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Volumn 85, Issue 7, 2006, Pages 861-868

Polycystic ovary syndrome and metformin in pregnancy

Author keywords

Metformin therapy; Polycystic ovary syndrome; Pregnancy

Indexed keywords

CLOMIFENE; INSULIN; METFORMIN; PLACEBO; SULFONYLUREA;

EID: 33745610746     PISSN: 00016349     EISSN: 16000412     Source Type: Journal    
DOI: 10.1080/00016340600780441     Document Type: Article
Times cited : (12)

References (47)
  • 1
    • 0346725827 scopus 로고    scopus 로고
    • Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome
    • The Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril 2004;81:19-25.
    • (2004) Fertil Steril , vol.81 , pp. 19-25
  • 2
    • 0346186090 scopus 로고    scopus 로고
    • Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS)
    • The Rotterdam ESHRE/ASRM-sponsored PCOS consensus workshop group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod 2004;19:41-7.
    • (2004) Hum Reprod , vol.19 , pp. 41-47
  • 3
    • 0032147171 scopus 로고    scopus 로고
    • Polycystic ovarian syndrome: The metabolic syndrome comes to gynecology
    • Hopkinson Z, Sattar N, Fleming R, Greer I. Polycystic ovarian syndrome: the metabolic syndrome comes to gynecology. BMJ. 1998;317:329-32.
    • (1998) BMJ , vol.317 , pp. 329-332
    • Hopkinson, Z.1    Sattar, N.2    Fleming, R.3    Greer, I.4
  • 4
    • 33745603113 scopus 로고    scopus 로고
    • Department of Clinical Science, Division of Obstetrics and Gynaecology, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden
    • Fridström M. Endocrine and therapeutic aspects of infertile women with the polycystic ovary syndrome. Department of Clinical Science, Division of Obstetrics and Gynaecology, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden, 1998.
    • (1998) Endocrine and Therapeutic Aspects of Infertile Women with the Polycystic Ovary Syndrome
    • Fridström, M.1
  • 5
    • 1242308975 scopus 로고    scopus 로고
    • Polycystic ovary syndrome
    • Guzick DS. Polycystic ovary syndrome. Obstet Gynecol. 2004;103:181-93.
    • (2004) Obstet Gynecol , vol.103 , pp. 181-193
    • Guzick, D.S.1
  • 6
    • 0031456016 scopus 로고    scopus 로고
    • Insulin resistance and the polycystic ovary syndrome: Mechanism and implications for pathogenesis
    • Dunaif A. Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis. Endocr Rev. 1997;18:774-800.
    • (1997) Endocr Rev , vol.18 , pp. 774-800
    • Dunaif, A.1
  • 7
    • 0642272536 scopus 로고    scopus 로고
    • Polycystic ovary syndrome in Adolescence
    • Driscoll DA. Polycystic ovary syndrome in Adolescence. Ann N Y Acad Sci. 2003;997:49-55.
    • (2003) Ann N Y Acad Sci , vol.997 , pp. 49-55
    • Driscoll, D.A.1
  • 8
    • 0141923627 scopus 로고    scopus 로고
    • Ultrasound diagnosis of polycystic ovaries in women who have no symptoms of polycystic ovary syndrome is not associated with subfecundity or subfertility
    • Hassan M, Killick S. Ultrasound diagnosis of polycystic ovaries in women who have no symptoms of polycystic ovary syndrome is not associated with subfecundity or subfertility. Fertil Steril. 2003;80:966-75.
    • (2003) Fertil Steril , vol.80 , pp. 966-975
    • Hassan, M.1    Killick, S.2
  • 12
    • 0029095150 scopus 로고
    • Polycystic ovary syndrome
    • Franks S. Polycystic ovary syndrome. N Engl J Med. 1995; 333:853-61.
    • (1995) N Engl J Med , vol.333 , pp. 853-861
    • Franks, S.1
  • 13
    • 0036764004 scopus 로고    scopus 로고
    • Polycystic ovarian syndrome and insulin resistance
    • McFarlane KJ, Isé C, Linton C. Polycystic ovarian syndrome and insulin resistance. Endocrinology. 2002;4:623-6.
    • (2002) Endocrinology , vol.4 , pp. 623-626
    • McFarlane, K.J.1    Isé, C.2    Linton, C.3
  • 15
    • 0038392806 scopus 로고    scopus 로고
    • Descriptive review of the evidence for the use of metformin in polycystic ovary syndrome
    • Harbone L, Fleming R, Lyall H, Sattar N. Descriptive review of the evidence for the use of metformin in polycystic ovary syndrome. Lancet. 2003;361:1894-901.
