Isolation and insecticidal/anthelmintic activity of xanthonol, a novel bis-xanthone, from a non-sporulating fungal species

Journal of Antibiotics

Volumn 59, Issue 5, 2006, Pages 288-292

  Ondeyka, John G ^a   Dombrowski, Anne W ^a   Polishook, Jon P ^a   Felcetto, Tom ^a   Shoop, Wesley L ^a   Guan, Ziqiang ^a   Singh, Sheo B ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Anthelmintic; Insecticide; Non sporulating fungus; Xanthonol

Indexed keywords

ANTHELMINTIC AGENT; INSECTICIDE; IVERMECTIN; PARAHERQUAMIDE; SEPHADEX; UNCLASSIFIED DRUG; XANTHONE DERIVATIVE; XANTHONOL;

AEDES AEGYPTI; ANTHELMINTIC ACTIVITY; ARTICLE; DRUG HYDROLYSIS; DRUG ISOLATION; DRUG STRUCTURE; FERMENTATION; FLY; FUNGUS; HAEMONCHUS CONTORTUS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INSECTICIDAL ACTIVITY; LARVA; LUCILIA SERICATA; PRIORITY JOURNAL; SPECTROSCOPY;

ANTHELMINTICS; FUNGI; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; INSECTICIDES; MOLECULAR STRUCTURE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; OPTICAL ROTATION; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; XANTHONES;

AEDES AEGYPTI; HAEMONCHUS CONTORTUS; LUCILIA SERICATA;

EID: 33745753798     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.1038/ja.2006.40     Document Type: Article

References (11)

1. Ondeyka JG, Dombrowski AW, Polishook JP, Felcett T, Shoop WL, Guan Z, Singh SB. Isolation and insecticidal activity of mellamide from Aspergillus melleus. J Ind Microbiol Biotechnol 30: 220-224 (2003)
2. Chabala JC, Mrozik H, Tolman RL, Eskola P, Lus A, Peterson LH, Woods MF, Fisher MH, Campbell WC, Ergerton JR, Ostlind D. Ivermectin, a new broad-spectrum antiparasitic agent. J Med Chem 23: 1134-1136 (1980)
3. Ondeyka JG, Goegelman R, Schaeffer JM, Keleman L, Zitano L. Novel antinematodal and antiparasitic agents from Penicillium charlesii. I Fermentation, isolation and biological activity. J Antibiot 43: 1375-1380 (1990)
4. Ondeyka JG, Helm GL, Hensens OD, Goetz MA, Zink DL, Tsipouras A, Shoop WL, Slayton L, Dombrowski AW, Polishook JD, Ostlind DA, Tsou NN, Ball RG, Singh SB. Nodulisporic acid A, a novel and potent insecticide from a Nodulisporium sp. Isolation, structure determination, and chemical transformations. J Am Chem Soc 119: 8809-8816 (1997)
5. Ostlind DA, Felcetto T, Misura A, Ondeyka JG, Smith S, Goetz M, Shoop W, Mickle W. Discovery of a novel indole diterpene insecticide using first instars of Lucilia sericata. Med Vet Entomol 11: 407-408 (1997)
6. Henrick CA, Staal CB, Siddall JB. Alkyl 3,7,11-trimethyl-2,4- dodecadienoates, a new class of potent insect growth regulations with juvenile hormone activity. J Agric Food Chem. 213: 354-359 (1973)
7. Michael B, Meinke PT, Shoop W. Comparison of ivermectin, doramectin, selamectin and eleven intermediates in a nematode larval development assay. J Parasitol 87: 692-696 (2001)
8. Wagenaar MW, Clardy J. Dicerandrols, new antibiotic and cytotoxic dimers produced by the fungus Phomopsis longicolla isolated from an endangered mint. J Nat Prod 64: 1006-1009 (2001)
9. Proksa B, Uhrin D, Liptaj T, Sturdikova M. Neosartorin, an ergochrome biosynthesized by Neosartorya fischeri. Phytochemistry 48: 1161-1164 (1998)
10. Nielsen RI, Rasmussen FW. (Novo Nordisk A/S). Fungicidally active compounds. U.S. 5,409, 95, April 25 (1995)
11. Franck B, Gottschalk EM, Ohnsorge U, Huper F. Chem Ber 99: 3842-3862 (1966)