The prognostic role of gamma-glutamyltransferase for cardiovascular events;Ruolo della gamma-glutamiltransferasi quale fattore di rischio cardiovascolare

Recenti Progressi in Medicina

Volumn 97, Issue 5, 2006, Pages 241-245

  Emdin, Michele ^a   Pompella, Alfonso ^b   Passino, Claudio ^a   Paolicchi, Aldo ^b  

^a CNR   (Italy)

^b UNIVERSITY OF PISA   (Italy)

Author keywords

Atherosclerosis; Cardiovascular risk factors; Gamma glutamyltransferase

Indexed keywords

GAMMA GLUTAMYLTRANSFERASE; GLUTATHIONE;

ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; ENZYME BLOOD LEVEL; HEPATOBILIARY DISEASE; LABORATORY TEST; PATHOGENESIS; PROGNOSIS; PROTEIN DEGRADATION; REVIEW;

ATHEROSCLEROSIS; BIOLOGICAL MARKERS; CARDIOVASCULAR DISEASES; GAMMA-GLUTAMYLTRANSFERASE; HUMANS; PREDICTIVE VALUE OF TESTS; PROGNOSIS; RISK FACTORS;

EID: 33745470960     PISSN: 00341193     EISSN: 00341193     Source Type: Journal    
DOI: None     Document Type: Review

References (23)

1. Whitfield JB. Gamma-glutamyl transferase. Crit Rev Clin Lab Sci 2001; 38: 263-355.
2. Pompella A, Emdin M, Passino C, Paolicchi A. The significance of serum γ-glutamyltransferase in cardiovascular diseases. Clin Chem Lab Med 2004; 42: 1085-91.
3. Emdin M, Passino C, Donato L, Paolicchi A, Pompella A. Serum gamma-glutamyltransferase as a risk factor of ischemic stroke might be independent of alcohol consumption. Stroke 2002; 33: 1163-4.
4. Paolicchi A, Emdin M, Ghliozeni E, Ciancia E, Passino C, Popoff G, Pompella A. Human atherosclerotic plaques contain gamma-glutamyl transpeptidase enzyme activity. Circulation 2004; 109: 1440.
5. Conigrave KM, Saunders JB, Reznik RB, Whitfield JB. Prediction of alcohol-related harm by laboratory test results. Clin Chem 1993; 39: 2266-70.
6. Brenner H, Rothenbacher D, Arndt V, Schuberth S, Fraisse E, Fliedner TM. Distribution, determinants, and prognostic value of gamma-glutamyltranspeptidase for all-cause mortality in a cohort of construction workers from South Germany. Prev Med 1997; 26: 305-10.
7. Jousilahti P, Rastenyte D, Tuomilehto J. Serum gamma-glutamyltransferase, self-reported alcohol drinking, and the risk of stroke. Stroke 2000; 31: 1851-5.
8. Emdin M, Passino C, Michelassi C, Titta F, L'Abbate A, Donato L, Pompella A, Paolicchi A. Prognostic value of serum gamma-glutamyl transferase activity after myocardial infarction. Eur Heart J 2001; 22: 1802-7.
9. Karlson BW, Wiklund O, Hallgren P, Sjolin M, Lindqvist J, Herlitz J. Ten-year mortality amongst patients with a very small or unconfirmed acute myocardial infarction in relation to clinical history, metabolic screening and signs of myocardial ischaemia. J Intern Med 2000; 247: 449-56.
10. Wannamethee G, Ebrahim S, Shaper AG. Gamma-glutamyltransferase: determinants and association with mortality from ischaemic heart disease and all causes. Am J Epidemiol 1995; 142: 699-708.
11. Ruttmann E, Brant LJ, Concin H, Diem G, Rapp K, Hanno Ulmer H. Gamma-glutamyl transferase as a risk factor for cardiovascular disease mortality: an epidemiologic investigation in a cohort of 163,944 austrian adults. Circulation 2005; 112: 2130-7.
12. Hanigan MH, Frierson HF Jr. Immunohistochemical detection of gamma-glutamyl transpeptidase in normal human tissue. J Histochem Cytochem 1996; 44: 1101-8.
13. Stark A-A, Zeiger E, Pagano DA. Glutathione metabolism by glutamyl transpeptidase leads to lipid peroxidation: characterization of the system and relevance to hepatocarcinogenesis. Carcinogenesis 1993; 14: 183-89.
14. Kappus H, Siest H. Toxic drug effects associated with oxygen metabolism: Redox cycling and lipid peroxidation. Experientia 1981; 37: 1233-41.
15. Paolicchi A, Minotti G, Tonarelli P, Tongiani R, De Cesare D, Mezzetti A, et al. Gamma-glutamyl transpeptidase-dependent iron reduction and low density lipoprotein oxidation: a potential mechanism in atherosclerosis. J Invest Med 1999; 47: 151-60.
16. Whitfield JB, Zhu G, Nestler JE, Heath AC, Martin NG. Genetic covariation between serum gammaglutamyltransferase activity and cardiovascular risk factors. Clin Chem 2002; 48: 1426-31.
17. Nilssen O, Forde OH, Brenn T. The Tromso Study. Distribution and population determinants of gamma-glutamyltransferase. Am J Epidemiol 1990; 132: 318-26.
18. Anton RF, Stout RL, Roberts JS, Allen JP. The effect of drinking intensity and frequency on serum carbohydrate-deficient transferrin and gamma-glutamyl transferase levels in outpatient alcoholics. Alcohol Clin Exp Res 1998; 22: 1456-62.
19. Dominici S, Paolicchi A, Lorenzini E, Maellaro E, Comporti M, Pieri L, et al. Gamma-glutamyltransferase-dependent prooxidant reactions: a factor in multiple processes. BioFactors 2003; 17: 187-98.
20. Paolicchi A, Emdin M, Passino C, Lorenzini E, Titta F, Marchi S, et al. Beta-lipoprotein- and LDL-associated serum γ-glutamyltransferase in patients with coronary atherosclerosis. Atherosclerosis 2005 Aug 17; [Epub ahead of print].
21. Pang JH, Jiang MJ, Chen YL, Wang FW, Chu SH, Chan LY. Increased ferritin gene expression in atherosclerotic lesions. J Clin Invest 1996; 97: 2204-12.
22. Libby P, Theroux P. Pathophysiology of coronary artery disease. Circulation 2005; 111: 3481-8.
23. Anderson ME, Allison RD, Meister A. Interconversion of leukotrienes catalyzed by purified gammaglutamyl transpeptidase: concomitant formation of leukotriene D4 and gamma-glutamyl aminoacids. Proc Natl Acad Sci USA 1982; 79: 1088-91.