    • (2003) Lancet , vol.361 , pp. 1894-1901
    • Harbone, L.1    Fleming, R.2    Lyall, H.3    Sattar, N.4
  • 16
    • 0142247208 scopus 로고    scopus 로고
    • Metformin in polycystic ovary syndrome: Systematic review and meta-analysis
    • Lord JM, Flight IH, Norman RJ. Metformin in polycystic ovary syndrome: systematic review and meta-analysis. BMJ. 2003;327:951-6.
    • (2003) BMJ , vol.327 , pp. 951-956
    • Lord, J.M.1    Flight, I.H.2    Norman, R.J.3
  • 17
    • 11144308902 scopus 로고    scopus 로고
    • Women with polycystic ovary syndrome (PCOS) often undergo protracted treatment with metformin and are disinclined to stop: Indications for a change in licensing arrangements?
    • Muth S, Normann J, Sattar N, Fleming R. Women with polycystic ovary syndrome (PCOS) often undergo protracted treatment with metformin and are disinclined to stop: indications for a change in licensing arrangements? Hum Reprod. 2004;19:2718-20.
    • (2004) Hum Reprod , vol.19 , pp. 2718-2720
    • Muth, S.1    Normann, J.2    Sattar, N.3    Fleming, R.4
  • 20
    • 0033710083 scopus 로고    scopus 로고
    • Endocrine and metabolic effects of metformin versus ethinyl estradiol-cyproterone acetate in obese women with polycystic ovary syndrome: A randomized study
    • Morin-Papunen L, Vauhkonen I, Koivunen R, Ruokonen A, Martikainen H, Tapanainen J. Endocrine and metabolic effects of metformin versus ethinyl estradiol-cyproterone acetate in obese women with polycystic ovary syndrome: a randomized study. J Clin Endocrinol Metab. 2000;85:3161-8.
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 3161-3168
    • Morin-Papunen, L.1    Vauhkonen, I.2    Koivunen, R.3    Ruokonen, A.4    Martikainen, H.5    Tapanainen, J.6
  • 21
    • 0842312978 scopus 로고    scopus 로고
    • Anti-Müllerian hormone serum concentrations in normoovulatory and anovulatory women of reproductive age
    • Laven J, Mulders A, Visser J, Themmen A, De Jong F, Fauser B. Anti-Müllerian hormone serum concentrations in normoovulatory and anovulatory women of reproductive age. J Clin Endocrinol Metab. 2004;89:318-23.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 318-323
    • Laven, J.1    Mulders, A.2    Visser, J.3    Themmen, A.4    De Jong, F.5    Fauser, B.6
  • 22
    • 21644435742 scopus 로고    scopus 로고
    • Serum anti-Müllerian hormone levels remain high until late reproductive age and decrease during metformin therapy in women with polycystic ovary syndrome
    • Piltonen T, Morin-Papunen L, Koivunen R, Perheentupa A, Roukonen A, Tapanainen J. Serum anti-Müllerian hormone levels remain high until late reproductive age and decrease during metformin therapy in women with polycystic ovary syndrome. Hum Reprod. 2005;20:1820-6.
    • (2005) Hum Reprod , vol.20 , pp. 1820-1826
    • Piltonen, T.1    Morin-Papunen, L.2    Koivunen, R.3    Perheentupa, A.4    Roukonen, A.5    Tapanainen, J.6
  • 23
    • 0036153384 scopus 로고    scopus 로고
    • Metformin therapy improves ovulatory rates, cervical scores, and pregnancy rates in clomifen citrate-resistant women with polycystic ovary syndrome
    • Kocak M, Caliskan E, Simsir C, Haberal A. Metformin therapy improves ovulatory rates, cervical scores, and pregnancy rates in clomifen citrate-resistant women with polycystic ovary syndrome. Fertil Steril. 2003;77:101-6.
    • (2003) Fertil Steril , vol.77 , pp. 101-106
    • Kocak, M.1    Caliskan, E.2    Simsir, C.3    Haberal, A.4
  • 24
    • 0036009794 scopus 로고    scopus 로고
    • Pregnancies following use of metformin for ovulation induction in patients with polycystic ovary syndrome
    • Heard MJ, Pierce A, Carson SA, Buster JE. Pregnancies following use of metformin for ovulation induction in patients with polycystic ovary syndrome. Fertil Steril. 2002;77:669-73.
