메뉴 건너뛰기




Volumn 7, Issue SUPPL. 1, 2006, Pages

Protein engineering: Security implications. The increasing ability to manipulate protein toxins for hostile purposes has prompted calls for regulation

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRAX TOXIN; BACTERIAL TOXIN; BOTULINUM TOXIN; CELL SURFACE PROTEIN; HYBRID PROTEIN; IMMUNOTOXIN; NATURAL PRODUCT; PROTEIN TOXIN; RICIN; SARIN; SAXITOXIN; STAPHYLOCOCCUS ENTEROTOXIN B; SUPERANTIGEN; UNCLASSIFIED DRUG;

EID: 33745605537     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.1038/sj.embor.7400677     Document Type: Article
Times cited : (6)

References (25)
  • 1
    • 0027973442 scopus 로고
    • Cytotoxic effects of a chimeric protein consisting of tetanus toxin light chain and anthrax toxin lethal factor in non-neuronal cells
    • Arora N, Williamson LC, Leppla SH, Halpern JL (1994) Cytotoxic effects of a chimeric protein consisting of tetanus toxin light chain and anthrax toxin lethal factor in non-neuronal cells. J Biol Chem 269: 26165-26171
    • (1994) J Biol Chem , vol.269 , pp. 26165-26171
    • Arora, N.1    Williamson, L.C.2    Leppla, S.H.3    Halpern, J.L.4
  • 2
    • 0002701335 scopus 로고
    • Benefits and threats of developments in biotechnology and genetic engineering
    • Oxford, UK: Oxford University Press
    • Bartfai T, Lundin SJ, Rybeck B (1993) Benefits and threats of developments in biotechnology and genetic engineering. In SIPRI Yearbook 1993: World Armaments and Disarmament, pp 293-305. Oxford, UK: Oxford University Press
    • (1993) SIPRI Yearbook 1993: World Armaments and Disarmament , pp. 293-305
    • Bartfai, T.1    Lundin, S.J.2    Rybeck, B.3
  • 3
    • 0037085473 scopus 로고    scopus 로고
    • The binary Clostridium botulinum C2 toxin as a protein delivery system: Identification of the minimal protein region necessary for interaction of toxin components
    • Barth H, Roebling R, Fritz M, Aktories K (2002) The binary Clostridium botulinum C2 toxin as a protein delivery system: Identification of the minimal protein region necessary for interaction of toxin components. J Biol Chem 277: 5074-5081
    • (2002) J Biol Chem , vol.277 , pp. 5074-5081
    • Barth, H.1    Roebling, R.2    Fritz, M.3    Aktories, K.4
  • 5
    • 33745614475 scopus 로고
    • Convention on the Prohibition of the Development, Production and Stockpiling of Bacteriological (Biological) and Toxin Weapons and on Their Destruction
    • BTWC Washington, DC, USA: Biological and Toxin Weapons Convention
    • BTWC (1972) Convention on the Prohibition of the Development, Production and Stockpiling of Bacteriological (Biological) and Toxin Weapons and on Their Destruction. Washington, DC, USA: Biological and Toxin Weapons Convention
    • (1972)
  • 6
    • 0024784407 scopus 로고
    • Direct expression in E. coli of a functionally active protein A-snake toxin fusion protein
    • Ducancel F, Boulain JC, Trémeau O, Ménez A (1989) Direct expression in E. coli of a functionally active protein A-snake toxin fusion protein. Protein Eng 3: 139-143
    • (1989) Protein Eng , vol.3 , pp. 139-143
    • Ducancel, F.1    Boulain, J.C.2    Trémeau, O.3    Ménez, A.4
  • 7
    • 0034808904 scopus 로고    scopus 로고
    • Interleukin-2 fusion toxin: Targeted therapy for cutaneous T cell lymphoma
