Structural and Kinetic Analysis of Caspase-3 Reveals Role for S5 Binding Site in Substrate Recognition

Journal of Molecular Biology

Volumn 360, Issue 3, 2006, Pages 654-666

  Fang, Bin ^a   Boross, Peter I ^b   Tozser, Jozsef ^b   Weber, Irene T ^a  

^a GEORGIA STATE UNIVERSITY   (United States)

^b UNIVERSITY OF DEBRECEN   (Hungary)

Author keywords

apoptosis; cysteine protease; enzyme catalysis; induced fit

Indexed keywords

ACETYLASPARTYLGLUTAMYLVALYLASPARTIC ACID 4 NITROANILIDE; ACETYLASPARTYLGLUTAMYLVALYLASPARTIC ACID ALDEHYDE; ACETYLASPARTYLMETHIONYLGLUTAMINYLASPARTIC ACID 4 NITROANILIDE; ACETYLASPARTYLMETHIONYLGLUTAMINYLASPARTIC ACID ALDEHYDE; ACETYLVALYLASPARTYLVALYLALANYLASPARTIC ACID 4 NITROANILIDE; ACETYLVALYLASPARTYLVALYLALANYLASPARTIC ACID ALDEHYDE; AMINO ACID DERIVATIVE; CASPASE 2; CASPASE 3; CASPASE 3 INHIBITOR; CASPASE 7; CASPASE 8; CASPASE 9; CYSTEINE PROTEINASE; INTERLEUKIN 1BETA CONVERTING ENZYME; LEUCINE; PEPTIDE DERIVATIVE; PHENYLALANINE; PROTEIN DERIVATIVE; PROTEIN INHIBITOR; UNCLASSIFIED DRUG; VALINE;

APOPTOSIS; ARTICLE; BINDING SITE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME KINETICS; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; HYDROLYSIS; HYDROPHILICITY; HYDROPHOBICITY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION; PROTEIN LOCALIZATION;

EID: 33745644229     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2006.05.041     Document Type: Article

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