    • (2002) Fertil Steril , vol.77 , pp. 669-673
    • Heard, M.J.1    Pierce, A.2    Carson, S.A.3    Buster, J.E.4
  • 25
    • 0041563930 scopus 로고    scopus 로고
    • Laparoscopic treatment of polycystic ovaries: Is it time to relinquish the procedure?
    • Pirwany I, Tulandi T. Laparoscopic treatment of polycystic ovaries: is it time to relinquish the procedure? Fertil Steril. 2003;80:241-51.
    • (2003) Fertil Steril , vol.80 , pp. 241-251
    • Pirwany, I.1    Tulandi, T.2
  • 26
    • 6344245947 scopus 로고    scopus 로고
    • Metformin administration versus laparoscopic ovarian diathermy in clomiphene citrate-resistant women with polycystic ovary syndrome: A prospective parallel randomized double-blind placebo-controlled trial
    • Palomba S, Orio F, Nardo L, Falbo A, Russo T, Corea D, et al. Metformin administration versus laparoscopic ovarian diathermy in clomiphene citrate-resistant women with polycystic ovary syndrome: a prospective parallel randomized double-blind placebo-controlled trial. J Clin Endocrinol Metab. 2004;89:4801-9.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 4801-4809
    • Palomba, S.1    Orio, F.2    Nardo, L.3    Falbo, A.4    Russo, T.5    Corea, D.6
  • 27
    • 0033179753 scopus 로고    scopus 로고
    • Effects of metformin on gonadotropin-induced ovulation in women with polycystic ovary syndrome
    • De Leo V, la Marca A, Ditto A, Morgante G, Cianci A. Effects of metformin on gonadotropin-induced ovulation in women with polycystic ovary syndrome. Fertil Steril. 1999; 72:282-5.
    • (1999) Fertil Steril , vol.72 , pp. 282-285
    • De Leo, V.1    La Marca, A.2    Ditto, A.3    Morgante, G.4    Cianci, A.5
  • 28
    • 27144485352 scopus 로고    scopus 로고
    • A randomized controlled trial evaluating metformin pretreatment and co-administration in non-obese insulin-resistant women with polycystic ovary syndrome treated with controlled ovarian stimulation plus timed intercourse or intrauterine insemination
    • Palomba S, Falbo A, Orio F, Manguso F, Russo T, Tolino A, et al. A randomized controlled trial evaluating metformin pretreatment and co-administration in non-obese insulin-resistant women with polycystic ovary syndrome treated with controlled ovarian stimulation plus timed intercourse or intrauterine insemination. Hum Reprod. 2005;20:2879-86.
    • (2005) Hum Reprod , vol.20 , pp. 2879-2886
    • Palomba, S.1    Falbo, A.2    Orio, F.3    Manguso, F.4    Russo, T.5    Tolino, A.6
  • 29
    • 0036177496 scopus 로고    scopus 로고
    • Co-administration of metformin during rFSH treatment in patients with clomiphene citrate-resistant polycystic ovarian syndrome: A prospective randomized trial
    • Yarari H, Yildiz B, Demirol A, Zeyneloglu H, Yigit N, Bükülumez O, et al. Co-administration of metformin during rFSH treatment in patients with clomiphene citrate-resistant polycystic ovarian syndrome: a prospective randomized trial. Hum Reprod. 2002;17:289-94.
    • (2002) Hum Reprod , vol.17 , pp. 289-294
    • Yarari, H.1    Yildiz, B.2    Demirol, A.3    Zeyneloglu, H.4    Yigit, N.5    Bükülumez, O.6
  • 30
    • 32944462662 scopus 로고    scopus 로고
    • Laparoscopic "drilling" by diathermy or laser for ovulation induction in anovulatory polycystic ovary syndrome
    • Farquhar C, Vandekerckhove P, Lilford R. Laparoscopic "drilling" by diathermy or laser for ovulation induction in anovulatory polycystic ovary syndrome. Cochrane Database Syst Rev 2005, issue 2.
    • (2005) Cochrane Database Syst Rev , Issue.2
    • Farquhar, C.1    Vandekerckhove, P.2    Lilford, R.3
  • 31
    • 0035145624 scopus 로고    scopus 로고
    • Metformin increases the ovulatory rate and pregnancy rate from clomiphene citrate in patients with polycystic ovary syndrome who are resistant to clomiphene citrate alone
    • Vandermolen DT, Ratts VS, Evans WS, Stovall DW, Kauma SW, Nestler JE. Metformin increases the ovulatory rate and pregnancy rate from clomiphene citrate in patients with polycystic ovary syndrome who are resistant to clomiphene citrate alone. Fertil Steril. 2001;75:310-5.
