3α-6α-Dihydroxy-7α-fluoro-5β-cholanoate (UPF-680), physicochemical and physiological properties of a new fluorinated bile acid that prevents 17α-ethynyl-estradiol-induced cholestasis in rats

Toxicology and Applied Pharmacology

Volumn 214, Issue 2, 2006, Pages 199-208

  Clerici, Carlo ^a   Castellani, Danilo ^a   Asciutti, Stefania ^a   Pellicciari, Roberto ^a   Setchell, Kenneth D R ^b,c   O'Connell, Nancy C ^b,c   Sadeghpour, Bahman ^a   Camaioni, Emidio ^a   Fiorucci, Stefano ^a   Renga, Barbara ^a   Nardi, Elisabetta ^a   Sabatino, Giuseppe ^a   Clementi, Mattia ^a   Giuliano, Vittorio ^a   Baldoni, Monia ^a   Orlandi, Stefano ^a   Mazzocchi, Alessandro ^a   Morelli, Antonio ^a   Morelli, Olivia ^a  

^a UNIVERSITY OF PERUGIA   (Italy)

^b CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^c UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

Bile acids; Cholestasis; FXR; UDCA; UPF 680

Indexed keywords

3ALPHA,6ALPHA DIHYDROXY 7ALPHA,5BETA CHOLANOATE; BICARBONATE; BILE ACID; BILE ACID CONJUGATE; CHOLIC ACID; ETHINYLESTRADIOL; FLUORINE DERIVATIVE; HYODEOXYCHOLIC ACID; LIPID; LIVER ENZYME; MESSENGER RNA; PHOSPHOLIPID; TAUROCHOLIC ACID; UNCLASSIFIED DRUG; UPF 680; URSODEOXYCHOLIC ACID; 3,6 DIHYDROXY 7 FLUOROCHOLANOIC ACID; 3,6-DIHYDROXY-7-FLUOROCHOLANOIC ACID; CHOLANE DERIVATIVE; CHOLESTEROL 7ALPHA MONOOXYGENASE; DEOXYCHOLIC ACID; DRUG DERIVATIVE; FLUORINATED STEROID; STEROID 12ALPHA MONOOXYGENASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BILE DUCT FISTULA; BILE FLOW; CHOLESTASIS; CHOLESTATIC HEPATITIS; CONJUGATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG BIOAVAILABILITY; DRUG EFFECT; DRUG STABILITY; DRUG SYNTHESIS; FLUORINATION; ISOMER; MALE; NONHUMAN; RAT; ANIMAL; BILE; BILE DUCT; CHEMICAL STRUCTURE; CHEMICALLY INDUCED DISORDER; CHEMISTRY; COMPARATIVE STUDY; DRUG ANTAGONISM; GENETICS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS FRAGMENTOGRAPHY; METABOLISM; MICELLE; SECRETION; SPRAGUE DAWLEY RAT;

FISTULA;

ANIMALS; BILE; BILE DUCTS; CHOLANES; CHOLESTASIS; CHOLESTEROL 7-ALPHA-HYDROXYLASE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DEOXYCHOLIC ACID; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHINYL ESTRADIOL; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; MALE; MICELLES; MOLECULAR STRUCTURE; PHOSPHOLIPIDS; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; STEROID 12-ALPHA-HYDROXYLASE; STEROIDS, FLUORINATED; URSODEOXYCHOLIC ACID;

EID: 33745726161     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2005.12.017     Document Type: Article

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