Hepatocellular adenoma: Malignancy potential and differentiation from hepatocellular carcinoma;Leberzelladenom. Entartungspotenzial und abgrenzung vom hepatozellulären karzinom

Pathologe

Volumn 27, Issue 4, 2006, Pages 238-243

  Flemming, P ^a   Lehmann, U ^b   Steinemann, D ^b   Kreipe, H ^b   Wilkens, L ^b  

^a Pathologisches Institut   (Germany)

^b HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Degeneration; Hepatocellular adenoma (HCA); Hepatocellular carcinoma (HCC); Liver tumor

Indexed keywords

ADENOMATOSIS; ARTICLE; COMPARATIVE STUDY; DIFFERENTIAL DIAGNOSIS; HISTOPATHOLOGY; HORMONAL THERAPY; HUMAN; LIVER ADENOMA; LIVER CELL CARCINOMA; PRECANCER; PREMENOPAUSE; RISK FACTOR; STANDARD; TUMOR DIFFERENTIATION;

ADENOMA; ADULT; CARCINOMA, HEPATOCELLULAR; DIAGNOSIS, DIFFERENTIAL; HUMANS; LIVER NEOPLASMS; MIDDLE AGED;

EID: 33745684095     PISSN: 01728113     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00292-006-0835-0     Document Type: Article

References (39)

