One novel quinoxaline derivative as a potent human cyclophilin A inhibitor shows highly inhibitory activity against mouse spleen cell proliferation

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 16, 2006, Pages 5527-5534

  Li, Jian ^a   Chen, Jing ^a   Zhang, Li ^a,c   Wang, Feng ^a   Gui, Chunshan ^a   Qin, Yu ^c   Xu, Qiang ^c   Liu, Hong ^a   Nan, Fajun ^a   Shen, Jingkang ^a   Bai, Donglu ^a   Chen, Kaixian ^a   Shen, Xu ^a,b   Jiang, Hualiang ^a,b  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^c NANJING UNIVERSITY   (China)

Author keywords

Cyclophilin A; Fluorescence titration; Inhibitor; Quinoxaline; Surface plasmon resonance

Indexed keywords

2,3 BIS(FURAN 2 YL) 6 (3 N,N DIETHYLCARBAMOYLPIPERIDINO) CARBONYLAMINOQUINOXALINE; CONCANAVALIN A; CYCLOPHILIN; CYCLOPHILIN A; DC 838; IMMUNOSUPPRESSIVE AGENT; PROTEIN INHIBITOR; QUINOXALINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG BINDING; ENZYME ACTIVITY; FEMALE; FLUORESCENCE; IN VIVO STUDY; KINETICS; MOUSE; NONHUMAN; SPLEEN CELL; SURFACE PLASMON RESONANCE; TITRIMETRY;

ANIMALS; BINDING SITES; CELL PROLIFERATION; CYCLOPHILIN A; ENZYME INHIBITORS; HUMANS; KINETICS; MICE; MICE, INBRED ICR; QUINOXALINES; SPLEEN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33745748168     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.04.026     Document Type: Article

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