    • (2001) Fertil Steril , vol.75 , pp. 310-315
    • Vandermolen, D.T.1    Ratts, V.S.2    Evans, W.S.3    Stovall, D.W.4    Kauma, S.W.5    Nestler, J.E.6
  • 32
    • 3042634808 scopus 로고    scopus 로고
    • Metformin treatment before IVF/ICSI in women with polycystic ovary syndrome; a prospective, randomized, double blind study
    • Kjøtrod S, von Düring V, Carlsen S. Metformin treatment before IVF/ICSI in women with polycystic ovary syndrome; a prospective, randomized, double blind study. Hum Reprod. 2004;19:1315-22.
    • (2004) Hum Reprod , vol.19 , pp. 1315-1322
    • Kjøtrod, S.1    Von Düring, V.2    Carlsen, S.3
  • 33
    • 23044513823 scopus 로고    scopus 로고
    • Prospective parallel randomized, double-blind, double-dummy controlled clinical trial comparing clomiphene citrate and metformin as the first-line treatment for ovulation induction in nonobese anovulatory women with polycystic ovary syndrome
    • Palomba S, Orio F, Falbo A, Manguso F, Russo T, Cascella T, et al. Prospective parallel randomized, double-blind, double-dummy controlled clinical trial comparing clomiphene citrate and metformin as the first-line treatment for ovulation induction in nonobese anovulatory women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2005; 90:4068-74.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 4068-4074
    • Palomba, S.1    Orio, F.2    Falbo, A.3    Manguso, F.4    Russo, T.5    Cascella, T.6
  • 36
    • 0035168622 scopus 로고    scopus 로고
    • Continuing metformin throughout pregnancy in women with polycystic ovary syndrome appears to safely reduce first-trimester spontaneous abortion: A pilot study
    • Glueck CJ, Phillips H, Cameron D, Wang P, Sieve-Smith L. Continuing metformin throughout pregnancy in women with polycystic ovary syndrome appears to safely reduce first-trimester spontaneous abortion: a pilot study. Fertil Steril. 2001;75:46-52.
    • (2001) Fertil Steril , vol.75 , pp. 46-52
    • Glueck, C.J.1    Phillips, H.2    Cameron, D.3    Wang, P.4    Sieve-Smith, L.5
  • 37
    • 0036851165 scopus 로고    scopus 로고
    • Pregnancy outcomes among women with polycystic ovary syndrome treated with metformin
    • Glueck CJ, Wang P, Goldenberg N, Sieve-Smith L. Pregnancy outcomes among women with polycystic ovary syndrome treated with metformin. Hum Reprod. 2002;17:2858-64.
    • (2002) Hum Reprod , vol.17 , pp. 2858-2864
    • Glueck, C.J.1    Wang, P.2    Goldenberg, N.3    Sieve-Smith, L.4
  • 38
    • 0036181614 scopus 로고    scopus 로고
    • Metformin therapy throughout pregnancy reduces the development of gestational diabetes in women with polycystic ovary syndrome
    • Glueck CJ, Phillips H, Wang P, Sieve-Smith L, Kobayashi S. Metformin therapy throughout pregnancy reduces the development of gestational diabetes in women with polycystic ovary syndrome. Fertil Steril. 2002;77:520-5.
    • (2002) Fertil Steril , vol.77 , pp. 520-525
    • Glueck, C.J.1    Phillips, H.2    Wang, P.3    Sieve-Smith, L.4    Kobayashi, S.5
  • 40
    • 0032937279 scopus 로고    scopus 로고
    • Metformin-induced resumption of normal menses in 39 of 43 (91%) previously amenorrheic women with the polycystic ovary syndrome
    • Glueck CJ, Wang P, Fontaine R, Tracy T, Sieve-Smith L. Metformin-induced resumption of normal menses in 39 of 43 (91%) previously amenorrheic women with the polycystic ovary syndrome. Metabolism. 1999;48:511-9.
