A simple, efficient and highly selective deprotection of t-butyldimethylsilyl (TBDMS) ethers using silica supported sodium hydrogen sulfate as a heterogeneous catalyst

Tetrahedron Letters

Volumn 47, Issue 33, 2006, Pages 5855-5857

  Das, Biswanath ^a   Reddy, K Ravinder ^a   Thirupathi, P ^a  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

Author keywords

Chemoselectivity; Deprotection; Heterogeneous catalyst; NaHSO4 SiO2; TBDMS ethers

Indexed keywords

ETHER DERIVATIVE; SILICON DIOXIDE; SULFATE;

ARTICLE; CATALYST; CHEMICAL PROCEDURES; CHEMICAL REACTION; DEPROTECTION REACTION; REACTION ANALYSIS; ROOM TEMPERATURE;

EID: 33745698149     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2006.06.088     Document Type: Article

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18. 2 (10 ml) was stirred at room temperature for 30 min (TLC indicated completion of the reaction). The catalyst was removed by filtration and washed with EtOAc (2 × 5 ml). The filtrate and washings were combined and the solvents removed. The residue was subjected to column chromatography (silica gel, hexane-EtOAc) to yield the parent alcohol.