Long-term clearance from small airways in subjects with ciliary dysfunction

Respiratory Research

Volumn 7, Issue , 2006, Pages

  Lindström, Maria ^a,b   Falk, Rolf ^c   Hjelte, Lena ^b   Philipson, Klas ^a   Svartengren, Magnus ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c Swedish Radiation Protection Authority   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

INDIUM 111; POLITEF; INDIUM;

ADOLESCENT; ADULT; ARTICLE; CILIARY DYSKINESIA; CLINICAL ARTICLE; CONFIDENCE INTERVAL; CONTROLLED STUDY; FEMALE; HUMAN; INHALATION TEST; LUNG CLEARANCE; LUNG DEPOSIT; LUNG DIFFUSION; MALE; MUCOCILIARY CLEARANCE; MUCOCILIARY TRANSPORT; PARTICLE SIZE; RESPIRATORY AIRFLOW; STATISTICAL SIGNIFICANCE; TRACHEOBRONCHIAL TREE; BRONCHUS; COMPARATIVE STUDY; KARTAGENER SYNDROME; LUNG ALVEOLUS; LUNG FUNCTION TEST; PATHOPHYSIOLOGY; TIME;

ADOLESCENT; ADULT; BRONCHI; FEMALE; HUMANS; INDIUM RADIOISOTOPES; KARTAGENER SYNDROME; MALE; MUCOCILIARY CLEARANCE; PARTICLE SIZE; POLYTETRAFLUOROETHYLENE; PULMONARY ALVEOLI; RESPIRATORY FUNCTION TESTS; TIME FACTORS;

EID: 33745727099     PISSN: 1465993X     EISSN: 1465993X     Source Type: Journal    
DOI: 10.1186/1465-9921-7-79     Document Type: Article

References (44)

