Treatment of cyclosporine-induced gingival overgrowth with azithromycin-containing toothpaste

Experimental and Clinical Transplantation

Volumn 4, Issue 1, 2006, Pages 420-424

  Argani, Hassan ^a,d   Pourabbas, Reza ^b   Hassanzadeh, Davood ^b   Masri, Marwan ^c   Rahravi, Hooman ^b  

^a SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c RIZK HOSPITAL   (Lebanon)

^d SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Azithromycin; Cyclosporine; Gingival overgrowth

Indexed keywords

ASCORBIC ACID; AZATHIOPRINE; AZITHROMYCIN; CARBOXYMETHYLCELLULOSE; CREATININE; CYCLOSPORIN A; DODECYL SULFATE SODIUM; MENTHOL; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PLACEBO; PREDNISONE; PROPYLENE GLYCOL; SACCHARIN; TOOTHPASTE; UREA;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DRUG BLOOD LEVEL; DRUG DOSE REGIMEN; DRUG EFFICACY; FEMALE; FOLLOW UP; GINGIVA BLEEDING; GINGIVA HYPERPLASIA; GINGIVA OVERGROWTH; HUMAN; KIDNEY GRAFT REJECTION; KIDNEY TRANSPLANTATION; MALE; MOUTH HYGIENE; PATIENT SATISFACTION; PRESCRIPTION; RANDOMIZED CONTROLLED TRIAL; SCALE UP; STATISTICAL SIGNIFICANCE; SURGICAL PATIENT; TOOTH BRUSHING; TREATMENT OUTCOME; TREATMENT PLANNING; UREA NITROGEN BLOOD LEVEL; VISUAL ANALOG SCALE;

ADULT; AZITHROMYCIN; CYCLOSPORINE; FEMALE; GINGIVAL OVERGROWTH; HUMANS; IMMUNOSUPPRESSIVE AGENTS; KIDNEY TRANSPLANTATION; MALE; MIDDLE AGED; TOOTHPASTE;

EID: 33745594280     PISSN: 13040855     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Pernu HE, Pernu LMH, Knuuttila MLE, Huttunen KRH. Gingival overgrowth among renal transplant recipients and uraemic patients. Nephrol Dial Transplant 1993; 8: 1254-1258
2. Pernu HE, Pernu LM, Huttunen KR, Nieminen PA, Knuuttila ML. Gingival overgrowth among renal transplant recipients related to immunosuppressive medication and possible local background factors. J Periodontol 1992; 63: 548-553
3. Somacarrena ML, Hernandez G, Acero J, Moskow BS. Factors related to the incidence and severity of cyclosporin-induced gingival overgrowth in transplant patients. A longitudinal study. J Periodontol 1994; 65: 671-675
4. Wysocki GP, Gretzinger HA, Laupacis A, Ulan RA, Stiller CR. Fibrous hyperplasia of the gingiva. A side effect of cyclosporin therapy. Oral Surg Oral Med Oral Pathol 1983; 55: 274-278.
5. Chabria D, Weintraub RG, Kilpatrick NM. Mechanisms and management of gingival overgrowth in paediatric transplant recipients: a review. Int J Paediatr Dent 2003; 13: 220-229.
6. Dongari A, McDonnell HT, Langlais RP. Drug-induced gingival over-growth. Oral Surg Oral Med Oral Pathol 1993: 76: 543-548.
7. Deliliers GL, Santoro F, Polli N, Bruno E, Fumagalli L, Risciotti E. Light and electron microscopic study of cyclosporin-induced gingival hyperplasia. J Periodontol 1986: 57: 771-775.
8. Aronoff SC, Laurent C, Jacobs MR. In-vitro activity of erythromycin, roxithromycin and CP 62993 against common paediatric pathogens. J Antimicrob Chemother 1987; 19: 275-276
9. Retsema J, Girard A, Schelkly W, Manousos M, Anderson M, Bright G, et al. Spectrum and mode of action of azithromycin (CP-62,993), a new 15-membered-ring macrolide with improved potency against gram-negative organisms. Antimicrob Agents Chemother 1987; 31: 1939-1947
10. Barry AL, Jones RN, Thornsberry C. In vitro activities of azithromycin (CP 62,993), clarithromycin (A-56268; TE-031), erythromycin, roxithromycin, and clindamycin. Antimicrob Agents Chemother 1988; 32: 752-754
11. Puig JM, Lloveras J, Bosch JM, Munne A, Mir M, Barbosa F, Masramon J. Treatment of gingival hyperplasia secondary to cyclosporine by the new macrolide azithromycin. Transplant Proc 1997; 29: 2379-2380
12. Gomez E, Sanchez-Nunez M, Sanchez JE, Corte C, Aguado S, Portal C, et al. Treatment of cyclosporin-induced gingival hyperplasia with azithromycin. Nephrol Dial Transplant 1997; 12: 2694-2697
13. Nash MM, Zaltzman JS. Efficacy of azithromycin in the treatment of cyclosporine-induced gingival hyperplasia in renal transplant recipients. Transplantation 1998; 65: 1611-1615
14. McDonald PJ, Pruul H. Phagocyte uptake and transport of azithromycin. Eur J Clin Microbiol Infect Dis 1991; 10: 828-833
15. Foulds G, Shepard RM, Johnson RB. The pharmacokinetics of azithromycin in human serum and tissues. J Antimicrob Chemother 1990; 25(suppl A): 73-82
16. Schentag JJ, Ballow CH. Tissue-directed pharmacokinetics. Am J Med 1991; 91: 5S-11S
17. Gladue RP, Bright GM, Isaacson RE, Newborg MF. In vitro and in vivo uptake of azithromycin (CP-62,993) by phagocytic cells: possible mechanism of delivery and release at sites of infection. Antimicrob Agents Chemother 1989; 33: 277-282
18. Takei HH, Carranza FA. Gingival hyperplasia. In: Newmann MG, Takei HH, Carranza FA, eds. Carranzas Clinical Periodontology, 9th ed. Philadelphia, Saunders; 2002, pp 266-267
19. Nyman S, Lindhe J, Rosling B. Periodontal surgery in plaque-infected dentitions. J Clin Periodontol. 1977; 4: 240-249
20. Mesa FL, Osuna A, Aneiros J, Gonzalez-Jaranay M, Bravo J, Junco P, et al. Antibiotic treatment of incipient drug-induced gingival overgrowth in adult renal transplant patients. J Periodontal Res. 2003; 38: 141-146
21. Periti P, Mazzei T, Mini E, Novelli A. Pharmacokinetic drug interactions of macrolides. Clin Pharmacokinet 1992: 23: 106-131
22. Nafar M, Ataie R, Einollahi B, Nematizadeh F, Firoozan A, Poorrezagholi F. A comparison between the efficacy of systemic and local azithromycin therapy in treatment of cyclosporine induced gingival overgrowth in kidney transplant patients. Transplant Proc 2003; 35: 2727-2728
23. Maizumi N, Tamura Y, Kanai H, Tsutsui T. Quantitative comparison of the cytocidal effect of seven macrolide antibiotics on human perioclontal ligament fibroblasts. J Periodont Res 2002; 37: 250-254
24. Kwun WH, Suh BY, Kwun KB. Effect of azithromycin in the treatment of cyclosporine-incluced gingival hyperplasia in renal transplant recipients. Transplant Proc 2003; 35: 311-312