Imaging of lymphatic vessels in breast cancer-related lymphedema: Intradermal versus subcutaneous injection of 99mTc-immunoglobulin

American Journal of Roentgenology

Volumn 186, Issue 5, 2006, Pages 1349-1355

  O'Mahony, Susan ^a   Solanki, Chandra K ^a   Barber, Robert W ^a   Mortimer, Peter S ^b   Purushotham, Arnie D ^a   Peters, A Michael ^a,c  

^a ADDENBROOKE S HOSPITAL   (United Kingdom)

^b ST GEORGE S HOSPITAL   (United Kingdom)

^c ROYAL SUSSEX COUNTY HOSPITAL   (United Kingdom)

Author keywords

99mTc HIG; Breast cancer related lymphedema; Intradermal injection; Lymph nodes; Lymphangiography; Lymphoscintigraphy; Oncologic imaging; Subcutaneous injection

Indexed keywords

AMERTEC II; IMMUNOGLOBULIN G; TECHNETIUM 99M; UNCLASSIFIED DRUG; DIAGNOSTIC AGENT; IMMUNOGLOBULIN; TECHNETIUM; TECHNETIUM TC 99M IMMUNOGLOBULIN;

ADULT; AGED; APPARATUS; ARTICLE; BLOOD SAMPLING; BREAST CANCER; CLINICAL ARTICLE; DIAGNOSTIC ACCURACY; DIAGNOSTIC IMAGING; DIAGNOSTIC VALUE; FEMALE; HUMAN; IMAGE ANALYSIS; IMAGE ENHANCEMENT; INTERMETHOD COMPARISON; LYMPHEDEMA; LYMPHOSCINTIGRAPHY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; BREAST TUMOR; COMPARATIVE STUDY; LYMPH VESSEL; MIDDLE AGED; SCINTISCANNING; SUBCUTANEOUS DRUG ADMINISTRATION;

ADULT; AGED; BREAST NEOPLASMS; FEMALE; HUMANS; IMMUNOGLOBULINS; INJECTIONS, SUBCUTANEOUS; LYMPHATIC VESSELS; LYMPHEDEMA; MIDDLE AGED; TECHNETIUM;

EID: 33745537080     PISSN: 0361803X     EISSN: None     Source Type: Journal    
DOI: 10.2214/AJR.04.1341     Document Type: Article

References (19)

1. Mortimer PS, Bates DO, Brassington HD, Stanton AWB, Strachan DP, Levick JR. The prevalence of arm oedema following treatment for breast cancer. Q J Med 1996; 89:377-380
2. Stanton AWB, Levick JR, Mortimer PS. Current puzzles represented by postmastectomy oedema (breast cancer related lymphoedema). Vasc Med 1996; 1:213-225
3. Pain SJ, Barber RW, Ballinger JR, et al. Transport of radiolabeled immunoglobulin injected into the web spaces of the hands of normal subjects and patients with breast cancer-related lymphedema. J Vasc Res 2004; 41:183-192
4. Pain SJ, Barber RW, Ballinger JR, et al. Local vascular access of radioprotein injected subcutaneously in normal subjects and patients with breast cancer-related lymphedema. J Nucl Med 2004; 45:789-796
5. Pain SJ, Pumshotham AD, Barber RW, et al. Underlying variation in lymphatic function predisposes to development of breast cancer-related lymphoedema. Eur J Surg Oncol 2004; 30:508-514
6. Ohtake E, Matsui K. Lymphoscintigraphy in patients with lymphedema: a new approach using intradermal injections of technetium-99m human serum albumin. Clin Nucl Med 1986; 11:474-478
7. Nawaz K, Hamad M, Sadek S, et al. Lymphoscintigraphy in peripheral lymphedema using technetium-labelled human serum albumin: normal and abnormal patterns. Lymphology 1985; 18:181-186
8. McNeill GC, Witte MH, Witte CL, et al. Whole-body lymphoscintigraphy: preferred method for initial assessment of the peripheral lymphatic system. Radiology 1989; 172:495-502
9. Weissleder H, Weissleder R. Lymphedema: evaluation of qualitative and quantitative lymphoscintigraphy in 238 patients. Radiology 1988; 167:729-735
10. O'Mahony S, Rose SL, Chilvers AJ, et al. Finding an optimal method for imaging lymphatic vessels of the upper limb. Eur J Nucl Med Mol Imaging 2004; 3:555-563
11. Rosse C, Gaddum-Rosse P. Hollinshead's textbook of anatomy, 5th ed. Philadelphia, PA: Lippincott-Raven, 1997
12. Stanton AWB, Kadoo P, Mortimer PS, Levick JR. Quantification of the initial lymphatic network in normal human forearm skin using fluorescence microlymphography and stereological methods. Microvasc Res 1997; 54:156-163
13. Leak LV. Electron microscope observations on lymphatic capillaries and the structural components of the connective tissue-lymph interface. Microvasc Res 1970; 2:361-391
14. O'Mahony S, Ballinger J, Barber R, Rose S, Peters AM, Purushotham AD. Investigation of lymphovenous communications in the upper limb. Eur J Cancer 2003; 1[suppl]:28
15. Casley-Smith JR. Measuring and representing peripheral oedema and its alterations. Lymphology 1994; 27:56-70
16. Pearson TC, Guthrie DL, Simpson J, et al. Interpretation of measured red cell mass and plasma volume in adults: expert panel on radionuclides of the International Council for Standardization in Haematology. Br J Haematol 1995; 89:748-756
17. Pain SJ, Barber RW, Ballinger JR, et al. Side-to-side symmetry of radioprotein transfer from tissue space to systemic vasculature following subcutaneous injection in normal subjects and patients with breast cancer. Eur J Nucl Med Mol Imaging 2003; 30:657-661
18. Parving HH, Jensen HA, Westrup M. Increased transcapillary escape rate of albumin and IgG in essential hypertension. Scand J Clin Lab Invest 1977; 37:223-227
19. Callahan RJ, Barrow SA, Abrams MJ, Rubin RH, Fischman AJ. Biodistribution and dosimetry of technetium-99m-hydrazine nicotinamide IgG: comparison with In-111-DTPA-IgG. J Nucl Med 1996; 37:843-846