Positive end-expiratory pressure ventilation increases extravascular lung water due to a decrease in lung lymph flow

Anaesthesia and Intensive Care

Volumn 34, Issue 3, 2006, Pages 329-333

  Maybauer, Dirk M ^a,e   Talkes, P O ^b   Westphal, M ^c   Maybauer, M O ^a   Traber, L D ^d   Enkhbaatar, P ^d   Morita, N ^d   Traber, D L ^d  

^a UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF MÜNSTER   (Germany)

^d IICU   (Germany)

^e UNIVERSITY HOSPITAL ULM   (Germany)

Author keywords

Cardiac output; Extravascular lung water; Lymph flow; Positive end expiratory pressure; Sheep

Indexed keywords

HALOTHANE; KETAMINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL GAS; ARTICLE; ARTIFICIAL VENTILATION; CARDIOPULMONARY FUNCTION; CONTROLLED STUDY; FEMALE; FUNCTIONAL RESIDUAL CAPACITY; HEART OUTPUT; HEMODYNAMICS; LUNG ARTERIOVENOUS SHUNT; LUNG CIRCULATION; LUNG EXTRAVASCULAR FLUID; LUNG GAS EXCHANGE; LUNG LYMPH FLOW; NONHUMAN; POSITIVE END EXPIRATORY PRESSURE; PROSPECTIVE STUDY; RESPIRATORY FAILURE; SYSTEMIC CIRCULATION; TRACHEOSTOMY;

EID: 33745645388     PISSN: 0310057X     EISSN: None     Source Type: Journal    
DOI: 10.1177/0310057x0603400307     Document Type: Article

References (33)

