The potassium channel opener levcromakalim causes expansive remodelling of experimental vein grafts

Journal of Vascular Surgery

Volumn 44, Issue 1, 2006, Pages 159-165

  Wales, Lucy ^a   Gosling, Martin ^a   Taylor, Graham W ^b   Davies, Alun H ^a   Powell, Janet T ^a  

^a CHARING CROSS HOSPITAL   (United Kingdom)

^b ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BROXURIDINE; LEMAKALIM; PLACEBO; POTASSIUM CHANNEL STIMULATING AGENT;

ANIMAL EXPERIMENT; AORTA SURGERY; ARTERIOVENOUS SHUNT; ARTICLE; CAVA VEIN; CELL DENSITY; COHORT ANALYSIS; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG EFFECT; DRUG HALF LIFE; INTIMA; MALE; MORPHOMETRICS; NONHUMAN; OSMOTIC PUMP; PERFUSION; PRESSURE; PRIORITY JOURNAL; RAT; STAINING; TUNICA MEDIA; VEIN GRAFT;

EID: 33745668855     PISSN: 07415214     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jvs.2006.02.063     Document Type: Article

References (30)

1. Szilagyi D.E., Elliott J.P., Hageman J.H., Smith R.F., and Dall'olmo C.A. Biologic fate of autogenous vein implants as arterial substitutes. clinical, angiographic and histopathologic observations in femoro-popliteal operations for atherosclerosis. Ann Surg 178 (1973) 232-246
2. Berczi V., Greene A.S., Dornyei G., Csengbody J., Hodi G., Kadar A., et al. Venous myogenic tone. studies in human and canine vessels. Am J Physiol 263 (1992) H1315-H1320
3. McCollum C., Alexander C., Kenchington G., Franks P.J., and Greenhalgh R. Antiplatelet drugs in femoropopliteal vein bypasses. a multicenter trial. J Vasc Surg 13 (1991) 150-161
4. Davies M.G., and Hagen P.O. Pathophysiology of vein graft failure. a review. Eur J Vasc Endovasc Surg 9 (1995) 7-18
5. Norman P.E., and House A.K. Influence of prazosin on experimental vein graft intimal thickening. Br J Surg 79 (1992) 276-279
6. Hoch J.R., Stark V.K., van Rooijen N., Kim J.L., Nutt M.P., and Warner T.F. Macrophage depletion alters vein graft intimal hyperplasia. Surgery 126 (1999) 428-437
7. Yamanouchi D., Banno H., Nakayama M., Sugimoto M., Fujita H., Kobayashi M., et al. Hydrophilic statin suppresses vein graft intimal hyperplasia via endothelial cell-tropic Rho-kinase inhibition. J Vasc Surg 42 (2005) 757-764
8. Angelini G.D., Izzat M.B., Bryan A.L., and Newby A.C. External stenting reduces early medial and neointimal thickening in a pig model of arteriovenous bypass grafting. J Thorac Cardiovasc Surg 112 (1996) 79-84
9. Mehta D., George S.J., Jeremy J.Y., Izzat M.B., Southgate K.M., Bryan A.J., et al. External stenting reduces long-term medial and neointimal thickening and platelet derived growth factor expression in a pig model of arteriovenous bypass grafting. Nat Med 4 (1998) 235-239
10. Amano J., Suzuki A., Sunamori M., Tsukada T., and Numano F. Cytokinetic study of aortocoronary bypass vein grafts in place for less than six months. Am J Cardiol 67 (1991) 1234-1236
11. Hoch J.R., Stark V.K., and Turnipseed W.D. The temporal relationship between the development of vein graft intimal hyperplasia and growth factor gene expression. J Vasc Surg 22 (1995) 51-58
12. Lara M., and Miller V.M. Early remodelling of saphenous vein grafts. proliferation, migration and apoptosis of adventitial and medial cells occur simultaneously with changes in graft diameter and flow. J Vasc Res 37 (2000) 576-584
13. Fernandez C.M., Goldman D.R., Jiang Z., Ozaki C.K., Tran-Son-Tay R., and Berceli S.A. Impact of shear stress on early vein graft remodeling. a biomechanical analysis. Ann Biomed Eng 32 (2004) 1484-1493