1. Camner P, Philipson K: Human alveolar deposition of 4 micron teflon particles. Arch Environ Health 1978, 33:181-185.
2. Smaldone G, Perry R, Bennett W, Messina M, Zwang J, Ilowite J: Interpretation of "24 hour retention" in studies of mucociliary clearance. J Aerosol Med 1988, 1:11-20.
3. Stahlhofen W, Scheuch G, Bailey M: Measurement of the tracheobronchial clearance of particles after aerosol bolus inhalation. Ann Occup Hyg 1994:189-196.
4. Falk R, Philipson K, Svartengren M, Bergmann R, Hofmann W, Jarvis N, Bailey M, Camner P: Assessment of long-term bronchiolar clearance of particles from measurements of lung retention and theoretical estimates of regional deposition. Exp Lung Res 1999, 25:495-516.
5. Svartengren M, Sommerer K, Scheuch G, Kohlhaeufl M, Heyder J, Falk R, Bergmann R, Hofmann W, Bailey M, Philipson K, Camner P: Comparison of clearance of particles inhaled with bolus and extremely slow inhalation techniques. Exp Lung Res 2001, 27:367-386.
6. Task Group on Lung Dynamics: Deposition and retention models for internal dosimetry of human respiratory tract. Health Phys 1966, 12:173-207.
7. Camner P, Mossberg B, Afzelius BA: Evidence of congenitally nonfunctioning cilia in the tracheobronchial tract in two subjects. Am Rev Respir Dis 1975, 112:807-809.
8. Afzelius BA, Camner P, Eliasson R, Mossberg B: Kartagener's syndrome does exist. Lancet 1978, 2:950.
9. Khan TZ, Wagener JS, Bost T, Martinez J, Accurso FJ, Riches DW: Early pulmonary inflammation in infants with cystic fibrosis. Am J Respir Crit Care Med 1995, 151:1075-1082.
10. Jeffery PK: Remodeling and inflammation of bronchi in asthma and chronic obstructive pulmonary disease. Proc Am Thorac Soc 2004, 1:176-183.
11. Svartengren K, Philipson K, Svartengren M, Nerbrink O, Camner P: Clearance in smaller airways of inhaled 6-microm particles in subjects with immotile-cilia syndrome. Exp Lung Res 1995, 21:667-682.
12. Svartengren K, Ericsson CH, Svartengren M, Mossberg B, Philipson K, Camner P: Deposition and clearance in large and small airways in chronic bronchitis. Exp Lung Res 1996, 22:555-576.
13. Lindstrom M, Camner P, Falk R, Hjelte L, Philipson K, Svartengren M: Long-term clearance from small airways in patients with cystic fibrosis. Eur Respir J 2005, 25:317-323.
14. Weibel ER: Morphometry of the human lung. New York: Springer Verlag, Berlin Academic Press; 1963:136-143.
15. Svartengren M, Falk R, Philipson K: Long-term clearance from small airways decreases with age. Eur Respir J 2005, 26:609-615.
16. Carson JL, Collier AM: Ciliary defects: cell biology and clinical perspectives. Adv Pediatr 1988, 35:139-165.
17. Ruusa J, Svartengren M, Philipson K, Camner P: Trancheobronchial deposition and clearance in immotile cilia syndrome patients. J Aerosol Med 1993, 6:89-98.
18. Falk R, Philipson K, Svartengren M: Clearance of particles from small ciliated airways. Exp Lung Res 1997, 23(6):495-515.
19. Anderson M, Philipson K, Svartengren M, Camner P: Human deposition and clearance of 6-micron particles inhaled with an extremely low flow rate. Exp Lung Res 1995, 21(1):187-195.
20. Quanjer PH, Tammeling GJ, Cotes JE, Pedersen OF, Peslin R, Yernault JC: Lung volumes and forced ventilatory flows. Report Working Party Standardization of Lung Function Tests, European Community for Steel and Coal. Official Statement of the European Respiratory Society. Eur Respir J Suppl 1993, 16:5-40.
21. Philipson K: Monodisperse labelled aerosols for studies of lung clearance. In Abstracts of Uppsala Volume 433. Dissertations from the Faculty of Science. Uppsala University. Uppsala, Sweden; 1977:1-36.
22. Camner P: The production and use of test aerosols for studies of human tracheobronchial clearance. Environ Physiol Biochem 1971, 1:37-154.
23. Stahlhofen W, Gebhart J, Heyder J, Philipson K, Camner P: Inter-comparison of regional deposition of aerosol particles in the human respiratory tract and their long-term elimination. Exp Lung Res 1981, 2(2):131-139.
24. Svartengren M, Svartengren K, Aghaie F, Philipson K, Camner P: Lung deposition and extremely slow inhalations of particles. Limited effect of induced airway obstruction. Exp Lung Res 1999, 25(4):353-366.
25. 195 Au-labelled teflon particles in humans. Exp Lung Res 1996, 22(1):65-83.
26. Moller W, Haussinger K, Winkler-Heil R, Stahlhofen W, Meyer T, Hofmann W, Heyder J: Mucociliary and long-term particle clearance in the airways of healthy nonsmoker subjects. J Appl Physiol 2004, 97(6):2200-2206.
27. Moller W, Haussinger K, Ziegler-Heitbrock L, Heyder J: Mucociliary and long-term particle clearance in airways of patients with immotile cilia. Respiratory Research 2006, 7:10.
28. Regnis JA, Zeman KL, Noone PG, Knowles MR, Bennett WD: Prolonged airway retention of insoluble particles in cystic fibrosis versus primary ciliary dyskinesia. Exp Lung Res 2000, 26(3):149-162.
29. Leith DE: Cough. Phys Ther 1968, 48(5):439-447.
30. Bennett WD, Chapman WF, Gerrity TR: Ineffectiveness of cough for enhancing mucus clearance in asymptomatic smokers. Chest 1992, 102(2):412-416.
31. Ellerman A, Bisgaard H: Longitudinal study of lung function in a cohort of primary ciliary dyskinesia. Eur Respir J 1997, 10(10):2376-2379.
32. Bush A, Payne D, Pike S, Jenkins G, Henke MO, Rubin BK: Mucus properties in children with primary ciliary dyskinesia: comparison with cystic fibrosis. Chest 2006, 129(1):118-123.
33. Svartengren M, Svartengren K, Europe E, Falk R, Hofmann W, Sturm R, Philipson K, Camner P: Long-term clearance from small airways in patients with chronic bronchitis: experimental and theoretical data. Exp Lung Res 2004, 30(5):333-353.
34. Noone PG, Leigh MW, Sannuti A, Minnix SL, Carson JL, Hazucha M, Zariwala MA, Knowles MR: Primary ciliary dyskinesia: Diagnostic and phenotypic features. Am J Respir Crit Care Med 2004, 169:459-467.
35. Mortensen J, Groth S, Lange P, Hermansen F: Effect of terbutaline on mucociliary clearance in asthmatic and healthy subjects after inhalation from a pressurised inhaler and a dry powder inhaler. Thorax 1991, 46(11):817-823.
36. Svartengren K, Philipson K, Svartengren M, Camner P: Effect of adrenergic stimulation on clearance from small ciliated airways in healthy subjects. Exp Lung Res 1998, 24(2):149-158.
37. Klefbeck B, Svartengren K, Camner P, Philipson K, Svartengren M, Sejersen M, Mattsson E: Lung clearance in children with Duchenne muscular dystrophy or spinal muscular atrophy with and without CPAP (continuous positive airway pressure). Exp Lung Res 2001, 27(6):469-484.
38. Geiser M, Baumann M, Cruz-Orive LM, Im Hof V, Waber U, Gehr P: The effect of particle inhalation on macrophage number and phagocytic activity in the intrapulmonary conducting airways of hamsters. Am J Respir Cell Mol Biol 2001, 10(6):594-603.
39. Lay JC, Bennett WD, Kim CS, Devlin RB, Bromberg PA: Retention and intracellular distribution of instilled iron oxide particles in human alveolar macrophages. Am J Respir Cell Mol Biol 1998, 18(5):687-695.
40. Alexis NE, Lay JC, Zeman KL, Geiser M, Kapp N, Bennett WD: In vivo particle uptake by airway macrophages in healthy volunteers. Am J Respir Cell Mol Biol 2006, 34(3):305-313.
41. Alexis NE, Hu SC, Zeman K, Alter T, Bennett WD: Induced sputum derives from the central airways: confirmation using a radiolabeled aerosol bolus delivery technique. Am J Respir Crit Care Med 2001, 164:1964-1970.
42. Mercer RR, Russell ML, Crapo JD: Mucous lining layers in human and rat airways. Annrew Resp Dis 1992, 145:355.
43. Geiser M, Gerber P, Maye I, Im Hof V, Gehr P: Retention of Teflon particles in hamster lungs: a stereological study. J Aerosol Med 2000, 13(1):43-55.
44. Wiebert P, Sanchez-Crespo A, Seitz J, Falk R, Philipson K, Kreyling W, Möller W, Sommerer K, Larsson S, Svartengren M: Negligible clearance of ultrafine particles retained in healthy and affected human lungs. European Respir J in press.