1. Wickerts CJ, Berg B, Blomqvist H. Influence of positive end-expiratory pressure on extravascular lung water during the formation of experimental hydrostatic pulmonary oedema. Acta Anaesthesiol Scand 1992; 36:309-317.
2. Dinger J, Peter-Kern M, Goebel P et al. Effect of PEEP and suction via chest drain on functional residual capacity and lung compliance after surgical repair of congenital diaphragmatic hernia: preliminary observations in 5 patients. J Pediatr Surg 2000; 35:1482-1488.
3. Duncan AW, Oh TE, Hillmann DR. PEEP and CPAP. Anaesth Intensive Care 1986; 14:236-250.
4. Clarke JP, Schuitemaker MN, Sleigh JW. The effect of intraoperative ventilation strategies on perioperative, atelectasis. Anaesth Intensive Care 1998; 26:262-266.
5. Szakmany T, Heigl P, Molnar Z. Correlation between extravascular lung water and oxygenation in ALI/ARDS patients in septic shock: possible role in the development of atelectasis? Anaesth Intensive Care 2004; 32:196-201.
6. Miller WC, Rice DL, Unger KM, Bradley BL. Effect of PEEP on lung water content in experimental noncardiogenic pulmonary edema. Crit Care Med 1981; 9:7-9.
7. Kato M, Otsuki M, Wang LQ et al. [Effect of positive end-expiratory pressure on respiration and hemodynamics in dogs with pulmonary edema caused by increased membrane permeability]. Masui 1998; 47:9-21. [Japanese]
8. Colmenero-Ruiz M, Fernandez-Mondejar E, Fernandez-Sacristan MA et al. PEEP and low tidal volume ventilation reduce lung water in porcine pulmonary edema. Am J Respir Crit Care Med 1997; 155:964-970.
9. Carlile PV, Lowery DD, Gray BA. Effect of PEEP and type of injury on thermal-dye estimation of pulmonary edema. J Appl Physiol 1986; 60:22-31.
10. DeMarino S, Olson LE, Pou NA et al. Optical and radioisotope indicator dilution measurements in pulmonary edema. Ann Biomed Eng 1998; 26:417-430.
11. Maybauer DM, Salsbury JR, Westphal M et al. The ATP-sensitive potassium-channel inhibitor glibenclamide improves outcome in an ovine model of hemorrhagic shock. Shock 2004; 22:387-391.
12. Maybauer MO, Kikuchi Y, Westphal M et al. Effects of manganese superoxide dismutase nebulization on pulmonary function in an ovine model of acute lung injury. Shock 2005; 23:138-143.
13. Westphal M, Noshima S, Isago T et al. Selective thromboxane A2 synthase inhibition by OKY-046 prevents cardiopulmonary dysfunction after ovine smoke inhalation injury. Anesthesiology 2005; 102:954-961.
14. Staub NC, Bland RD, Brigham KL et al. Preparation of chronic lung lymph fistulas in sheep. J Surg Res 1975; 19:315-320.
15. Demling RH, Gunther R. Effect of diaphragmatic lymphatic contamination on caudal mediastinal node lymph flow in unanesthetized sheep. Lymphology 1982; 15:163-167.
16. Runciman WB, Ilsley AH, Roberts JG. An evaluation of thermodilution cardiac output measurement using the Swan-Ganz catheter. Anaesth Intensive Care 1981; 9:208-220.
17. Enderson BL, Rice C, Moss GS. Effect of positive-end expiratory prespure on accuracy of thermal-dye measurements of lung water. J Surg Res 1985; 38:224-230.
18. Murakami K, Bjertnaes LJ, Schmalstieg FC et al. A novel animal model of sepsis after acute lung injury in sheep. Crit Care Med 2002; 30:2083-2090.
19. Maybauer MO, Maybauer DM, Traber LD et al. Gentamicin improves hemodynamics in ovine septic shock following smoke inhalation injury. Shock 2005; 24:226-231.
20. Allen SJ, Drake RE, Laine GA, Gabel JC. Effect of thoracic duct drainage on hydrostatic pulmonary edema and pleural effusion in sheep. J Appl Physiol 1991; 71:314-316.
21. Haider M, Schad H, Mendler N. Thoracic duct lymph and PEEP studies in anaesthetized dogs. I. Lymph formation and the effect of a thoracic duct fistula on lymph flow. Intensive Care Med 1987; 13:183-191.
22. Hasan FM, Beller TA, Sobonya RE et al. Effect of positive end-expiratory pressure and body position in unilateral lung injury. J Appl Physiol 1982; 52:147-154.
23. Martin GS, Eaton S, Mealer M, Moss M. Extravascular lung water in patients with severe sepsis: a prospective cohort study. Crit Care 2005; 9:R74-R82.
24. Fernandez Mondejar ME, Vazquez Mata MG, Cardenas A et al. Ventilation with positive end-expiratory pressure reduces extravascular lung water and increases lymphatic flow in hydrostatic pulmonary edema. Crit Care Med 1996; 24:1562-1567.
25. Slama K, Gesch M, Bock JC et al. Unilateral lung edema: effects on pulmonary gas exchange, hemodynamics, and pulmonary perfusion distribution. J Appl Physiol 2000; 89:1513-1521.
26. Walther SM, Domino KB, Glenny RW, Hlastala MP. Positive end-expiratory pressure redistributes perfusion to dependent lung regions in supine but not in prone lambs. Crit Care Med 1999; 27:37-45.
27. Slutsky RA. Reduction in pulmonary blood volume during positive end-expiratory pressure. J Surg Res 1983; 35:181-187.
28. Yamada T, Takeda J, Satoh M et al. Effect of positive end-expiratory pressure on left and right ventricular diastolic filling assessed by transoesophageal Doppler echocardiography. Anaesth Intensive Care 1999; 27:341-345.
29. Jardin F, Farcot JC, Boisante L et al. Influence of positive end-expiratory pressure on left ventricular performance. N Engl J Med 1981; 304:387-392.
30. Henning RJ. Effects of positive end-expiratory pressure on the right ventricle. J Appl Physiol 1986; 61:819-826.
31. Luecke T, Roth H, Herrmann P et al. PEEP decreases atelectasis and extravascular lung water but not lung tissue volume in surfactant-washout lung injury. Intensive Care Med 2003; 29:2026-2033.
32. Ruiz-Bailen M, Fernandez-Mondejar E, Hurtado-Ruiz B et al. Immediate application of positive-end expiratory pressure is more effective than delayed positive-end expiratory pressure to reduce extravascular lung water. Crit Care Med 1999; 27:380-384.
33. van der Zee H, Cooper JA, Hakim TS, Malik PB. Alterations in pulmonary fluid balance induced by positive end-expiratory pressure. Respir Physiol 1986; 64:125-133.