Pro-apoptotic effect of cecropin AD on nasopharyngeal carcinoma cells

Chinese Medical Journal

Volumn 119, Issue 12, 2006, Pages 1042-1046

  Xiao, Ye Chen ^a   Huang, Ya Dong ^b   Xu, Pei Lin ^a   Zhou, Zhen Qing ^c   Li, Xiao Kun ^d  

^a SUN YAT SEN UNIVERSITY   (China)

^b JINAN UNIVERSITY   (China)

^c MIAMI UNIVERSITY   (United States)

^d WENZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Cecropin AD; CNE2 cells; Nasopharyngeal carcinoma

Indexed keywords

ANTINEOPLASTIC AGENT; CECROPIN A; CECROPIN D; DNA FRAGMENT; HYBRID PROTEIN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL LINE; CELL STRUCTURE; CONTROLLED STUDY; EUKARYOTIC CELL; EXPRESSION VECTOR; FLOW CYTOMETRY; GENE EXPRESSION; GENETIC SCREENING; HUMAN; HUMAN CELL; IN VIVO STUDY; MOLECULAR CLONING; NASOPHARYNX CARCINOMA; NONVIRAL GENE DELIVERY SYSTEM; POLYMERASE CHAIN REACTION; RECOMBINANT PLASMID; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 33745484487     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: 10.1097/00029330-200606020-00014     Document Type: Article

References (10)

1. McDermott AL, Dutt SN, Watkinson JC. The aetiology of nasopharyngeal carcinoma. Clin Otolaryngol 2001; 26: 82-92.
2. Freytag SO, Kim JH, Brown SL, Barton K, Lu M, Chung M. Gene therapy strategies to improve the effectiveness of cancer radiotherapy. Expert Opin Biol Ther 2004; 4: 1757-1770.
3. Stelner HD, Hultmark A, Engstrdom H, Bennich H, Boman HG. Sequence and specificity of two antibacterial proteins involved in insect immunity. Nature 1981; 292: 246-248.
4. Shin SY, Kang JH, Jang SY, Kim SD, Ryu PD, Hahm KS, et al. Effects of the hinge region of cecropin A (1-8)-magainin 2(1-12), a synthetic antimicrobial peptide, on liposomes, bacterial and tumor cells. Biochim Biophys Acta 2000; 1463: 209-218.
5. Utsugi T, Schroit AJ, Connor J, Bucana CD, Fidler IJ. Elevated expression of phosphatidylserine in the outer membrane leaflet of human tumor cells and recognition by activated human blood monocytes. Cancer Res 1991; 51: 3062-3066.
6. Mai JC, Mi Z, Kim SH, Ng B, Robbins PD. A proapoptotic peptide for the treatment of solid tumors. Cancer Res 2001; 61: 7709-7712.
7. Risso A, Braidot E, Sordano MC, VianelloA, Macri F, Skerlavaj B. BMAP-28, an antibiotic peptide of innate immunity, induces cell death through opening of the mitochondrial permeability transition pore. Mol Cell Biol 2002; 22: 1926-1935.
8. Cruciani RA, Barker JL, Zasloff M, Chen HC, Colamonici O. Antibiotic magainins exert cytolytic activity against transformed cell lines through channel formation. Proc Natl Acad Sci U S A 1991; 88: 3792-3796.
9. Christensen B, Fink J, Merrifield RB, Mauzerall D. Channel-forming properties of cecropins and related model compounds incorporated into planar lipid membranes. Proc Natl Acad Sci U S A 1988; 85: 5072-5076.
10. Ling BX, Meng QL, Wang JN, Bao WH, Wu J. Effect of cecropin on cytoskeleton of human nasopharyngeal carcinoma cell line CNE2. J Nanjing Mil Med Coll (Chin) 2003; 25: 1-3.