Safe and practical large-scale synthesis of 2-aminoquinoline-6-carboxylic acid benzyl ester

Organic Process Research and Development

Volumn 10, Issue 3, 2006, Pages 534-538

  Couturier, Michel ^a   Le, Tung ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 33745747321     PISSN: 10836160     EISSN: None     Source Type: Journal    
DOI: 10.1021/op060044d     Document Type: Article

References (12)

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5. (d) Sharma, K. S.; Kumari, S.; Singh, R. P. Synthesis 1981, 316.
6. (e) van Galen, P. J. M.; Nissen, P.; van Wijngaarden, I.; Ijzerman, A. P.; Soudijn, W. J. Med. Chem. 1991, 34, 1202.
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11. Kaczmarerek, L.; Balicki, R.; Nantka-Namirski, P. Chem. Ber. 1992, 125, 1965.
12. It is noteworthy that the nature of the suspension is ammonium chloride and not triethylammonium chloride prior to the addition of the activated N-oxide solution.