Leishmania infection impairs β1-integrin function and chemokine receptor expression in mononuclear phagocytes

Infection and Immunity

Volumn 74, Issue 7, 2006, Pages 3912-3921

  Pinheiro Jr , Nathanael F ^a   Hermida, Micely D R ^a   Macedo, Mariana P ^a,b   Mengel, José ^a   Bafica, Andre ^a,c   Dos Santos, Washington L C ^a,b  

^a INSTITUTO OSWALDO CRUZ   (Brazil)

^b ESCOLA BAHIANA DE MEDICINA E SAÚDE PÚBLICA   (Brazil)

^c NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA1 INTEGRIN; CD11B ANTIGEN; CELL ADHESION MOLECULE; CHEMOKINE RECEPTOR; COLLAGEN; FIBRONECTIN;

ANIMAL CELL; ARTICLE; CELL ADHESION; CELL KILLING; CELL SUBPOPULATION; EXTRACELLULAR MATRIX; GENE EXPRESSION REGULATION; INFECTION RATE; LEISHMANIASIS; MACROPHAGE ACTIVATION; MONONUCLEAR PHAGOCYTE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHAGOCYTOSIS; PRIORITY JOURNAL; PROMASTIGOTE; PROTOZOAL INFECTION; RECEPTOR AFFINITY; RECEPTOR DOWN REGULATION;

ANIMALS; ANTIGENS, CD29; CELL ADHESION; LEISHMANIA BRAZILIENSIS; LEISHMANIASIS, CUTANEOUS; MACROPHAGES, PERITONEAL; MICE; MICE, INBRED BALB C; RECEPTORS, CHEMOKINE;

EID: 33745592528     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.02103-05     Document Type: Article

References (55)

