Different pathophysiological mechanisms of intramitochondrial iron accumulation in acquired and congenital sideroblastic anemia caused by mitochondrial DNA deletion

European Journal of Haematology

Volumn 77, Issue 2, 2006, Pages 169-174

  Matthes, Thomas ^a,d   Rustin, Pierre ^b   Trachsel, Hedwige ^a   Darbellay, Régis ^a   Costaridou, S ^c   Xaidara, A ^c   Rideau, Alexandra ^a   Beris, Photis ^a  

^a UNIVERSITY HOSPITAL   (Switzerland)

^b HÔPITAL NECKER ENFANTS MALADES   (France)

^c AGHIA SOPHIA CHILDREN S HOSPITAL   (Greece)

^d GENEVA UNIVERSITY HOSPITALS   (Switzerland)

Author keywords

Iron metabolism; Mitochondrial DNA; Pearson's disease; Respiratory chain function; Sideroblastic anemia

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATASE 6; ADENOSINE TRIPHOSPHATASE 8; CYTOCHROME C OXIDASE; MITOCHONDRIAL DNA; TRANSFER RNA; UNCLASSIFIED DRUG;

ARTICLE; BONE MARROW; BRAIN; BRAIN DISEASE; CASE REPORT; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENZYME ACTIVITY; ERYTHROBLAST; GENE DELETION; HUMAN; HUMAN CELL; IRON METABOLISM; IRON STORAGE; LIVER; MALE; METABOLIC ACIDOSIS; MITOCHONDRION; MUSCLE WEAKNESS; PANCREAS; PATHOPHYSIOLOGY; PEARSON SYNDROME; PRESCHOOL CHILD; PRIORITY JOURNAL; REFRACTORY ANEMIA WITH EXCESS BLASTS; RESPIRATORY CHAIN; SIDEROBLASTIC ANEMIA; SKELETAL MUSCLE; SPECTROPHOTOMETRY; SYMPTOMATOLOGY;

ACIDOSIS; ADOLESCENT; ANEMIA, REFRACTORY; ANEMIA, SIDEROBLASTIC; BETA-THALASSEMIA; BONE MARROW; CYTOCHROME-C OXIDASE DEFICIENCY; DISEASE PROGRESSION; DNA MUTATIONAL ANALYSIS; DNA, MITOCHONDRIAL; ELECTRON TRANSPORT; ELECTRON TRANSPORT COMPLEX IV; FATAL OUTCOME; GENE DELETION; HETEROZYGOTE; HUMANS; IRON; MALE; MITOCHONDRIA; MITOCHONDRIAL MYOPATHIES; MITOCHONDRIAL PROTON-TRANSLOCATING ATPASES; MOSAICISM; RNA, TRANSFER;

EID: 33745713669     PISSN: 09024441     EISSN: 16000609     Source Type: Journal    
DOI: 10.1111/j.1600-0609.2006.00674.x     Document Type: Article

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