Loading of erythrocyte membrane with pentacyclic triterpenes inhibits Plasmodium falciparum invasion

Planta Medica

Volumn 72, Issue 7, 2006, Pages 640-642

  Ziegler, Hanne L ^a   Staalsø, Trine ^b   Jaroszewski, Jerzy W ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b Mental Health Services CPH   (Denmark)

Author keywords

Antiplasmodial activity; Betulinic acid; Lupeol; Magnetic cell sorting; Malaria

Indexed keywords

BETULIC ACID; CHLOROQUINE; DIMETHYL SULFOXIDE; LUPEOL; TRITERPENOID;

ARTICLE; CELL PROLIFERATION; CELL SELECTION; CONTROLLED STUDY; CULTURE MEDIUM; DRUG DOSE REGIMEN; DRUG INHIBITION; DRUG MECHANISM; ERYTHROCYTE MEMBRANE; HUMAN; INCUBATION TIME; MALARIA; MEROZOITE; PLASMODIUM FALCIPARUM; SPECIES INVASION;

ANIMALS; ANTIMALARIALS; ERYTHROCYTE MEMBRANE; HUMANS; PLASMODIUM FALCIPARUM; TRITERPENES;

PLASMODIUM FALCIPARUM;

EID: 33745712246     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2006-931575     Document Type: Article

References (16)

1. Ziegler HL, Sterk D, Christensen J, Hviid L, Hägerstrand H, Jaroszewski JW. In vitro Plasmodium falciparum drug sensitivity assay: inhibition of parasite growth by incorporation of stomatocytogenic amphiphiles into erythrocyte membrane. Antimicrob Agents Chemother 2002; 46: 1441-6
2. Sairafianpour M, Bahreininejad B, Witt M, Ziegler HL, Jaroszewski JW, Stasrk D. Terpenoids of Salvia hydrangea: Two new, rearranged 20-norabietanes and the effect of oleanolic acid on erythrocyte membranes. Planta Med 2003; 69: 846-50
3. Ziegler HL, Franzyk H, Sairafianpour M, Tabatabai M, Tehrani MD, Bagherzadeh K et al. Erythrocyte membrane modifying agents and the inhibition of Plasmodium falciparum growth: structure-activity relationships for betulinic acid analogues. Bioorg Med Chem 2004; 12: 119-27
4. Paul F, Roath S, Melville D, Warhurst DC, Osisanya JO. Separation of malaria-infected erythrocytes from whole blood: use of a selective high-gradient magnetic separation technique. Lancet 1981; 2: 70-1
5. Miltenyi S, Müller W, Weichel W, Radbruch A. High gradient magnetic cell separation with MACS. Cytometry 1990; 11: 231-8
6. Staalsoe T, Giha HA, Dodoo D, Theander TG, Hviid L. Detection of antibodies to variant antigens on Plasmodium falciparum infected erythrocytes by flow cytometry. Cytometry 1999; 35: 329-36
7. Ziegler HL, Hansen HS, Stærk D, Christensen SB, Hägerstrand H, Jaroszewski JW. The antiparasitic compound licochalcone A is a potent echinocytogenic agent that modifies the erythrocyte membrane in the concentration range where antiplasmodial activity is observed. Antimicrob Agents Chemother 2004; 48: 4067-71
8. Murphy SC, Samuel BU, Harrison T, Speicher KD, Speicher DW, Reid ME et al. Erythrocyte detergent-resistant membrane proteins: their characterization and selective uptake during malarial infection. Blood 2004; 103: 1920-8
9. Parker PD, Tilley L, Klonis N. Plasmodium falciparum induces reorganization of host membrane proteins during intraerythrocytic growth. Blood 2004; 103: 2404-6
10. Thomas SL, Lew VL. Plasmodium falciparum and the permeation pathway of the host red blood cell. Trends Parasitol 2004; 20: 122-5
11. Cooke BM, Mohandas N, Coppel RL. Malaria and the red blood cell membrane. Semin Hematol 2004; 41: 173-88
12. Pei X, An X, Guo X, Tarnawski M, Coppel R, Mohandas N. Structural and functional studies of interaction between Plasmodium falciparum knob-associated histidine-rich protein (KAHRP) and erythrocyte spectrin. J Biol Chem 2005; 280: 31166-71
13. Tiffert T, Lew VL, Ginsburg H, Krugalik M, Croisille L, Mohandas N. The hydration state of human red blood cells and their susceptibility to invasion by Plasmodium falciparum. Blood 2005; 105: 4853-60
14. Nguyen DH, Espinoza JC, Taub DD. Cellular cholesterol enrichment impairs T cell activation and chemotaxis. Mech Ageing Dev 2004; 125: 641-50
15. Breusegem SY, Halaihel N, Inoue M, Zajicek H, Lederer E, Barry NP et al. Acute and chronic changes in cholesterol modulate Na-Pi cotransport activity in OK cells. Am J Physiol Renal Physiol 2005; 289: F154-65
16. Brambillasca S, Yabal M, Soffientini P, Stefanovic S, Makarow M, Hedge RS et al. Transmembrane topogenesis of a tail-anchored protein is modulated by membrane lipid composition. EMBO J 2005; 24: 2533-42