Glutathione S-transferase M1 gene polymorphisms are associated with cardiac iron deposition in patients with β-thalassemia major

Hemoglobin

Volumn 30, Issue 2, 2006, Pages 251-256

  Wu, Kang Hsi ^a   Chang, Jan Gowth ^a   Ho, Yung Jen ^a   Wu, Shu Fen ^a   Peng, Ching Tien ^a  

^a CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Thalassemia (thal) major; Glutathione S transferase M1 (GSTM1); Glutathione S transferase T1 (GSTT1); Polymorphism(s)

Indexed keywords

ANTIOXIDANT; GLUTATHIONE TRANSFERASE M1; GLUTATHIONE TRANSFERASE T1;

ADOLESCENT; ADULT; BETA THALASSEMIA; CLINICAL ARTICLE; CONFERENCE PAPER; DIABETES MELLITUS; FEMALE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; GROWTH HORMONE DEFICIENCY; HEART DISEASE; HEART LEFT VENTRICLE EJECTION FRACTION; HUMAN; HYPOGONADISM; HYPOPARATHYROIDISM; INCIDENCE; IRON OVERLOAD; LIVER FUNCTION; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PEROXIDATION; POLYMERASE CHAIN REACTION; PRESCHOOL CHILD; SCHOOL CHILD; SIGNAL PROCESSING; THALASSEMIA MAJOR; TISSUE INJURY;

ADOLESCENT; ADULT; BETA-THALASSEMIA; BLOOD TRANSFUSION; CARDIOMYOPATHIES; CHELATION THERAPY; CHILD; COMBINED MODALITY THERAPY; COMORBIDITY; DEFEROXAMINE; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; GLUTATHIONE TRANSFERASE; HUMANS; IRON; IRON CHELATING AGENTS; IRON OVERLOAD; MALE; OXIDATIVE STRESS; POLYMORPHISM, GENETIC; PYRIDONES; STROKE VOLUME;

EID: 33745515012     PISSN: 03630269     EISSN: 1532432X     Source Type: Journal    
DOI: 10.1080/03630260600642575     Document Type: Conference Paper

References (14)

1. Hershko C, Graham G, Bates GW, Rachmilewitz EA. Non-specific serum iron in thalassaemia: an abnormal serum iron fraction of potential toxicity. Br J Haematol 1978; 40(2):255-263.
2. Halliwell B, Gutteridge JM. Role of free radicals and catalytic metal ions in human disease: an overview. Methods Enzymol 1990; 186:1-85.
3. Doroshow JH, Locker GY, Myers CE. Enzymatic defenses of the mouse heart against reactive oxygen metabolites: alterations produced by doxorubicin. J Clin Invest 1980; 65(1):128-135.
4. Aldouri MA, Wonke B, Hoffbrand AV, Flynn DM, Ward SE, Agnew JE, Hilson AJ. High incidence of cardiomyopathy in β-thalassaemia patients receiving regular transfusion and iron chelation: reversal by intensified chelation. Acta Haematol 1990; 84(3):113-117.
5. Wilce MC, Parker MW. Structure and function of glutathione S-transferases. Biochim Biophys Acta 1994; 1205(1):1-18.
6. Livrea MA, Tesoriere L, Pintaudi AM, Calabrese A, Maggio A, Freisleben HJ, D'Arpa D, D'Anna R, Bongiorno A. Oxidative stress and antioxidant status in β-thalassemia major: iron overload and depletion of lipid-soluble antioxidants. Blood 1996; 88(9):3608-3614.
7. Yang Y, Kao MT, Chang CC, Chung SY, Chen CM, Tsai JJ, Chang JG. Glutathione S-transferase T1 deletion is a risk factor for developing end-stage renal disease in diabetic patients. Int J Mol Med 2004; 14(5):855-859.
8. Wu KH, Chang JS, Su BH, Peng CT. Tricuspid regurgitation in patients with β-thalassemia major. Ann Hematol 2004; 83(12):779-783.
9. Chen CM, Chang JG, Ko YC. Ethnic variation in CYP2E1, GSTM1, GSTT1 genes polymorphism analysis: Taiwan aborigines, Thai and Filipino. Mid Taiwan J Med 2000; 5(3):181-188.
10. Kassab-Chekir A, Laradi S, Ferchichi S, Haj Khelil A, Feki M, Amri F, Selmi H, Bejaoui M, Miled A. Oxidant, antioxidant status and metabolic data in patients with β-thalassemia. Clin Chim Acta 2003; 338(1-2):79-86.
11. Meral A, Tuncel P, Surmen-Gur E, Ozbek R, Ozturk E, Gunay U. Lipid peroxidation and antioxidant status in β-thalassemia. Pediatr Hematol Oncol 2000; 17(8):687-693.
12. Reller K, Dresow B, Collell M, Fischer R, Engelhardt R, Nielsen P, Durken M, Politis C, Piga A. Iron overload and antioxidant status in patients with β-thalassemia major. Ann NY Acad Sci 1998; 850:463-465.
13. Kolnagou A, Fessas C, Papatryphonas A, Economides C, Kontoghiorghes GJ. Prophylactic use of deferiprone (L1) and magnetic resonance imaging T2* or T2 for preventing heart disease in thalassaemia. Br J Haematol 2004; 127(3):360-361.
14. Peng CT, Chow KC, Chen JH, Chiang YP, Lin TY, Tsai CH. Safety monitoring of cardiac and hepatic systems in β-thalassemia patients with chelating treatment in Taiwan. Eur J Haematol 2003; 70(6):392-397.