-
1
-
-
2442669295
-
Akt and Hypoxia-inducible-factor-1 independently enhance tumor growth and angiogenesis
-
Arsham A.M, Plas D.R, Thompson C.B, Simon M.C. (2004) Akt and Hypoxia-inducible-factor-1 independently enhance tumor growth and angiogenesis. Cancer Res. 64: 3500-3507
-
(2004)
Cancer Res.
, vol.64
, pp. 3500-3507
-
-
Arsham, A.M.1
Plas, D.R.2
Thompson, C.B.3
Simon, M.C.4
-
2
-
-
0041382820
-
The hypoxic response of tumors is dependent on their microenvironment
-
Blouw B., Song H., Tihan T., Bosze J., Ferrara N., Gerber H.P., Johnson R.S., Bergers G. (2003) The hypoxic response of tumors is dependent on their microenvironment. Cancer Cell 4:133-146
-
(2003)
Cancer Cell
, vol.4
, pp. 133-146
-
-
Blouw, B.1
Song, H.2
Tihan, T.3
Bosze, J.4
Ferrara, N.5
Gerber, H.P.6
Johnson, R.S.7
Bergers, G.8
-
3
-
-
9644268819
-
The potential therapeutic application of targeting HIF-1 using gene therapy or small molecule approaches
-
Brown L.M., Williams K.J., Cowen R.L., Melillo G., Sausville E., Stratford I.J.(2003) The potential therapeutic application of targeting HIF-1 using gene therapy or small molecule approaches. Proc. AACR. 44: 4633
-
(2003)
Proc. AACR.
, vol.44
, pp. 4633
-
-
Brown, L.M.1
Williams, K.J.2
Cowen, R.L.3
Melillo, G.4
Sausville, E.5
Stratford, I.J.6
-
4
-
-
0032581277
-
Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumor angiogenesis
-
Carmeliet P., Dor Y., Herbert J.M., Fukumura D., Brusselmans K., Dewerchin M., Neeman M., Bono F., Abramovitch R., Maxwell P., Koch C.J., Ratcliffe P., Moons L., Jain R.K., Collen D., Keshert E., Keshet E. (1998) Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumor angiogenesis. Nature 394: 485-490
-
(1998)
Nature
, vol.394
, pp. 485-490
-
-
Carmeliet, P.1
Dor, Y.2
Herbert, J.M.3
Fukumura, D.4
Brusselmans, K.5
Dewerchin, M.6
Neeman, M.7
Bono, F.8
Abramovitch, R.9
Maxwell, P.10
Koch, C.J.11
Ratcliffe, P.12
Moons, L.13
Jain, R.K.14
Collen, D.15
Keshert, E.16
Keshet, E.17
-
5
-
-
0032891708
-
Induction and nuclear translocation of hypoxia-inducible factor-1 (HIF-1): Heterodimerization with ARNT is not necessary for nuclear accumulation of HIF-1alpha
-
Chilov D., Camenisch G., Kvietikova I., Ziegler U., Gassmann M., Wenger R.H. (1999) Induction and nuclear translocation of hypoxia-inducible factor-1 (HIF-1): Heterodimerization with ARNT is not necessary for nuclear accumulation of HIF-1alpha. J. Cell Sci. 112: 1203-1212
-
(1999)
J. Cell Sci
, vol.112
, pp. 1203-1212
-
-
Chilov, D.1
Camenisch, G.2
Kvietikova, I.3
Ziegler, U.4
Gassmann, M.5
Wenger, R.H.6
-
7
-
-
0030691795
-
Oncogenes in tumor metabolism, tumorigenesis, and apoptosis
-
Dang C.V., Lewis B.C., Dolde C., Dang G., Shim H. (1997) Oncogenes in tumor metabolism, tumorigenesis, and apoptosis. J. Bioenergetics & Biomembranes 29: 345-354
-
(1997)
J. Bioenergetics & Biomembranes
, vol.29
, pp. 345-354
-
-
Dang, C.V.1
Lewis, B.C.2
Dolde, C.3
Dang, G.4
Shim, H.5
-
8
-
-
0041357164
-
BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis
