, C.B., Ballard, W.W., Kimme, S.R., Ullmann, I.B., and Schilling, T.F. (1995) Stages of embryonic development of the zebrafish. Dev. Dyn. 203, 253-310
18. Lin, X., Liu, J., Maley, F., and Chu, E. (2003) Role of cysteine amino acid residues on the RNA binding activity of human thymidylate synthase. Nucleic Acids Res. 31, 4882-1887
19. Laemmli U.K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-685
20. Hong, J.R., Lin, T.L., Hsu, Y.L. and Wu, J.L. (1998) Apoptosis proceeds necrosis of fish cell line by infectious pancreatic necrosis virus. J. Virol. 73, 5056-5063
21. Takeishi, K., Kaneda, S., Ayusawa, D., Shimizu, K., Gotoh, O., and Seno, T. (1985) Nucleotide sequence of a functional cDNA for human thymidylate synthase. Nucleic Acids Res. 25, 2035-2043
22. Perryman, S.M., Rossana, C., Deng, T., Vanin, E.F., and Johnson, L.F. (1986) Sequence of a cDNA for mouse thymidylate synthase reveals striking similarity with the prokaryotic enzyme. Mol. Biol. Evol. 3, 313-321
23. Deng, T., Li, D., Jenh, C.-H., and Johnson, L.F. (1986) Structure of the gene for mouse thymidylate synthase. Locations of introns and multiple transcriptional start sites. J. Biol. Chem. 261, 16000-16005
24. Ciesla, J., Weiner, K.X., Weiner, R.S., Reston, J.T., Maley, G.F., and Maley, F. (1995) Isolation and expression of rat thymidylate synthase cDNA: phylogenetic comparison with human and mouse thymidylate syntheses. Biochim. Biophys. Acta 1261, 233-242
25. Belfort, M., Maley, G.F., Pedersen-Lane, J., and Maley, F. (1983) Primary structure of the Escherichia coli thyA gene and its thymidylate synthase product. Proc. Natl. Acad. Sci. USA 80, 4914-1918
26. Purohit, S. and Mathews, C.K. (1984) Nucleotide sequence reveals overlap between T4 phage genes encoding dihydrofolate reductase and thymidylate synthase. J. Biol. Chem. 265, 8317-8321
27. Beverley, S., Ellenberger, T., and Cordingley, J. (1986) Primary structure of the gene encoding the bifunctional dihydrofolate reductase-thymidylate synthase of Leishmania major. Proc. Natl. Acad. Sci. USA 83, 2584-2588
28. Schiffer, C.A., Clifton, I.J., Davisson, V.J., and Santi, D.V. (1995) Crystal structure of human thymidylate synthase: a structural mechanism for guiding substrates into the active site. Biochemistry 34, 16279-16287
29. Mandola, M.V., Stoehlmacher, J., Muller-Weeks, S., Cesarone, G., Yu, M.C., Lenz, H.J., and Ladner, R.D. (2003) A novel single nucleotide polymorphism within the 5′ tandem repeat polymorphism of the thymidylate synthase gene abolishes USF-1 binding and alters transcriptional activity. Cancer Res. 63, 2898-2904
30. Kawakami, K., Salonga, D., Park, J.M., Danenberg, K.D., Uetake, H., Brabender, J., Omura, K., Watanabe, G., and Danenberg, P.V. (2001) Different lengths of a polymorphic repeat sequence in the thymidylate synthase gene affect translational efficiency but not its gene expression. Clin. Caner Res. 7, 4091-5101
31. Lecomte, T., Ferraz, J.M., Zinzindohoue, F., Loriot, M.A., Tregouet, D.A., Landi, B., Berger, A., Cugnenc, P.H., Jian, R., Beaune, P., and Laurent-Puig, P. (2004) Thymidylate synthase gene polymorphism predicts toxicity in colorectal cancer patients receiving 5-fluorouracil-based chemotherapy. Clin. Cancer Res. 10, 5880-5888
32. Lin, X., Parsels, L.A., Voeller, D.M., Allegra, C.J., Maley, G.F., Maley, F., and Chu, E. (2000) Characterization of a cis-acting regulatory element in the protein coding region of thymidylate synthase mRNA. Nucleic Acids Res. 28, 1381-1389
33. Westerfield, M. (2000) The Zebrafish Book, University of Oregon Press, Eugene, OR
34. Sugahara, T., Liu, C.C., Carter, G., Pai, T.G., and Liu, M.C. (2003) cDNA cloning, expression, and functional characterization of a zebrafish SULT1 cytosolic sulfotransferase. Arch. Biochem. Biophys. 414, 67-73
35. Sugahara, T., Yang, YS., Liu, C.C., Pai, G., and Liu, M.C. (2003) Sulphonation of dehydroepiandrosterone and neurosteroids: molecular cloning, expression, and functional characterization of a novel zebrafish SULT2 cytosolic sulphotransferase. Biochem. J. 375, 785-791
36. Ju, J., Kane, S.E., Lenz, H.J., Danenberg, K.D., Chu, E., and Danenberg, P.V. (1998) Desensitization and sensitization of cells to fluoropyrimidines with different antisenses directed against thymidylate synthase messenger RNA. Clin. Cancer Res. 4, 2229-2236
37. Dabrowska, M., Jagielska, E., Ciesla, J., Plucienniczak, A., Kwiatowski, J., Wranicz, M., Boireau, P., and Rode, W. (2004) Trichinella spiralis thymidylate synthase: cDNA cloning and sequencing, and developmental pattern of mRNA expression. Parasitology 128, 209-221
38. Cox, K., Robertson, D., and Fites, R. (1999) Mapping and expression of a bifunctional thymidylate synthase, dihydrofolate reductase gene from maize. Plant Mol. Biol. 41, 733-739
39. Ju, J., Pedersen-Lane, J., Maley, F., and Chu, E. (1999) Regulation of p53 expression by thymidylate synthase. Proc. Natl. Acad. Sci. USA 96, 3769-3774
40. Schmitz, J.C., Chen, T.M., and Chu, E. (2004) Small interfering double-stranded RNAs as therapeutic molecules to restore chemosensitivity to thymidylate synthase inhibitor compounds. Cancer Res. 64, 1431-1435
41. Parng, C., Seng, W.L., Semino, C., McGrath, P. (2002) Zebrafish: A preclinical model for drug screening. Assay Drug Dev. Technol. 1, 41-48
42. Chu, E., Callender M.A., and Farrell M.P. (2003) Thymidylate synthase inhibitors as anticancer agents: from bench to besides. Cancer Chemother. Pharmcol. 52, S80-S89