Analysis of DNA mismatch repair gene expression and mutations in thyroid tumours

Anticancer Research

Volumn 26, Issue 3 A, 2006, Pages 2107-2112

  Ruschenburg, Ilka ^a   Vollheim, Beate ^b   Stachura, Jerzy ^c   Cordon Cardo, Carlos ^d   Korabiowska, Monika ^b,e  

^a Cytological Laboratory   (Germany)

^b UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

^c JAGIELLONIAN UNIVERSITY   (Poland)

^d MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^e Reinhard Nieter Krankenhaus Stadtische Kliniken gGmbH   (Germany)

Author keywords

DNA mismatch repair; MLH1; MSH2; PMS1; PMS2; Thyroid cancer

Indexed keywords

MISMATCH REPAIR PROTEIN PMS1; MISMATCH REPAIR PROTEIN PMS2; NUCLEIC ACID BINDING PROTEIN; PROTEIN MLH1; PROTEIN MSH2; UNCLASSIFIED DRUG;

ADENOMA; ADULT; AGED; ARTICLE; FEMALE; FOLLICULAR CARCINOMA; GENE EXPRESSION; HUMAN; MAJOR CLINICAL STUDY; MALE; MISMATCH REPAIR; NODULAR HYPERPLASIA; POINT MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; THYROID FOLLICLE; THYROID TUMOR;

ADENOCARCINOMA, FOLLICULAR; ADENOMA; ADENOSINE TRIPHOSPHATASES; ADOLESCENT; ADULT; AGED; BASE PAIR MISMATCH; BASE SEQUENCE; CARCINOMA, PAPILLARY; CARRIER PROTEINS; DNA REPAIR; DNA REPAIR ENZYMES; DNA-BINDING PROTEINS; FEMALE; GENE EXPRESSION; HUMANS; HYPERPLASIA; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; MUTATION; MUTS HOMOLOG 2 PROTEIN; NEOPLASM INVASIVENESS; NEOPLASM PROTEINS; NUCLEAR PROTEINS; THYROID GLAND; THYROID NEOPLASMS;

EID: 33745634378     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Bronner CE, Baker SM, Morrison PT et al: Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary nonpolyposis colorectal cancer. Nature 368: 258-261, 1994.
2. Fishel R, Lescoe MK, Rao MR et al: The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colorectal cancer. Cell 75: 1027-1038, 1993.
3. Hemminki A, Peltomaki P and Mecklin JP: Loss of the wild type MLH1 gene is a feature of hereditary nonpolyposis colorectal cancer. Nat Genet 8: 405-410, 1994.
4. Leach FS, Nicolaides NC, Papadopoulos N et al: Mutations of MutS homolog in hereditary nonpolyposis colorectal cancer. Cell 75: 1215-1225, 1993.
5. Nicolaides NC, Papadopoulos N, Liu B et al: Mutations of two PMS homologues in hereditary nonpolyposis colorectal cancer. Nature 371: 75-80, 1994.
6. Papadopoulos N and Lindblom A: Molecular basis of HNPCC: mutations of MMR genes. Hum Mutat 10: 89-99, 1997.
7. Papadopoulos N, Nicolaides NC, Wie YF et al: Mutations of a mutL homolog in hereditary colon cancer. Science 263: 1625-1629, 1994.
8. Korabiowska M, Brinck U, Dengler H et al: Analysis of the DNA mismatch repair in malignant melanomas. Anticancer Res 20: 4499-4506, 2000.
9. Korabiowska M, Brinck U, Kotthaus I et al: Comparative study of DNA mismatch repair genes, APC and GADD genes in melanoma recurrences and metastases. Melanoma Res 10: 537-544, 2000.
10. Paulson G, Wright FA, Parker BA et al: Microsatellite instability correlates with reduced survival and poor disease prognosis in breast cancer. Cancer Res 56: 4021-4026, 1996.
11. Thykjaer T, Christensen M, Clark AB et al: Functional analysis of the mismatch repair system in bladder cancer. Br J Cancer 85: 568-575, 2001.
12. Furihata M, Takeuchi T, Ohtsuki Y et al: Genetic analysis of hMLH1 in transitional cell carcinoma of the urinary bladder. J Urol 165: 1760-1764, 2001.
13. Dobosz T, Lukienczuk T, Sasiadek M et al: Microsatellite instability in thyroid papillary carcinoma and multinodular hyperplasia. Oncology 58: 305-310, 2000.
14. Richter HE, Lohrer HD, Hieber L et al: Microsatellite instability and loss of heterozygosity in radiation associated thyroid carcinomas of Belarussian children and adults. Carcinogenesis 20: 2247-2252, 1999.
15. Kok K, Naylor SL and Buys CH: Deletion of the short arm of chromosome 3 in solid tumors and the search for suppressor genes. Adv Cancer Res 71: 27-92, 1997.
16. Auer GU, Bäckdahl M, Forsslund et al: Ploidy levels in nonneoplastic and neoplastic thyroid cells. Anal Quant Cytol Histol 7: 97-106, 1985.
17. Bäckdahl M, Carstensen J, Auer G et al: Statistical evaluation of the prognostic value of nuclear DNA content in papillary, follicular and medullary thyroid tumours. World J Surg 10: 974-980, 1986.
18. Boon ME and Kok LP: An explanation for the reported variablility of nuclear areas in air dried Romanowky-Giemsa stained smears of the follicular tumours of the thyroid. Acta Cytol 31: 527-530, 1987.
19. Bonn ME, Löwhagen T, Cardozo PL et al: Computation of preoperative diagnosis probability for follicular adenoma and carcinoma of the thyroid on aspiration smears. Analyt Quant Cytol 4: 1-5, 1982.
20. Lee TK, Meyers RT, Bond MG et al: The significance of nuclear diameter in the biologic behaviour of thyroid carcinomas. A retrospective study of 127 cases. Hum Pathol 18: 1252-1256, 1987.
21. Korabiowska M, Ruschenburg I, Schlott T et al: Relation between ploidy status and the expression of the DNA mismatch repair genes in cytological specimens of melanoma metastases. Diagn Cytopathol 24: 157-162, 2000.