-
Danial N.N., Gramm C.F., Scorrano L., Zhang C.Y., Krauss S., Ranger A.M., Datta S.R., Greenberg M.E., Licklider L.J., Lowell B.B., Gygi S.P., Korsmeyer S.J.(2003) BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis. Nature 424: 952-956
-
(2003)
Nature
, vol.424
, pp. 952-956
-
-
Danial, N.N.1
Gramm, C.F.2
Scorrano, L.3
Zhang, C.Y.4
Krauss, S.5
Ranger, A.M.6
Datta, S.R.7
Greenberg, M.E.8
Licklider, L.J.9
Lowell, B.B.10
Gygi, S.P.11
Korsmeyer, S.J.12
-
9
-
-
0021100690
-
Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei
-
Dignam J.D., Lebovitz R.M., Roeder R.G. (1983) Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11:1475-1489
-
(1983)
Nucleic Acids Res
, vol.11
, pp. 1475-1489
-
-
Dignam, J.D.1
Lebovitz, R.M.2
Roeder, R.G.3
-
10
-
-
0032476059
-
Hypoxia regulates beta-enolase and pyruvate kinase-M promoters by modulating Sp1/Sp3 binding to a conserved GC element
-
Discher D.J., Bishopric N.H., Wu X., Peterson C.A., Webster K.A. (1998) Hypoxia regulates beta-enolase and pyruvate kinase-M promoters by modulating Sp1/Sp3 binding to a conserved GC element. J. Biol. Chem. 273: 26087-26093
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 26087-26093
-
-
Discher, D.J.1
Bishopric, N.H.2
Wu, X.3
Peterson, C.A.4
Webster, K.A.5
-
11
-
-
0042860122
-
Metabolism meets cell death
-
Downward J. (2003) Metabolism meets cell death. Nature 424:896-897
-
(2003)
Nature
, vol.424
, pp. 896-897
-
-
Downward, J.1
-
12
-
-
0000069903
-
New Perspectives on Carbohydrate Metabolism in tumor cells
-
Beitner R. (eds) CRC Press, Boca Raton, Florida
-
Eigenbrodt E., Fister P., Reinacher M. (1985). New Perspectives on Carbohydrate Metabolism in tumor cells. In: Beitner R. (eds) Regulation of Carbohydrate Metabolism. CRC Press, Boca Raton, Florida pp. 142-178
-
(1985)
Regulation of Carbohydrate Metabolism
, pp. 142-178
-
-
Eigenbrodt, E.1
Fister, P.2
Reinacher, M.3
-
13
-
-
2542561169
-
Akt stimulates aerobic glycolysis in cancer cells
-
Elstrom R.L., Bauer D.E., Buzzai M., Karnauskas R., Harris M.H., Plas D.R., Zhuang H., Cinalli R.M., Alavi A., Rudin C.M., Thompson C.B. (2004) Akt stimulates aerobic glycolysis in cancer cells. Cancer Res. 64: 3892-3899
-
(2004)
Cancer Res.
, vol.64
, pp. 3892-3899
-
-
Elstrom, R.L.1
Bauer, D.E.2
Buzzai, M.3
Karnauskas, R.4
Harris, M.H.5
Plas, D.R.6
Zhuang, H.7
Cinalli, R.M.8
Alavi, A.9
Rudin, C.M.10
Thompson, C.B.11
-
14
-
-
0036468251
-
Metabolic changes detected by in vivo Magnetic Resonace studies of HEPA-1 wild-type and tumors deficient in hypoxia-inducible factor-1β (HIF-1β): Evidence of an anabolic role for the HIF-1 pathway
-
Griffiths J.R., McSheehy P.M., Robinson S.P., Troy H., Chung Y.L., Leek R.D., Williams K.J., Stratford I.J., Harris A.L. and Stubbs M. (2002). Metabolic changes detected by in vivo Magnetic Resonace studies of HEPA-1 wild-type and tumors deficient in hypoxia-inducible factor-1β (HIF-1β): Evidence of an anabolic role for the HIF-1 pathway. Cancer Res. 62: 688-695
-
(2002)
Cancer Res.