    • Foss FM (2001) Interleukin-2 fusion toxin: Targeted therapy for cutaneous T cell lymphoma. Ann NY Acad Sci 941: 166-176
    • (2001) Ann NY Acad Sci , vol.941 , pp. 166-176
    • Foss, F.M.1
  • 8
    • 16844382461 scopus 로고    scopus 로고
    • New considerations in infectious disease outbreaks: The threat of genetically modified microbes
    • Gilsdorf JR, Zilinskas RA (2005) New considerations in infectious disease outbreaks: The threat of genetically modified microbes. Clin Infect Dis 40: 1160-1165
    • (2005) Clin Infect Dis , vol.40 , pp. 1160-1165
    • Gilsdorf, J.R.1    Zilinskas, R.A.2
  • 9
    • 0040669947 scopus 로고    scopus 로고
    • Biological toxins: A bioweapon threat in the 21st century
    • Gorka S, Sullivan R (2002) Biological toxins: A bioweapon threat in the 21st century. Secur Dialogue 33: 141-156
    • (2002) Secur Dialogue , vol.33 , pp. 141-156
    • Gorka, S.1    Sullivan, R.2
  • 10
    • 19944405587 scopus 로고    scopus 로고
    • Toxins: The emerging threat
    • www.asanltr.com/ASANews-98/Toxin.html
    • Hamilton MG (1998) Toxins: The emerging threat. ASA Newsl 98 www.asanltr.com/ASANews-98/Toxin.html
    • (1998) ASA Newsl , pp. 98
    • Hamilton, M.G.1
  • 11
    • 0025906530 scopus 로고
    • Protein engineering of diphtheria-toxin-related interleukin-2 fusion toxins to increase cytotoxic potency for high-affinity IL-2-receptor-bearing target cells
    • Kiyokawa T, Williams DP, Snider CE, Strom TB, Murphy JR (1991) Protein engineering of diphtheria-toxin-related interleukin-2 fusion toxins to increase cytotoxic potency for high-affinity IL-2-receptor-bearing target cells. Protein Eng 4: 463-468
    • (1991) Protein Eng , vol.4 , pp. 463-468
    • Kiyokawa, T.1    Williams, D.P.2    Snider, C.E.3    Strom, T.B.4    Murphy, J.R.5
  • 12
    • 0027370384 scopus 로고
    • Superantigens and their potential role in human disease
    • Kotzin BL, Leung DY, Kappler J, Marrack P (1993) Superantigens and their potential role in human disease. Adv Immunol 54: 99-166
    • (1993) Adv Immunol , vol.54 , pp. 99-166
    • Kotzin, B.L.1    Leung, D.Y.2    Kappler, J.3    Marrack, P.4
  • 13
    • 0034821591 scopus 로고    scopus 로고
    • Chimeric fusion proteins - Pseudomonas exotoxin-based
    • Kreitman RJ (2001) Chimeric fusion proteins - Pseudomonas exotoxin-based. Curr Opin Investig Drugs 2: 1282-1293
    • (2001) Curr Opin Investig Drugs , vol.2 , pp. 1282-1293
    • Kreitman, R.J.1
  • 15
    • 0034838167 scopus 로고    scopus 로고
    • Toxins as weapons of mass destruction. A comparison and contrast with biological-warfare and chemical-warfare agents
    • Madsen JM (2001) Toxins as weapons of mass destruction. A comparison and contrast with biological-warfare and chemical-warfare agents. Clin Lab Med 21: 593-605
    • (2001) Clin Lab Med , vol.21 , pp. 593-605
    • Madsen, J.M.1
  • 16
    • 33745610602 scopus 로고    scopus 로고
    • The US biological weapons program
    • Wheelis M, Rózsa L, Dando M (eds) Cambridge, MA, USA: Harvard University Press
    • Moon JE (2006) The US biological weapons program. In Wheelis M, Rózsa L, Dando M (eds) Deadly Cultures: Biological Weapons Since 1945, pp 9-46. Cambridge, MA, USA: Harvard University Press
    • (2006) Deadly Cultures: Biological Weapons Since 1945 , pp. 9-46
    • Moon, J.E.1
