GlnR-mediated regulation of nitrogen metabolism in Lactococcus lactis

Journal of Bacteriology

Volumn 188, Issue 13, 2006, Pages 4978-4982

  Larsen, Rasmus ^a,b   Kloosterman, Tomas G ^a   Kok, Jan ^a   Kuipers, Oscar P ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b Instituto Gulbenkian de Ciência ^*  (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

AMMONIA; BACTERIAL PROTEIN; GLUTAMINE; PROTEIN CODY; PROTEIN GLNR; REGULATOR PROTEIN; UNCLASSIFIED DRUG;

AMTB GENE; ARTICLE; BACTERIAL GENE; DNA FLANKING REGION; GENETIC CONSERVATION; GENETIC TRANSCRIPTION; GLNA GENE; GLNK GENE; GLNP GENE; GLNQ GENE; GLNR GENE; LACTOCOCCUS LACTIS; METABOLIC REGULATION; NITROGEN METABOLISM; NONHUMAN; OPERON; PRIORITY JOURNAL;

BACTERIAL PROTEINS; BASE SEQUENCE; GENE EXPRESSION REGULATION, BACTERIAL; GLUTAMINE; LACTOCOCCUS LACTIS; MOLECULAR SEQUENCE DATA; NITROGEN; OPERON; QUATERNARY AMMONIUM COMPOUNDS; TRANS-ACTIVATORS;

LACTOCOCCUS LACTIS;

EID: 33745470323     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/JB.00025-06     Document Type: Article

References (32)