, vol.62
, pp. 688-695
-
-
Griffiths, J.R.1
McSheehy, P.M.2
Robinson, S.P.3
Troy, H.4
Chung, Y.L.5
Leek, R.D.6
Williams, K.J.7
Stratford, I.J.8
Harris, A.L.9
Stubbs, M.10
-
15
-
-
0041594045
-
Introduction
-
Harrigan GC, Goodacre R. (eds) Kluwer Academic Publishers, Boston
-
Harrigan G.C., Goodacre R. (2003) Introduction. In: Harrigan GC, Goodacre R. (eds) Metabolic Profiling, Its role in biomarker discovery and gene function analysis. Kluwer Academic Publishers, Boston, pp. 1-8
-
(2003)
Metabolic Profiling, Its Role in Biomarker Discovery and Gene Function Analysis
, pp. 1-8
-
-
Harrigan, G.C.1
Goodacre, R.2
-
16
-
-
0036359548
-
Hypoxia - A key regulatory factor in tumor growth
-
Harris A.L. (2002). Hypoxia-a key regulatory factor in tumor growth. Nature Rev. Cancer 2: 38-47
-
(2002)
Nature Rev. Cancer
, vol.2
, pp. 38-47
-
-
Harris, A.L.1
-
17
-
-
33745434013
-
Novel Role of fumarate in antagonizing VHL function
-
Isaacs J., Jung Y.J., Lee S., Torres-Cabala C., Merino M., Trepel J., Zbar B., Toro J., Linehan M., Neckers L. (2004) Novel Role of fumarate in antagonizing VHL function. Euro. J. Cancer Suppl. 8: 104
-
(2004)
Euro. J. Cancer
, Issue.SUPPL. 8
, pp. 104
-
-
Isaacs, J.1
Jung, Y.J.2
Lee, S.3
Torres-Cabala, C.4
Merino, M.5
Trepel, J.6
Zbar, B.7
Toro, J.8
Linehan, M.9
Neckers, L.10
-
18
-
-
0035917808
-
2-regulated prolyl hydroxylation
-
2-regulated prolyl hydroxylation. Science 292:468-472
-
(2001)
Science
, vol.292
, pp. 468-472
-
-
Jaakkola, P.1
Mole, D.R.2
Tian, Y.M.3
Wilson, M.I.4
Gielbert, J.5
Gaskell, S.J.6
Kriegsheim, A.V.7
Hebestreit, H.F.8
Mukherji, M.9
Schofield, C.J.10
Maxwell, P.H.11
Pugh, C.W.12
Ratcliffe, P.J.13
-
19
-
-
20144382255
-
The Role of Hypoxia-Inducible Factor-1 in Three-dimensional Tumor Growth, Apoptosis, and Regulation by the Insulin-Signaling Pathway
-
Leek R.D., Stratford I.J. and Harris A.L. (2005) The Role of Hypoxia-Inducible Factor-1 in Three-dimensional Tumor Growth, Apoptosis, and Regulation by the Insulin-Signaling Pathway. Cancer Res. 65: 4147-4152
-
(2005)
Cancer Res.
, vol.65
, pp. 4147-4152
-
-
Leek, R.D.1
Stratford, I.J.2
Harris, A.L.3
-
20
-
-
0038339194
-
Hepatocyte growth factor induces apoptosis through the extrinsic pathway in hepatoma cells: Favouring role of hypoxia-inducible factor-1 deficiency
-
Matteucci E., Modora S., Simone M., Desiderio M.A. (2003) Hepatocyte growth factor induces apoptosis through the extrinsic pathway in hepatoma cells: Favouring role of hypoxia-inducible factor-1 deficiency. Oncogene 22: 4062-4073
-
(2003)
Oncogene
, vol.22
, pp. 4062-4073
-
-
Matteucci, E.1
Modora, S.2
Simone, M.3
Desiderio, M.A.4
-
21
-
-
0030816109
-
Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth
-
Maxwell P.H., Dachs G.U., Gleadle J.M., Nicholls L.G., Harris A.L., Stratford I.J., Hankinson O., Pugh C.W. and Ratcliffe P.J. (1997) Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth. Proc. Natl. Acad. Sci. USA 94: 8104-8109
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 8104-8109
-
-
Maxwell, P.H.1
Dachs, G.U.2
Gleadle, J.M.3
Nicholls, L.G.4
Harris, A.L.5
Stratford, I.J.6
Hankinson, O.7
Pugh, C.W.8
Ratcliffe, P.J.9
-
23
-
-
4944256273
-
Proteomic and metabolomic analysis of vascular smooth muscle cells: Role of PKCdelta
-
Mayr M., Siow R., Chung Y.L., Mayr U., Griffiths J.R., Xu Q. (2004) Proteomic and metabolomic analysis of vascular smooth muscle cells: Role of PKCdelta. Cir.c Res. 94: 87-96
-
(2004)
Circ. Res.
