Immobilization of cholesterol esterase for use in multiple batch biotransformations to prepare (-)- FTC (emtricitabine)

Organic Process Research and Development

Volumn 10, Issue 3, 2006, Pages 670-672

  Osborne, Andrew P ^a,b   Brick, Dean ^a,c   Ruecroft, Graham ^a,d   Taylor, Ian N ^a  

^a DOW CHEMICAL COMPANY   (United States)

^b EKB Technology Ltd   (United Kingdom)

^c PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

^d C3 Technology   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 33745761261     PISSN: 10836160     EISSN: None     Source Type: Journal    
DOI: 10.1021/op050258f     Document Type: Article

References (8)

1. (a) Liotta, D. C.; Choi, W.-B. PCT Int. Appl. WO 91252418, 1991.
2. (b) Liotta, D. C.; Schinazi, R. F.; Choi, W.-B. PCT Int. Appl. WO 9214743, 1992.
3. (c) Painter, G. R.; Liotta, D. C.; Almond, M.; Cleary, D.; Soria, J. PCT Int. Appl. WO 2000009494, 2000.
4. Hoong, L. K.; Strange, L. E.; Liotta, D. C.; Koszalka, G. W.; Burns, C. L.; Schinazi, R. F. J. Org. Chem. 1992, 57, 5563-5565.
5. Gaede, B. J.; Nardelli, C. A. Org. Process Res. Dev. 2005, 9(1), 23.
6. Cholesterol esterase from Candida cyclindracea was purchased from Boehringer Mannheim.
7. Gitlesen, T.; Bauer, M.; Adlercreutz, P. Biochim Biophys Acta 1997, 1345(2), April 1, 188.
8. Chen, C. C.; Fujimoto, Y.; Girdaukas, G.; Sih, C. J. J. Am. Chem. Soc. 1982, 104, 7294-99.