1. Barral, A., D. Pedral-Sampaio, G. Grimaldi, Jr., H. Momen, D. McMahon-Pratt, A. Ribeiro de Jesus, R. Almeida, R. Badaro, M. Barral-Netto, E. M. Carvalho, et al. 1991. Leishmaniasis in Bahia, Brazil: evidence that Leishmania amazonensis produces a wide spectrum of clinical disease. Am. J. Trop. Med. Hyg. 44:536-546.
2. Belhadj, S., F. Pratlong, N. H. Toumi, K. Kallel, H. Mahjoub, H. Babba, R. Azaiez, J. P. Dedet, and E. Chaker. 2002. Visceral leishmaniasis in Tunisia: result of the isoenzymatic characterization of 65 Leishmania infantum strains. Trans. R. Soc. Trop. Med. Hyg. 96:627-630.
3. Bittencourt, A. L., and M. Barral-Netto. 1995. Leishmaniasis, p. 597-651. In W. Doerr and G. Seifert (ed.), Tropical pathology, 2nd ed., vol. 8. Springer, Berlin, Germany.
4. Brittingham, A., G. Chen, B. S. McGwire, K. P. Chang, and D. M. Mosser. 1999. Interaction of Leishmania gp63 with cellular receptors for fibronectin. Infect. Immun. 67:4477-4484.
5. Brown, D. L., D. R. Phillips, C. H. Damsky, and I. F. Charo. 1989. Synthesis and expression of the fibroblast fibronectin receptor in human monocytes. J. Clin. Investig. 84:366-370.
6. Buates, S., and G. Matlashewski. 2001. General suppression of macrophage gene expression during Leishmania donovani infection. J. Immunol. 166:3416-3422.
7. Campbell, J. J., G. Haraldsen, J. Pan, J. Rottman, S. Qin, P. Ponath, D. P. Andrew, R. Warnke, N. Ruffing, N. Kassam, L. Wu, and E. C. Butcher. 1999. The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells. Nature 400:776-780.
8. Campos-Ponce, M., C. Ponce, E. Ponce, and R. D. Maingon. 2005. Leishmania chagasi/infantum: further investigations on Leishmania tropisms in atypical cutaneous and visceral leishmaniasis foci in Central America. Exp. Parasitol. 109:209-219.
9. Carlos, T. M., and J. M. Harlan. 1994. Leukocyte-endothelial adhesion molecules. Blood 84:2068-2101.
10. Carr, M. W., R. Alon, and T. A. Springer. 1996. The C-C chemokine MCP-I differentially modulates the avidity of beta 1 and beta 2 integrins on T lymphocytes. Immunity 4:179-187.
11. Carvalhal, D. G., A. Barbosa, Jr., M. D'El-Rei Hermida, J. Clarencio, N. F. Pinheiro, Jr., P. S. Veras, and W. L. Dos-Santos. 2004. The modelling of mononuclear phagocyte-connective tissue adhesion in vitro: application to disclose a specific inhibitory effect of Leishmania infection. Exp. Parasitol. 107:189-199.
12. Chvatchko, Y., A. J. Hoogewerf, A. Meyer, S. Alouani, P. Juillard, R. Buser, F. Conquet, A. E. Proudfoot, T. N. Wells, and C. A. Power. 2000. A key role for CC chemokine receptor 4 in lipopolysaccharide-induced endotoxic shock. J. Exp. Med. 191:1755-1764.
13. Colmenares, M., S. Kar, K. Goldsmith-Pestana, and D. McMahon-Pratt. 2002. Mechanisms of pathogenesis: differences amongst Leishmania species. Trans. R. Soc. Trop. Med. Hyg. 96(Suppl. 1):S3-S7.
14. Culling, C. F. A., R. T. Allison, and W. T. Barr. 1985. Cellular pathology technique, 4th ed. Butterworths, London, United Kingdom.
15. Dasgupta, B., K. Roychoudhury, S. Ganguly, M. A. Akbar, P. Das, and S. Roy. 2003. Infection of human mononuclear phagocytes and macrophage-like THP1 cells with Leishmania donovani results in modulation of expression of a subset of chemokines and a chemokine receptor. Scand. J. Immunol. 57:366-374.
16. Davignon, D., E. Martz, T. Reynolds, K. Kurzinger, and T. A. Springer. 1981. Monoclonal antibody to a novel lymphocyte function-associated antigen (LFA-1): mechanism of blockade of T lymphocyte-mediated killing and effects on other T and B lymphocyte functions. J. Immunol. 127:590-595.
17. de Almeida, M. C. 2002. Infective inoculum for Leishmania. Trends Parasitol. 18:154-155.
18. de Almeida, M. C., S. A. Cardoso, and M. Barral-Netto. 2003. Leishmania (Leishmania) chagasi infection alters the expression of cell adhesion and costimulatory molecules on human monocyte and macrophage. Int. J. Parasitol. 33:153-162.
19. de Almeida, M. C., V. Vilhena, A. Barral, and M. Barral-Netto. 2003. Leishmanial infection: analysis of its first steps. A review. Mem. Inst. Oswaldo Cruz 98:861-870.