, vol.94
, pp. 87-96
-
-
Mayr, M.1
Siow, R.2
Chung, Y.L.3
Mayr, U.4
Griffiths, J.R.5
Xu, Q.6
-
24
-
-
4143110440
-
HIF-1: Master and commander of the hypoxic world. A pharmacological approach to its regulation by siRNAs
-
Mazure N.M., Brahimi-Horn M.C., Berta M.A., Benizri E., Bilton R.L., Dayan F., Ginouves A., Berra E., Pouyssegur J. (2004) HIF-1: Master and commander of the hypoxic world. A pharmacological approach to its regulation by siRNAs. Biochem. Pharmacol. 68: 971-980
-
(2004)
Biochem. Pharmacol.
, vol.68
, pp. 971-980
-
-
Mazure, N.M.1
Brahimi-Horn, M.C.2
Berta, M.A.3
Benizri, E.4
Bilton, R.L.5
Dayan, F.6
Ginouves, A.7
Berra, E.8
Pouyssegur, J.9
-
25
-
-
0032056350
-
1 H MRS markers of tumor growth in intrasplenic tumors and liver metastasis induced by injection of HT-29 cells in nude mice spleen
-
Moreno A., Lopez L.A., Fabra A., Arus C. (1998) 1 H MRS markers of tumor growth in intrasplenic tumors and liver metastasis induced by injection of HT-29 cells in nude mice spleen. NMR Biomed. 11: 93-106
-
(1998)
NMR Biomed.
, vol.11
, pp. 93-106
-
-
Moreno, A.1
Lopez, L.A.2
Fabra, A.3
Arus, C.4
-
26
-
-
0036316013
-
A functional screen for Myc-responsive genes reveals serine hydroxymethyltransferase, a major source of the one-carbon unit for cell metabolism
-
Nikiforov M.A., Chandriani S., O'Connell B., Petrenko O., Kotenko I., Beavis A., Sedivy J.M, Cole M.D. (2002) A functional screen for Myc-responsive genes reveals serine hydroxymethyltransferase, a major source of the one-carbon unit for cell metabolism. Mol. Cell. Bio. 22: 5793-5800
-
(2002)
Mol. Cell. Bio.
, vol.22
, pp. 5793-5800
-
-
Nikiforov, M.A.1
Chandriani, S.2
O'Connell, B.3
Petrenko, O.4
Kotenko, I.5
Beavis, A.6
Sedivy, J.M.7
Cole, M.D.8
-
27
-
-
0032053169
-
Oxygen sensing, hypoxia-inducible factor-1 and the regulation of mammalian gene expression
-
Ratcliffe P.J., O'Rourke J.F., Maxwell P.H., Pugh C.W. (1998) Oxygen sensing, hypoxia-inducible factor-1 and the regulation of mammalian gene expression. J. Exper. Bio. 201: 1153-1162
-
(1998)
J. Exper. Bio.
, vol.201
, pp. 1153-1162
-
-
Ratcliffe, P.J.1
O'Rourke, J.F.2
Maxwell, P.H.3
Pugh, C.W.4
-
28
-
-
0035027828
-
The transcription factor HIF-1 is a necessary mediator of the Pasteur effect in mammalian cells
-
Seagroves T.N., Ryan H.E., Lu H., Wouters B.G., Knapp M., Thibault P., Laderoute K., and Johnson R.S. (2001) The transcription factor HIF-1 is a necessary mediator of the Pasteur effect in mammalian cells. Mol. Cell. Bio. 21:3436-3444
-
(2001)
Mol. Cell. Bio.
, vol.21
, pp. 3436-3444
-
-
Seagroves, T.N.1
Ryan, H.E.2
Lu, H.3
Wouters, B.G.4
Knapp, M.5
Thibault, P.6
Laderoute, K.7
Johnson, R.S.8
-
29
-
-
0033991530
-
Expression of hypoxia-inducible factor 1: Mechanisms and consequences
-
Semenza G.L. (2000) Expression of hypoxia-inducible factor 1: Mechanisms and consequences. Biochem. Pharmacol. 59: 47-53
-
(2000)
Biochem. Pharmacol.