    • (1999) Metabolism , vol.48 , pp. 511-519
    • Glueck, C.J.1    Wang, P.2    Fontaine, R.3    Tracy, T.4    Sieve-Smith, L.5
  • 41
    • 0035044332 scopus 로고    scopus 로고
    • Insulin reduction with metformin increases luteal phase serum glycodelin and insulin-like growth factor-binding protein-1 concentrations and enhances uterine vascularity and blood flow in the polycystic ovary syndrome
    • Jakubowics DJ, Seppälä M, Jakubowicz S, Rodriguez-Armas O, Rivas-Santiago A, Koistinen H, et al. Insulin reduction with metformin increases luteal phase serum glycodelin and insulin-like growth factor-binding protein-1 concentrations and enhances uterine vascularity and blood flow in the polycystic ovary syndrome. J Clin Endocrinol Metab. 2001; 86:1126-33.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 1126-1133
    • Jakubowics, D.J.1    Seppälä, M.2    Jakubowicz, S.3    Rodriguez-Armas, O.4    Rivas-Santiago, A.5    Koistinen, H.6
  • 42
    • 1442278770 scopus 로고    scopus 로고
    • Reduced serum glycodelin and insulin-like growth factor-binding protein-1 in women with polycystic ovary syndrome during first trimester of pregnancy
    • Jakubowics DJ, Essah PA, Seppälä M, Jakubowicz S, Baillargeon J-P, Koistinen H, et al. Reduced serum glycodelin and insulin-like growth factor-binding protein-1 in women with polycystic ovary syndrome during first trimester of pregnancy. J Clin Endocrinol Metab. 2004;89:833-9.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 833-839
    • Jakubowics, D.J.1    Essah, P.A.2    Seppälä, M.3    Jakubowicz, S.4    Baillargeon, J.-P.5    Koistinen, H.6
  • 43
    • 0035112663 scopus 로고    scopus 로고
    • Metformin treatment of patients with polycystic ovary syndrome undergoing in vitro fertilization improves outcomes and is associated with modulation of the insulin-like growth factors
    • Stadtmauer LA, Toma SK, Riehl RM, Talbert LM. Metformin treatment of patients with polycystic ovary syndrome undergoing in vitro fertilization improves outcomes and is associated with modulation of the insulin-like growth factors. Fertil Steril. 2001;75:505-9.
    • (2001) Fertil Steril , vol.75 , pp. 505-509
    • Stadtmauer, L.A.1    Toma, S.K.2    Riehl, R.M.3    Talbert, L.M.4
  • 44
    • 4344651482 scopus 로고    scopus 로고
    • Metformin reduces pregnancy complications without affecting androgen levels in pregnant polycystic ovary syndrome women: Results of a randomized study
    • Vanky E, Salvesen K, Heimstad R, Fougner K, Romundstad P, Carlsen S. Metformin reduces pregnancy complications without affecting androgen levels in pregnant polycystic ovary syndrome women: results of a randomized study. Hum Reprod. 2004;19:1734-40.
    • (2004) Hum Reprod , vol.19 , pp. 1734-1740
    • Vanky, E.1    Salvesen, K.2    Heimstad, R.3    Fougner, K.4    Romundstad, P.5    Carlsen, S.6
  • 45
    • 0034977315 scopus 로고    scopus 로고
    • Metabolic and steriodogenic alternations related to increased frequency of polycystic ovaries in women with a history of gestational diabetes
    • Koivunen R, Juutinen J, Vauhkonen I, Morin-Papunen L, Ruokonen A, Tapanainen J. Metabolic and steriodogenic alternations related to increased frequency of polycystic ovaries in women with a history of gestational diabetes. J Clin Endocrinol Metab. 2001;86:2591-9.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 2591-2599
    • Koivunen, R.1    Juutinen, J.2    Vauhkonen, I.3    Morin-Papunen, L.4    Ruokonen, A.5    Tapanainen, J.6
  • 46
    • 0033848295 scopus 로고    scopus 로고
    • Oral hypoglycemic agents in 118 diabetic pregnancies
    • Hellmuth E, Damm P, Molsted-Pedersen L. Oral hypoglycemic agents in 118 diabetic pregnancies. Diabet Med. 2000; 17:507-11.
    • (2000) Diabet Med , vol.17 , pp. 507-511
    • Hellmuth, E.1    Damm, P.2    Molsted-Pedersen, L.3
  • 47
    • 3042685726 scopus 로고    scopus 로고
    • Height, weight, and motor-social development during the first 18 months of life in 126 infants born to 109 mothers with polycystic ovary syndrome who conceived on and continued metformin through pregnancy
    • Glueck C, Goldenberg N, Pranikoff J, Loftspring M, Sieve L, Wang P. Height, weight, and motor-social development during the first 18 months of life in 126 infants born to 109 mothers with polycystic ovary syndrome who conceived on and continued metformin through pregnancy. Hum Reprod. 2004;19:1323-30.
    • (2004) Hum Reprod , vol.19 , pp. 1323-1330
    • Glueck, C.1    Goldenberg, N.2    Pranikoff, J.3    Loftspring, M.4    Sieve, L.5    Wang, P.6


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