20. Detmers, P. A., S. K. Lo, E. Olsen-Egbert, A. Walz, M. Baggiolini, and Z. A. Cohn. 1990. Neutrophil-activating protein 1/interleukin 8 stimulates the binding activity of the leukocyte adhesion receptor CD11b/CD18 on human neutrophils. J. Exp. Med. 171:1155-1162.
21. Gradoni, L., and M. Gramiccia. 1994. Leishmania infantum tropism: strain genotype or host immune status? Parasitol. Today 10:264-267.
22. Hogg, N., R. Henderson, B. Leitinger, A. McDowall, J. Porter, and P. Stanley. 2002. Mechanisms contributing to the activity of integrins on leukocytes. Immunol. Rev. 186:164-171.
23. Kakazu, T., J. Chihara, A. Saito, and S. Nakajima. 1995. Effect of RANTES on eosinophil adhesion to plates coated with recombinant soluble intercellular adhesion molecule-1 and expression of beta 2-integrin adhesion molecules on eosinophils. Int. Arch. Allergy Immunol. 108(Suppl. 1):9-11.
24. Katagiri, K., M. Hattori, N. Minato, and T. Kinashi. 2002. Rap1 functions as a key regulator of T-cell and antigen-presenting cell interactions and modulates T-cell responses. Mol. Cell. Biol. 22:1001-1015.
25. Kaye, P. M., N. J. Rogers, A. J. Curry, and J. C. Scott. 1994. Deficient expression of co-stimulatory molecules on Leishmania-infected macrophages. Eur. J. Immunol. 24:2850-2854.
26. Laudanna, C., J. Y. Kim, G. Constantin, and E. Butcher. 2002. Rapid leukocyte integrin activation by chemokines. Immunol. Rev. 186:37-46.
27. Liarte, D. B., I. L. Mendonca, F. C. Luz, E. A. Abreu, G. W. Mello, T. J. Farias, A. F. Ferreira, M. A. Millington, and C. H. Costa. 2001. QBC for the diagnosis of human and canine American visceral leishmaniasis: preliminary data. Rev. Soc. Bras. Med. Trop. 34:577-581.
28. Lira, R., M. Doherty, G. Modi, and D. Sacks. 2000. Evolution of lesion formation, parasitic load, immune response, and reservoir potential in C57BL/6 mice following high- and low-dose challenge with Leishmania major. Infect. Immun. 68:5176-5182.
29. Lloyd, A. R., J. J. Oppenheim, D. J. Kelvin, and D. D. Taub. 1996. Chemokines regulate T cell adherence to recombinant adhesion molecules and extracellular matrix proteins. J. Immunol. 156:932-938.
30. Martinez, J. E., Alba, L. Arias, M. A. Escobar, and N. G. Saravia. 1992. Haemoculture of Leishmania (Viannia) braziliensis from two cases of mucosal leishmaniasis: re-examination of haematogenous dissemination. Trans. R. Soc. Trop. Med. Hyg. 86:392-394.
31. Moll, H., H. Fuchs, C. Blank, and M. Rollinghoff. 1993. Langerhans cells transport Leishmania major from the infected skin to the draining lymph node for presentation to antigen-specific T cells. Eur. J. Immunol. 23:1595-1601.
32. Muraille, E., C. De Trez, B. Pajak, F. A. Torrentera, P. De Baetselier, O. Leo, and Y. Carlier. 2003. Amastigote load and cell surface phenotype of infected cells from lesions and lymph nodes of susceptible and resistant mice infected with Leishmania major. Infect. Immun. 71:2704-2715.
33. Nacy, C. A., and C. L. Diggs. 1981. Intracellular replication of Leishmania tropica in mouse peritoneal macrophages: comparison of amastigote replication in adherent and nonadherent macrophages. Infect. Immun. 34:310-313.
34. Noyes, H., M. Chance, C. Ponce, E. Ponce, and R. Maingon. 1997. Leishmania chagasi: genotypically similar parasites from Honduras cause both visceral and cutaneous leishmaniasis in humans. Exp. Parasitol. 85:264-273.
35. Power, C. A., A. Meyer, K. Nemeth, K. B. Bacon, A. J. Hoogewerf, A. E. Proudfoot, and T. N. Wells. 1995. Molecular cloning and functional expression of a novel CC chemokine receptor cDNA from a human basophilic cell line. J. Biol. Chem. 270:19495-19500.
36. Randolph, G. J., K. Inaba, D. F. Robbiani, R. M. Steinman, and W. A. Muller. 1999. Differentiation of phagocytic monocytes into lymph node dendritic cells in vivo. Immunity 11:753-761.
37. Ritter, U., A. Meissner, C. Scheidig, and H. Korner. 2004. CD8 alpha- and Langerin-negative dendritic cells, but not Langerhans cells, act as principal antigen-presenting cells in leishmaniasis. Eur. J. Immunol. 34:1542-1550.
