In vitro and in vivo assessment of linezolid combined with ertapenem: A highly synergistic combination against methicillin-resistant Staphylococcus aureus

Antimicrobial Agents and Chemotherapy

Volumn 50, Issue 7, 2006, Pages 2547-2549

  Jacqueline, Cedric ^a   Caillon, Jocelyne ^a   Grossi, Olivier ^a   Le Mabecque, Virginie ^a   Miegeville, Anne Françoise ^a   Bugnon, Denis ^a   Batard, Eric ^a   Potel, Gilles ^a  

^a UNIVERSITÉ DE NANTES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ERTAPENEM; LINEZOLID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL ENDOCARDITIS; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG HALF LIFE; DRUG POTENTIATION; HUMAN; IN VITRO STUDY; IN VIVO STUDY; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; RABBIT;

ACETAMIDES; ANIMALS; ANTI-INFECTIVE AGENTS; BETA-LACTAMS; DRUG SYNERGISM; ENDOCARDITIS, BACTERIAL; HUMANS; METHICILLIN RESISTANCE; OXAZOLIDINONES; RABBITS; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS;

EID: 33745618721     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.01501-05     Document Type: Article

References (19)

1. Amsterdam, D. 1996. Susceptibility testing of antibiotics in liquid media, p. 52-111. In V. Lorian (ed.), Antibiotics in laboratory medicine. Williams & Wilkins Co., Baltimore, Md.
2. Bugnon, D., G. Potel, J. Caillon, D. Baron, H. B. Drugeon, P. Feigel, and M. F. Kergueris. 1998. In vivo simulation of human pharmacokinetics in the rabbit. Bull. Math. Biol. 60:545-567.
3. Chiang, F. Y., and M. Climo. 2003. Efficacy of linezolid alone or in combination with vancomycin for treatment of experimental endocarditis due to methicillin-resistant Staphylococcus aureus. Antimicrob. Agents Chemother. 47:3002-3004.
4. Dailey, C. F., P. J. Pagano, L. V. Buchanan, J. A. Paquette, J. V. Haas, and J. K. Gibson. 2003. Efficacy of linezolid plus rifampin in an experimental model of methicillin-susceptible Staphylococcus aureus endocarditis. Antimicrob. Agents Chemother. 47:2655-2658.
5. Drugeon, H. B., J. Caillon, M. E. Juvin, and J. L. Pirault. 1987. Dynamics of ceftazidime-pefloxacin interaction shown by a new killing curve-checker-board method. J. Antimicrob. Chemother. 19:197-203.
6. Durack, D. T., and P. B. Beeson. 1972. Experimental bacterial endocarditis. II. Survival of bacteria in endocardial vegetations. Br. J. Exp. Pathol. 53:50-53.
7. Garrod, L. P., and P. M. Waterworth. 1962. Methods of testing combined antibiotic bactericidal action and the significance of the results. J. Clin. Pathol. 15:328-338.
8. Jacqueline, C., D. Navas, E. Batard, A. F. Miegeville, V. Le Mabecque, M. F. Kergueris, D. Bugnon, G. Potel, and J. Caillon. 2005. In vitro and in vivo synergistic activities of linezolid combined with subinhibitory concentrations of imipenem against methicillin-resistant Staphylococcus aureus. Antimicrob. Agents Chemother. 49:45-51.
9. Jacqueline, C., E. Batard, L. Perez, D. Boutoille, A. Hamel, J. Caillon, M. F. Kergueris, G. Potel, and D. Bugnon. 2002. In vivo efficacy of continuous infusion versus intermittent dosing of linezolid compared to vancomycin in a methicillin-resistant Staphylococcus aureus rabbit endocarditis model. Antimicrob. Agents Chemother. 46:3706-3711.
10. Jacqueline, C., N. Asseray, E. Batard, V. Le Mabecque, M. F. Kergueris, L. Dube, D. Bugnon, G. Potel, and J. Caillon. 2004. In vivo efficacy of linezolid combined with gentamicin for treatment of experimental endocarditis due to methicillin-resistant Staphylococcus aureus. Int. J. Antimicrob. Agents 24:393-396.
11. Musson, D. G., A. Majumdar, S. Holland, K. Birk, L. Xi, G. Mistry, et al. 2004. Pharmacokinetics of total and unbound ertapenem in healthy elderly subjects. Antimicrob. Agents Chemother. 48:521-524.
12. Musson, D. G., K. L. Birk, A. M. Cairns, A. K. Majumdar, and J. D. Rogers. 1998. High performance liquid chromatographic methods for the determination of a new carbapenem antibiotic, L-749345, in human plasma and urine. J. Chromatogr. B 720:99-106.
13. National Committee for Clinical Laboratory Standards. 1997. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically, 4th ed. Approved standard M7-A4. National Committee for Clinical Laboratory Standards, Wayne, Pa.
14. Pearson, R. D., R. T. Steigbigel, H. T. Davis, and S. W. Chapmann. 1980. Method for reliable determination of minimal lethal antibiotic concentrations. Antimicrob. Agents Chemother. 18:699-708.
15. Peng, G. W., R. P. Stryd, S. Murata, M. Igarashi, K. Chiba, H. Aoyama, M. Aoyama, T. Zenki, and N. Ozawa. 1999. Determination of linezolid in plasma by reversed-phase high-performance liquid chromatography. J. Pharm. Biomed. Anal. 20:65-73.
16. Perlman, B. B., and L. R. Freedman. 1971. Experimental endocarditis. II. Staphylococcal infection of the aortic valve following placement of a polyethylene catheter in the left side of the heart. Yale J. Biol. Med. 44:206-213.
17. Rucker, R. W., and G. M. Garrison. 1974. Outpatient intravenous medications in the management of cystic fibrosis. Pediatrics 54:358-360.
18. Tice, A. D., S. J. Rehm, J. R. Dalovisio, J. S. Bradley, L. P. Martinelli, D. R. Graham, R. B. Gainer, et al. 2004. Practice guidelines for outpatient parenteral antimicrobial therapy. Clin. Infect. Dis. 38:1651-1672.
19. Zhanel, G. G., C. Johanson, J. M. Embil, A. Noreddin, A. Gin, L. Vercaigne, and D. J. Hoban. 2005. Ertapenem: review of a new carbapenem. Expert Rev. Anti. Infect. Ther. 3:23-39.