, vol.59
, pp. 47-53
-
-
Semenza, G.L.1
-
30
-
-
0034901463
-
Hypoxia-inducible-factor 1: Oxygen homeostasis and disease pathophysiology
-
Semenza G.L. (2001) Hypoxia-inducible-factor 1:oXygen homeostasis and disease pathophysiology. Trends Mol. Med. 7: 345-350
-
(2001)
Trends Mol. Med.
, vol.7
, pp. 345-350
-
-
Semenza, G.L.1
-
31
-
-
0028068606
-
Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1
-
Semenza G.L., Roth P.H., Fang H,M. and Wang G.L. (1994). Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1. J. Biol. Chem. 269: 23757-23763
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 23757-23763
-
-
Semenza, G.L.1
Roth, P.H.2
Fang, H.M.3
Wang, G.L.4
-
32
-
-
12244257553
-
Understanding the tumor metabolic phenotype in the genomic era
-
Stubbs M., Bashford C.L., Griffiths J.R. (2003) Understanding the tumor metabolic phenotype in the genomic era. Curr. Mol. Med. 3: 49-59
-
(2003)
Curr. Mol. Med.
, vol.3
, pp. 49-59
-
-
Stubbs, M.1
Bashford, C.L.2
Griffiths, J.R.3
-
33
-
-
33745435460
-
Glucose uptake in HIF-1β deficient Hepa-1 tumors and wild type
-
Troy, H., Chung, Y.L., Stubbs, M., Griffiths, J.R.G., Mayr, M., Ly, L., Stratford, I., Williams, K., Latigo, J., Perumal, M. and Aboagye, E. (2004). Glucose uptake in HIF-1β deficient Hepa-1 tumors and wild type. Abstract ISMRM workshop on Advances in Experimental and Clinical Cancer Research, pp. 163-164
-
(2004)
Abstract ISMRM Workshop on Advances in Experimental and Clinical Cancer Research
, pp. 163-164
-
-
Troy, H.1
Chung, Y.L.2
Stubbs, M.3
Griffiths, J.R.G.4
Mayr, M.5
Ly, L.6
Stratford, I.7
Williams, K.8
Latigo, J.9
Perumal, M.10
Aboagye, E.11
-
34
-
-
0042761742
-
Evolution of the coordinate regulation of glycolytic enzyme genes by hypoxia
-
Webster KA. (2003) Evolution of the coordinate regulation of glycolytic enzyme genes by hypoxia. J. Exper. Bio. 206: 2911-2922
-
(2003)
J. Exper. Bio.
, vol.206
, pp. 2911-2922
-
-
Webster, K.A.1
-
35
-
-
0037050215
-
A protective role for HIF-1 in response to redox manipulation and glucose deprivation: Implications for tumorigensis
-
Williams K.J., Telfer B.A., Airley RA., Peters J.P.W., Sheridan M.R., van der Kogel A.J., Harris A.L. and Stratford IJ. (2002) A protective role for HIF-1 in response to redox manipulation and glucose deprivation: Implications for tumorigensis. Oncogene 21: 282-290
-
(2002)
Oncogene
, vol.21
, pp. 282-290
-
-
Williams, K.J.1
Telfer, B.A.2
Airley, R.A.3
Peters, J.P.W.4
Sheridan, M.R.5
van der Kogel, A.J.6
Harris, A.L.7
Stratford, I.J.8
-
36
-
-
0029888061
-
The role of the aryl hydrocarbon receptor nuclear translocator (ARNT) in hypoxic induction of gene expression. Studies in ARNT-deficient cells
-
Wood S.M., Gleadle J.M., Pugh C.W., Hankinson O., Ratcliffe P.J. (1996) The role of the aryl hydrocarbon receptor nuclear translocator (ARNT) in hypoxic induction of gene expression. Studies in ARNT-deficient cells. J. Biol. Chem. 271:15117-23
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 15117-15123
-
-
Wood, S.M.1
Gleadle, J.M.2
Pugh, C.W.3
Hankinson, O.4
Ratcliffe, P.J.5
|