38. Rosenthal, L. A., F. S. Sutterwala, M. E. Kehrli, and D. M. Mosser. 1996. Leishmania major-human macrophage interactions: cooperation between Mac-1 (CD11b/CD18) and complement receptor type 1 (CD35) in promastigote adhesion. Infect. Immun. 64:2206-2215.
39. Rosso, F., A. Giordano, M. Barbarisi, and A. Barbarisi. 2004. From cell-ECM interactions to tissue engineering. J. Cell. Physiol. 199:174-180.
40. Rozen, S., and H. Skaletsky. 2000. Primer3 on the WWW for general users and for biologist programmers. Methods Mol. Biol. 132:365-386.
41. Saha, B., G. Das, H. Vohra, N. K. Ganguly, and G. C. Mishra. 1995. Macrophage-T cell interaction in experimental visceral leishmaniasis: failure to express costimulatory molecules on Leishmania-infected macrophages and its implication in the suppression of cell-mediated immunity. Eur. J. Immunol. 25:2492-2498.
42. Sato, K., H. Kawasaki, H. Nagayama, R. Serizawa, J. Ikeda, C. Morimoto, K. Yasunaga, N. Yamaji, K. Tadokoro, T. Juji, and T. A. Takahashi. 1999. CC chemokine receptors, CCR-1 and CCR-3, are potentially involved in antigen-presenting cell function of human peripheral blood monocyte-derived dendritic cells. Blood 93:34-42.
43. Sozzani, S., W. Luini, A. Borsatti, N. Polentarutti, D. Zhou, L. Piemonti, G. D'Amico, C. A. Power, T. N. Wells, M. Gobbi, P. Allavena, and A. Mantovani. 1997. Receptor expression and responsiveness of human dendritic cells to a defined set of CC and CXC chemokines. J. Immunol. 159:1993-2000.
44. Steigerwald, M., and H. Moll. 2005. Leishmania major modulates chemokine and chemokine receptor expression by dendritic cells and affects their migratory capacity. Infect. Immun. 73:2564-2567.
45. Takagi, J., and T. A. Springer. 2002. Integrin activation and structural rearrangement. Immunol. Rev. 186:141-163.
46. Tapia, F. J., G. Caceres-Dittmar, M. A. Sanchez, C. T. Fernandez, A. J. Rondon, and J. Convit. 1994. Adhesion molecules in lesions of American cutaneous leishmaniasis. Exp. Dermatol. 3:17-22.
47. Teixeira, M. C., R. de Jesus Santos, R. B. Sampaio, L. Pontes-de-Carvalho, and W. L. dos-Santos. 2002. A simple and reproducible method to obtain large numbers of axenic amastigotes of different Leishmania species. Parasitol. Res. 88:963-968.
48. Verani, A., F. Sironi, A. G. Siccardi, P. Lusso, and D. Vercelli. 2002. Inhibition of CXCR4-tropic HIV-1 infection by lipopolysaccharide: evidence of different mechanisms in macrophages and T lymphocytes. J. Immunol. 168:6388-6395.
49. Weber, C., R. Alon, B. Moser, and T. A. Springer. 1996. Sequential regulation of alpha 4 beta 1 and alpha 5 beta 1 integrin avidity by CC chemokines in monocytes: implications for transendothelial chemotaxis. J. Cell Biol. 134:1063-1073.
50. Wilson, M. E., D. J. Innes, A. D. Sousa, and R. D. Pearson. 1987. Early histopathology of experimental infection with Leishmania donovani in hamsters. J. Parasitol. 73:55-63.
51. Worgall, S., R. Connor, R. J. Kaner, E. Fenamore, K. Sheridan, R. Singh, and R. G. Crystal. 1999. Expression and use of human immunodeficiency virus type 1 coreceptors by human alveolar macrophages. J. Virol. 73:5865-5874.
52. Wright, S. D., P. A. Reddy, M. T. Jong, and B. W. Erickson. 1987. C3bi receptor (complement receptor type 3) recognizes a region of complement protein C3 containing the sequence Arg-Gly-Asp. Proc. Natl. Acad. Sci. USA 84:1965-1968.
53. Wyler, D. J. 1982. In vitro parasite-monocyte interactions in human leishmaniasis. Evidence for an active role of the parasite in attachment. J. Clin. Invest. 70:82-88.
54. Yanagihara, S., E. Komura, J. Nagafune, H. Watarai, and Y. Yamaguchi. 1998. EBI1/CCR7 is a new member of dendritic cell chemokine receptor that is up-regulated upon maturation. J. Immunol. 161:3096-3102.
55. Zhou, Y., T. Kurihara, R. P. Ryseck, Y. Yang, C. Ryan, J. Loy, G. Warr, and R. Bravo. 1998. Impaired macrophage function and enhanced T cell-dependent immune response in mice lacking CCR5, the mouse homologue of the major HIV-1 coreceptor. J. Immunol. 160:4018-4025.