Synthesis and biological evaluation of 1β-methylcarbapenems having cyclic thiourea moieties and their related compounds

European Journal of Medicinal Chemistry

Volumn 41, Issue 7, 2006, Pages 825-832

  Han, T ^b   Cho, J H ^a   Oh, C H ^a  

^a Korea Institute of Science and Technology   (South Korea)

^b Hawon Pharm Co   (South Korea)

Author keywords

1 Methylcarbapenems; Antibacterial activity; Substituent effects

Indexed keywords

1BETA METHYLCARBAPENEM DERIVATIVE; 6 [HYDROXYETHYL] 2 [5 [5 (THIOMORPHOLINYLTHIOUREIDO)METHYL]PYRROLIDIN 3 YLTHIO] 1 METHYLCARBAPEN 2 EM 3 CARBOXYLIC ACID; ANTIINFECTIVE AGENT; IMIPENEM; MEROPENEM; PYRROLIDINE DERIVATIVE; THIOUREA DERIVATIVE; UNCLASSIFIED DRUG; 1 BETA METHYLCARBAPENEM; 1 BETA-METHYLCARBAPENEM; CARBAPENEM DERIVATIVE; THIOUREA;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL STRAIN; BIOLOGICAL ACTIVITY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENCY; DRUG SYNTHESIS; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; NONHUMAN; CHEMICAL STRUCTURE; CHEMISTRY; CYCLIZATION; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANTI-BACTERIAL AGENTS; CARBAPENEMS; CYCLIZATION; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; THIOUREA;

EID: 33745759901     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2006.02.006     Document Type: Article

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