  • 17
    • 18044377806 scopus 로고
    • Convention on the Prohibition of the Development, Production, Stockpiling and Use of Chemical Weapons and on Their Destruction
    • OPCW The Hague, the Netherlands: Organisation for the Prohibition of Chemical Weapons
    • OPCW (1993) Convention on the Prohibition of the Development, Production, Stockpiling and Use of Chemical Weapons and on Their Destruction. The Hague, the Netherlands: Organisation for the Prohibition of Chemical Weapons
    • (1993)
  • 18
    • 33644968059 scopus 로고    scopus 로고
    • Biological threat characterization research: A critical component of national biodefense
    • Petro JB, Carus WS (2005) Biological threat characterization research: A critical component of national biodefense. Biosecur Bioterror 3: 295-308
    • (2005) Biosecur Bioterror , vol.3 , pp. 295-308
    • Petro, J.B.1    Carus, W.S.2
  • 19
    • 14844358296 scopus 로고    scopus 로고
    • Using modified bacterial toxins to deliver vaccine antigens
    • Shaw CA, Starnbach MN (2003) Using modified bacterial toxins to deliver vaccine antigens. ASM News 69: 384-389
    • (2003) ASM News , vol.69 , pp. 384-389
    • Shaw, C.A.1    Starnbach, M.N.2
  • 20
    • 17144388609 scopus 로고    scopus 로고
    • Bioactive IL7-diphtheria fusion toxin secreted by mammalian cells
    • Shulga-Morskoy S, Rich BE (2005) Bioactive IL7-diphtheria fusion toxin secreted by mammalian cells. Protein Eng Des Sel 18: 25-31
    • (2005) Protein Eng Des Sel , vol.18 , pp. 25-31
    • Shulga-Morskoy, S.1    Rich, B.E.2
  • 21
    • 84937319214 scopus 로고
    • Dilemmas of a dual-use technology: Toxins in medicine and warfare
    • Tucker JB (1994) Dilemmas of a dual-use technology: Toxins in medicine and warfare. Politics Life Sci 13: 51-62
    • (1994) Politics Life Sci , vol.13 , pp. 51-62
    • Tucker, J.B.1
  • 22
    • 0020694602 scopus 로고
    • Protein engineering
    • Ulmer KM (1983) Protein engineering. Science 219: 666-671
    • (1983) Science , vol.219 , pp. 666-671
    • Ulmer, K.M.1
  • 23
    • 0003866334 scopus 로고    scopus 로고
    • United States Army Medical Research Institute of Infectious Diseases 4th edn. Fort Detrick, MD, USA: USAMRIID
    • United States Army Medical Research Institute of Infectious Diseases (2001) Medical Management of Biological Casualties Handbook, 4th edn. Fort Detrick, MD, USA: USAMRIID
    • (2001) Medical Management of Biological Casualties Handbook
  • 24
    • 0034581563 scopus 로고    scopus 로고
    • Fusion protein toxins based on diphtheria toxin: Selective targeting of growth factor receptors of eukaryotic cells
    • vanderSpek JC, Murphy JR (2000) Fusion protein toxins based on diphtheria toxin: Selective targeting of growth factor receptors of eukaryotic cells. Meth Enzymol 327: 239-249
    • (2000) Meth Enzymol , vol.327 , pp. 239-249
    • vanderSpek, J.C.1    Murphy, J.R.2
  • 25
    • 0029050766 scopus 로고
    • Scorpion toxins as natural scaffolds for protein engineering
    • Vita C, Roumestand C, Toma F, Menez A (1995) Scorpion toxins as natural scaffolds for protein engineering. Proc Natl Acad Sci USA 92: 6404-6408
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 6404-6408
    • Vita, C.1    Roumestand, C.2    Toma, F.3    Menez, A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.