1. Bala S, Wunsch PH, Ballhausen WG (1997) Childhood hepatocellular adenoma in familial adenomatous polyposis: mutations in adenomatous polyposis coli gene and p53. Gastroenterology 112: 919-922
2. Bianchi L (1993) Glycogen storage disease I and hepatocellular tumours. Eur J Pediat; 152 Suppl 1: S63-S70 (review)
3. Bioulac-Sage P, Rebouissou S, Sa Cunha A et al. (2005) Clinical, morphologic, and molecular features defining so-called telangiectatic focal nodular hyperplasias of the liver. Gastroenterology 128: 1211-1218
4. Chen YJ, Chen PJ, Lee MC et al. (2002) Chromosomal analysis of hepatic adenoma and focal nodular hyperplasia by comparative genomic hybridization. Genes Chromosomes Cancer 35: 138-143
5. Chen YW, Jeng YM, Yeh SH, Chen PJ (2002) P53 gene and Wnt signaling in benign neoplasms: beta-catenin mutations in hepatic adenoma but not in focal nodular hyperplasia. Hepatology 36: 927-935
6. Ferrell LD (1993) Hepatocellular carcinoma arising in a focus of multilobular adenoma. A case report. Am J Surg Pathol 17: 525-529
7. Ferrell LD, Crawford JM, Dhillon AP et al. (1993) Proposal for standardized criteria for the diagnosis of benign, borderline, and malignant hepatocellular lesions arising in chronic advanced liver disease. Am J Surg Pathol 17: 1113-1123
8. Flemming P, Wilkens L, Kreipe HH (2000) Histopathological diagnosis of primary liver tumors. Pathologe 22: 184-190
9. Foster JH, Berman MM (1993) The malignant transformation of liver cell adenomas. Arch Surg 129: 712-717 (review)
10. Goldfarb S (1976) Sex hormones and hepatic neoplasia. Cancer Res 36: 2584-2588
11. Gordon SC, Reddy KR, Livingstone AS et al. (1986) Resolution of a contraceptive-steroid-induced hepatic adenoma with subsequent evolution into hepatocellular carcinoma. Ann Intern Med 105: 547-549
12. Grazioli L, Federle MP, Ichikawa T et al. (2000) Liver adenomatosis: clinical, histopathologic, and imaging findings in 15 patients. Radiology 216: 395-402
13. Gyorffy EJ, Bredfeldt JE, Black WC (1989) Transformation of hepatic cell adenoma to hepatocellular carcinoma due to oral contraceptive use. Ann Intern Med 110: 489-490
14. Heinemann LA, Weimann A, Gerken G et al. (1998) Modern oral contraceptive use and benign liver tumors: the German Benign Liver Tumor Case-Control Study. Eur J Contracept Reprod Health Care 3: 194-200
15. Herman P, Machado MA, Volpe P et al. (1994)Transformation of hepatic adenoma into hepatocellular carcinoma in patients with prolonged use of oral contraceptives. Rev Hosp Clin Fac Med Sao Paulo 49: 30-33
16. Ito M, Sasaki M, Wen CY et al. (2003) Liver cell adenoma with malignant transformation: a case report. World J Gastroenterol 9: 2379-2381
17. Janes CH, McGill DB, Ludwig J, Krom RA (1993) Liver cell adenoma at the age of 3 years and transplantation 19 years later after development of carcinoma: a case report. Hepatology 17: 583-585
18. Kusano N, Shiraishi K, Kubo K et al. (1999) Genetic aberrations detected by comparative genomic hybridization in hepatocellular carcinomas: their relationship to clinicopathological features. Hepatology 29: 1858-1862
19. Lack EE, Neave C, Vawter GF (1983) Hepatocellular carcinoma. Review of 32 cases in childhood and adolescence. Cancer 52: 1510-1515
20. Leese T, Farges O, Bismuth H (1988) Liver cell adenomas. A 12-year surgical experience from a specialist hepato-biliary unit. Ann Surg 208: 558-564
21. Lehmann U, Berg-Ribbe I, Wingen LU et al. (2005) Distinct methylation patterns of benign and malignant liver tumors revealed by quantitative methylation profiling. Clin Cancer Res 11: 3654-3660
22. Perret AG, Mosnier JF, Porcheron J et al. (1996) Role of oral contraceptives in the growth of a multilobular adenoma associated with a hepatocellular carcinoma in a young woman. J Hepatol 25: 976-979
23. Scott FR, El-Refaie A, More L et al. (1996) Hepatocellular carcinoma arising in an adenoma: value of QBend 10 immunostaining in diagnosis of liver cell carcinoma. Histopathology 28: 472-474
24. Takayasu H, Motoi T, Kanamori Y et al. (2002) Two case reports of childhood liver cell adenomas harboring beta-catenin abnormalities. Hum Pathol 33: 852-855
25. Tannapfel A, Busse C, Geissler F et al. (2002) INK4a-ARF alterations in liver cell adenoma. Gut 51: 253-258
26. Tao LC (1991) Oral contraceptive-associated liver cell adenoma and hepatocellular carcinoma. Cytomorphology and mechanism of malignant transformation. Cancer 68: 341-347
27. Terkivatan T, de Wilt JH, de Man RA et al. (2001) Indications and long-term outcome of treatment for benign hepatic tumors: a critical appraisal. Arch Surg 136: 1033-1038
28. Terracciano L, Tornillo L (2003) Cytogenetic alterations in liver cell tumors as detected by comparative genomic hybridization. Pathologica 95: 71-82 (review)
29. Terracciano LM, Tornillo L, Avoledo P et al. (2004) Fibrolamellar hepatocellular carcinoma occurring 5 years after hepatocellular adenoma in a 14-year-old girl: a case report with comparative genomic hybridization analysis. Arch Pathol Lab Med 128: 222-226
30. Tesluk H, Lawrie J (1981) Hepatocellular adenoma. Its transformation to carcinoma in a user of oral contraceptives. Arch Pathol Lab Med 105: 296-299
31. Torbenson M, Lee JH, Choti M et al. (2002) Hepatic adenomas: analysis of sex steroid receptor status and the Wnt signaling pathway. Mod Pathol 15: 189-196
32. Weimann A, Fronhoff K, Gratz KF et al. (1998) Diagnostic and therapeutic strategies in hepatocellular adenoma. Zentralbl Chir 123: 140-144
33. Wilkens L, Bredt M, Flemming P et al. (2001 a) Diagnostic impact of fluorescence in situ hybridization in the differentiation of hepatocellular adenoma and well-differentiated hepatocellular carcinoma. J Mol Diagn 3: 68-73
34. Wilkens L, Bredt M, Flemming P et al. (2001) Differentiation of liver cell adenomas from well-differentiated hepatocellular carcinomas by comparative genomic hybridization (2001 b). J Pathol 193: 476-482
35. Steinemann D, Skawran B, Becker T et al. (2006) Assessment of differentiation and progression of hepatic tumors using arraybased comparative genomic hybridization. Clin Gasto Hepatol (im Druck)
36. Wilkens L, Bredt M, Flemming A et al. (2002 b) Detection of chromosomal aberrations in well-differentiated hepatocellular carcinoma by bright-field in situ hybridization. Mod Pathol 15: 470-475
37. Wilkens L, Flemming P, Gebel M et al. (2004) Induction of aneuploidy by increasing chromosomal instability during dedifferentiation of hepatocellular carcinoma. Proc Natl Acad Sci USA 101: 1309-1314
38. Wilkens L, Becker T, Schlegel berger B et al. (2006) Preserved reticulin network in a case of hepatocellular carcinoma. Histopathology (in press)
39. Zucman-Rossi J (2004) Genetic alterations in hepatocellular adenomas: recent findings and new challenges. J Hepatol 40: 1036-1039 (review)