1. Belitsky, B. R., L. V. Wray, Jr., S. H. Fisher, D. E. Bohannon, and A. L. Sonenshein. 2000. Role of TnrA in nitrogen source-dependent repression of Bacillus subtilis glutamate synthase gene expression. J. Bacteriol. 182:5939-5947.
2. Bolotin, A., P. Wincker, S. Mauger, O. Jaillon, K. Malarme, J. Weissenbach, S. D. Ehrlich, and A. Sorokin. 2001. The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403. Genome Res. 11:731-753.
3. Brandenburg, J. L., L. V. Wray, Jr., L. Beier, H. Jarmer, H. H. Saxild, and S. H. Fisher. 2002. Roles of PucR, GlnR, and TnrA in regulating expression of the Bacillus subtilis ure P3 promoter. J. Bacteriol. 184:6060-6064.
4. Brown, S. W., and A. L. Sonenshein. 1996. Autogenous regulation of the Bacillus subtilis glnRA operon. J. Bacteriol. 178:2450-2454.
5. Chopin, A. 1993. Organization and regulation of genes for amino acid biosynthesis in lactic acid bacteria. FEMS Microbiol. Rev. 12:21-37.
6. Deguchi, Y., and T. Morishita. 1992. Nutritional requirements in multiple auxotrophic lactic acid bacteria: genetic lesions affecting amino acid biosynthesis pathways in Lactococcus lactis, Enterococcus faecium and Pediococcus acidilactici. Biosci. Biotechnol. Biochem. 56:913-918.
7. den Hengst, C. D., P. Curley, R. Larsen, G. Buist, A. Nauta, D. van Sinderen, O. P. Kuipers, and J. Kok. 2005. Probing direct interactions between CodY and the oppD promoter of Lactococcus lactis. J. Bacteriol. 187:512-521.
8. den Hengst, C. D., S. A. F. T. van Hijum, J. M. W. Geurts, A. Nauta, J. Kok, and O. P. Kuipers. 2005. The Lactococcus lactis CodY regulon: identification of a conserved cis-regulatory element. J. Biol. Chem. 280:34332-34342.
9. Deuel, T. F., and S. Prusiner. 1974. Regulation of glutamine synthetase from Bacillus subtilis by divalent cations, feedback inhibitors, and L-glutamine. J. Biol. Chem. 249:257-264.
10. Fisher, S. H. 1999. Regulation of nitrogen metabolism in Bacillus subtilis: vive la difference! Mol. Microbiol. 32:223-232.
11. Gajic, O. 2003. Relationship between MDR proteins, bacteriocin production and proteolysis in Lactococcus lactis. Ph.D. thesis. University of Groningen, Groningen, The Netherlands.
12. Gasson, M. J. 1983. Plasmid complements of Streptococcus lactis NCDO 712 and other lactic streptococci after protoplast-induced curing. J. Bacteriol. 154:1-9.
13. Godon, J. J., C. Delorme, J. Bardowski, M. C. Chopin, S. D. Ehrlich, and P. Renault. 1993. Gene inactivation in Lactococcus lactis: branched-chain amino acid biosynthesis. J. Bacteriol. 175:4383-4390.
14. Guédon, E., P. Serror, S. D. Ehrlich, P. Renault, and C. Delorme. 2001. Pleiotropic transcriptional repressor CodY senses the intracellular pool of branched-chain amino acids in Lactococcus lactis. Mol. Microbiol. 40:1227-1239.
15. Kok, J., and G. Buist. 2003. Genetics of proteolysis in Lactococcus lactis, p. 189-223. In B. Wood (ed.), Genetics of lactic acid bacteria. Kluwer, New York, N.Y.
16. Kuipers, O. P., A. de Jong, R. J. S. Baerends, S. A. F. T. van Hijum, A. L. Zomer, H. A. Karsens, C. D. den Hengst, N. E. Kramer, G. Buist, and J. Kok. 2002. Transcriptome analysis and related databases of Lactococcus lactis. Antonie Leeuwenhoek 82:113-122.
17. Larsen, R., G. Buist, O. P. Kuipers, and J. Kok. 2004. ArgR and AhrC are both required for regulation of arginine metabolism in Lactococcus lactis. J. Bacteriol. 186:1147-1157.
18. Leenhouts, K., G. Buist, A. Bolhuis, A. ten Berge, J. Kiel, I. Mierau, M. Dabrowska, G. Venema, and J. Kok. 1996. A general system for generating unlabelled gene replacements in bacterial chromosomes. Mol. Gen. Genet. 253:217-224.
19. Nakano, M. M., T. Hoffmann, Y. Zhu, and D. Jahn. 1998. Nitrogen and oxygen regulation of Bacillus subtilis nasDEF encoding NADH-dependent nitrite reductase by TnrA and ResDE. J. Bacteriol. 180:5344-5350.
20. Poolman, B., and W. N. Konings. 1988. Relation of growth of Streptococcus lactis and Streptococcus cremoris to amino acid transport. J. Bacteriol. 170:700-707.
21. Sanders, J. W., G. Venema, J. Kok, and K. Leenhouts. 1998. Identification of a sodium chloride-regulated promoter in Lactococcus lactis by single-copy chromosomal fusion with a reporter gene. Mol. Gen. Genet. 257:681-685.
22. Schultz, A. C., P. Nygaard, and H. H. Saxild. 2001. Functional analysis of 14 genes that constitute the purine catabolic pathway in Bacillus subtilis and evidence for a novel regulon controlled by the PucR transcription activator. J. Bacteriol. 183:3293-3302.
23. Schuurman-Wolters, G. K., and B. Poolman. 2005. Substrate specificity and ionic regulation of GlnPQ from Lactococcus lactis. An ATP-binding cassette transporter with four extracytoplasmic substrate-binding domains. J. Biol. Chem. 280:23785-23790.
24. 23a. Ternagi, B. E. and W. E. Sandine. 1975. Improved medium for lactic streptococci and their bacteriophages. Appl. Microbiol. 29:807-813.
25. Thijs, G., M. Lescot, K. Marchal, S. Rombauts, B. de Moor, P. Rouze, and Y. Moreau. 2001. A higher-order background model improves the detection of promoter regulatory elements by Gibbs sampling. Bioinformatics 17:1113-1122.
26. Thijs, G., K. Marchal, M. Lescot, S. Rombauts, B. de Moor, P. Rouze, and Y. Moreau. 2002. A Gibbs sampling method to detect overrepresented motifs in the upstream regions of coexpressed genes. J. Comput. Biol. 9:447-464.
27. Thomas, G., G. Coutts, and M. Merrick. 2000. The glnKamtB operon: a conserved gene pair in prokaryotes. Trends Genet. 16:11-14.
28. van Hijum, S. A. F. T., A. de Jong, R. J. S. Baerends, H. A. Karsens, N. E. Kramer, R. Larsen, C. D. den Hengst, C. J. Albers, J. Kok, and O. P. Kuipers. 2005. A generally applicable validation scheme for the assessment of factors involved in reproducibility and quality of DNA-microarray data. BMC Genomics 6:77.
29. van Hijum, S. A. F. T., J. Garcia de la Nava, O. Trelles, J. Kok, and O. P. Kuipers. 2003. MicroPrep: a cDNA microarray data pre-processing framework. Appl. Bioinformatics 2:241-244.
30. Wray, L. V., Jr., A. E. Ferson, and S. H. Fisher. 1997. Expression of the Bacillus subtilis ureABC operon is controlled by multiple regulatory factors including CodY, GlnR, TnrA, and Spo0H. J. Bacteriol. 179:5494-5501.
31. Wray, L. V., Jr., A. E. Ferson, K. Rohrer, and S. H. Fisher. 1996. TnrA, a transcription factor required for global nitrogen regulation in Bacillus subtilis. Proc. Natl. Acad. Sci. USA 93:8841-8845.
32. Yoshida, K., H. Yamaguchi, M. Kinehara, Y. Ohki, Y. Nakaura, and Y. Fujita. 2003. Identification of additional TnrA-regulated genes of Bacillus subtilis associated with a TnrA box. Mol. Microbiol. 49:157-165.