Klotho, an important new factor for the activity of Ca2+ channels, connecting calcium homeostasis, ageing and uraemia

Nephrology Dialysis Transplantation

Volumn 21, Issue 7, 2006, Pages 1770-1772

  Lewin, Ewa ^a   Olgaard, Klaus ^a  

^a GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Calcium channels; Klotho; TRPV5

Indexed keywords

ADENOSINE TRIPHOSPHATASE (CALCIUM); BETA GLUCURONIDASE; CALBINDIN; CALCITONIN; CALCITRIOL; CALCIUM; CALCIUM CHANNEL; COMPLEMENTARY DNA; ESTROGEN; KLOTHO PROTEIN; PARATHYROID HORMONE; TRANSIENT RECEPTOR POTENTIAL CHANNEL; UNCLASSIFIED DRUG; VITAMIN D;

AGING; ARTERIOSCLEROSIS; BLOOD CLOTTING; BONE DENSITY; CALCIUM ABSORPTION; CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; CALCIUM TRANSPORT; CELL MEMBRANE; EPITHELIUM CELL; GENE MUTATION; GENETIC POLYMORPHISM; HOMOZYGOSITY; HUMAN; HYPERCALCEMIA; INFERTILITY; LIFESPAN; NONHUMAN; NOTE; OSTEOPOROSIS; POSTMENOPAUSE; PRIORITY JOURNAL; RNA SPLICING; SECOND MESSENGER; SKIN ATROPHY; UREMIA; VITAMIN D INTOXICATION;

AGING; ANIMALS; CALCIUM; CALCIUM CHANNELS; CELL MEMBRANE; GLUCURONIDASE; HOMEOSTASIS; HUMANS; KIDNEY DISEASES; MODELS, BIOLOGICAL; UREMIA;

EID: 33745632035     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfl178     Document Type: Note

References (26)

1. Shanahan CM. Vascular calcification. Curr Opin Nephrol Hypertens 2005; 14: 361-367
2. Reynolds JL, Skepper JN, McNair R et al. Multifunctional roles for serum protein fetuin-a in inhibition of human vascular smooth muscle cell calcification. J Am Soc Nephrol 2005; 16: 2920-2930
3. Goodman WG, London G, Amann K et al. Vascular calcification in chronic kidney disease. Am J Kidney Dis 2004; 43: 572-579
4. Seeman E. Estrogen, androgen, and the pathogenesis of bone fragility in women and men. Curr Osteoporos Rep 2004; 2: 90-96
5. Arking DE, Krebsova A, Macek M,Sr et al. Association of human aging with a functional variant of klotho. Proc Natl Acad Sci USA 2002; 99: 856-861
6. Tsujikawa H, Kurotaki Y, Fujimori T, Fukuda K, Nabeshima Y. Klotho, a gene related to a syndrome resembling human premature aging, functions in a negative regulatory circuit of vitamin D endocrine system. Mol Endocrinol 2003; 17: 2393-2403
7. Sugiura H, Yoshida T, Tsuchiya K et al. Klotho reduces apoptosis in experimental ischaemic acute renal failure. Nephrol Dial Transplant 2005; 20: 2636-2645
8. Koh N, Fujimori T, Nishiguchi S et al. Severely reduced production of klotho in human chronic renal failure kidney. Biochem Biophys Res Commun 2001; 280: 1015-1020
9. Chang Q, Hoefs S, van der Kemp AW et al. The beta-glucuronidase klotho hydrolyzes and activates the TRPV5 channel. Science 2005; 310: 490-493
10. 2+ and other ions as extracellular (first) messengers. Physiol Rev 1991; 71: 371-411
11. Pozzan T, Rizzuto R, Volpe P, Meldolesi J. Molecular and cellular physiology of intracellular calcium stores. Physiol Rev 1994; 74:595-636
12. Markowitz M, Rotkin L, Rosen JF. Circadian rhythms of blood minerals in humans. Science 1981; 213: 672-674
13. Brown EM, Gamba G, Riccardi D et al. Cloning and characterization of an extracellular Ca(2+)-sensing receptor from bovine parathyroid. Nature 1993; 366: 575-580
14. van Abel M, Hoenderop JG, Bindels RJ. The epithelial calcium channels TRPV5 and TRPV6: Regulation and implications for disease. Naunyn Schmiedebergs Arch Pharmacol 2005; 371: 295-306
15. 2+ channel in 1, 25-dihydroxyvitamin D3-responsive epithelia. J Biol Chem 1999; 274: 8375 8378
16. 2+ hyperabsorption in TRPV5 knockout mice. J Am Soc Nephrol 2005; 16: 3188-3195
17. Hoenderop JG, Muller D, van der Kemp AW et al. Calcitriol controls the epithelial calcium channel in kidney. J Am Soc Nephrol 2001; 12: 1342-1349
18. 2+ and 1,25-dihydroxyvitamin D3 in 25-hydroxyvitamin D3-1alpha-hydroxylase knockout mice. FASEB J 2002; 16: 1398-1406
19. van Abel M, Hoenderop JG, Dardenne O et al. 1,25-dihydroxyvitamin D(3)-independent stimulatory effect of estrogen on the expression of ECaC1 in the kidney. J Am Soc Nephrol 2002; 13: 2102-2109
20. 2+ channels TRPV5 and TRPV6 to the plasma membrane. Mol Cell Biol 2006; 26: 303-312
21. Lambers TT, Weidema AF, Nilius B, Hoenderop JG, Bindels RJ. Regulation of the mouse epithelial Ca(2+) channel TRPV6 by the Ca(2+)-sensor calmodulin. J Biol Chem 2004; 279: 28855-28861
22. Chang Q, Gyftogianni E, van de Graaf SF et al. Molecular determinants in TRPV5 channel assembly. J Biol Chem 2004; 279: 54304-54311
23. Yoshida T, Fujimori T, Nabeshima Y. Mediation of unusually high concentrations of 1,25-dihydroxyvitamin D in homozygous klotho mutant mice by increased expression of renal 1alpha-hydroxylase gene. Endocrinology 2002; 143: 683-689
24. Kuro-o M, Matsumura Y, Aizawa H et al. Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 1997; 390: 45-51
25. Kawano K, Ogata N, Chiano M et al. Klotho gene polymorphisms associated with bone density of aged postmenopausal women. J Bone Miner Res 2002; 17: 1744-1751
26. Arking DE, Atzmon G, Arking A, Barzilai N, Dietz HC. Association between a functional variant of the KLOTHO gene and high-density lipoprotein cholesterol, blood pressure, stroke, and longevity. Circ Res 2005; 96: 412-418