14. Beattie D.K., Gosling M., Davies A.H., and Powell J.T. The effects of potassium channel openers on saphenous vein exposed to arterial flow. Eur J Vasc Endovasc Surg 13 (1998) 244-249
15. ATP channel in rat and bovine pulmonary vascular endothelial cells. Am J Cell Physiol 285 (2003) C959-C967
16. ATP channels in vascular smooth muscles. Circ Res 92 (2003) 1225-1232
17. Sterpetti A.V., Cucina A., Lepidi S., Randone B., Stipa F., Aromatario C., et al. Progression and regression of myointimal hyperplasia in experimental vein grafts depends on platelet-derived growth factor and basic fibroblast growth factor production. J Vasc Surg 23 (1996) 568-575
18. Weaver J.R., and Au J.L. Comparative scoring by visual and image analysis of cells in human solid tumors labeled for proliferation markers. Cytometry 27 (1997) 189-199
19. Torsney E., Mayr U., Zou Y., Thompson W.D., Hu Y., and Xu Q. Thrombosis and neointima formation in vein grafts are inhibited by locally applied aspirin through endothelial protection. Circ Res 94 (2004) 1466-1473
20. Mureebe L., Turnquist S.E., and Silver D. Inhibition of intimal hyperplasia by direct thrombin inhibitors in an animal vein bypass model. Ann Vasc Surg 18 (2004) 147-150
21. Goldman J., Zhong L., and Liu S.Q. Degradation of alpha-actin filaments in venous smooth muscle cells in response to mechanical stretch. Am J Physiol Heart Circ Physiol 284 (2003) H1839-H1847
22. Driss A.B., Benessiano J., Poitevin P., Levy B.I., and Michel J.-B. Arterial expansive remodelling induced by high flow rates. Am J Physiol 272 (1997) H851-H858
23. Murphy G.J., and Angelin G.D. Insights into the pathogenesis of vein graft disease. lessons from intravascular ultrasound. Cardiovasc Unltrasound 2 (2004) 8
24. Berceli S.A., Jiang Z., Klingman N.V., Pfahnl C.L., Abouhamze Z.S., Frase C.D., et al. Differential expression and activity of matrix metalloproteinases during flow-modulated vein graft remodeling. J Vasc Surg 39 (2004) 1084-1090
25. Chung A.W., Rauniyar P., Luo H., Hsiang Y.N., van Breemen C., and Okon E.B. Pressure distention compared with pharmacologic relaxation in vein grafting upregulates matrix metalloproteinase-2 and -9. J Vasc Surg 42 (2005) 747-756
26. Sharony R., Pintucci G., Saunders P.C., Grossi E.A., Baumann F.G., Galloway A.C., et al. Matrix metalloproteinase expression in vein grafts. role of inflammatory mediators and extracellular signal-regulated kinases-1 and -2. Am J Physiol Heart Circ Physiol 290 (2006) H1651-H1659
27. Rotmans J.I., Velema E., Verhagen H.J., Blankensteijn J.D., de Kleijn D.P., Stroes E.S., et al. Matrix metalloproteinase inhibition reduces intimal hyperplasia in a porcine arteriovenous-graft model. J Vasc Surg 39 (2004) 432-439
28. Zhang L., Hagen P.O., Kisslo J., Peppel K., and Freedman N.J. Neointimal hyperplasia rapidly reaches steady state in a novel murine vein graft model. J Vasc Surg 36 (2002) 824-832
29. Dobrin P.B., Littooy F.N., Golan J., Blakeman B., and Fareed J. Mechanical and histologic changes in canine vein grafts. J Surg Res 44 (1988) 259-265
30. Lardenoye J.H., De Vries M.R., Grimbergen J.M., Havekes L.M., Xu Q., Dhore C.R., et al. Inhibition of accelerated atherosclerosis in vein grafts by placement of external stent in apoE*3-Leiden transgenic mice. Arterioscler Thromb Vasc Biol 22 (2002) 1433-1438