메뉴 건너뛰기




Volumn 1, Issue 4, 2005, Pages 293-303

Metabolic profiling of hypoxia-inducible factor-1β-deficient and wild type Hepa-1 cells: Effects of hypoxia measured by 1H magnetic resonance spectroscopy

Author keywords

1H Magnetic resonance spectroscopy; Cultured cells; HIF 1 ; Hypoxia; Metabolites

Indexed keywords


EID: 33745464735     PISSN: 15733882     EISSN: 15733890     Source Type: Journal    
DOI: 10.1007/s11306-005-0009-8     Document Type: Article
Times cited : (14)

References (36)
  • 1
    • 2442669295 scopus 로고    scopus 로고
    • Akt and Hypoxia-inducible-factor-1 independently enhance tumor growth and angiogenesis
    • Arsham A.M, Plas D.R, Thompson C.B, Simon M.C. (2004) Akt and Hypoxia-inducible-factor-1 independently enhance tumor growth and angiogenesis. Cancer Res. 64: 3500-3507
    • (2004) Cancer Res. , vol.64 , pp. 3500-3507
    • Arsham, A.M.1    Plas, D.R.2    Thompson, C.B.3    Simon, M.C.4
  • 3
    • 9644268819 scopus 로고    scopus 로고
    • The potential therapeutic application of targeting HIF-1 using gene therapy or small molecule approaches
    • Brown L.M., Williams K.J., Cowen R.L., Melillo G., Sausville E., Stratford I.J.(2003) The potential therapeutic application of targeting HIF-1 using gene therapy or small molecule approaches. Proc. AACR. 44: 4633
    • (2003) Proc. AACR. , vol.44 , pp. 4633
    • Brown, L.M.1    Williams, K.J.2    Cowen, R.L.3    Melillo, G.4    Sausville, E.5    Stratford, I.J.6
  • 5
    • 0032891708 scopus 로고    scopus 로고
    • Induction and nuclear translocation of hypoxia-inducible factor-1 (HIF-1): Heterodimerization with ARNT is not necessary for nuclear accumulation of HIF-1alpha
    • Chilov D., Camenisch G., Kvietikova I., Ziegler U., Gassmann M., Wenger R.H. (1999) Induction and nuclear translocation of hypoxia-inducible factor-1 (HIF-1): Heterodimerization with ARNT is not necessary for nuclear accumulation of HIF-1alpha. J. Cell Sci. 112: 1203-1212
    • (1999) J. Cell Sci , vol.112 , pp. 1203-1212
    • Chilov, D.1    Camenisch, G.2    Kvietikova, I.3    Ziegler, U.4    Gassmann, M.5    Wenger, R.H.6
  • 6
    • 0033079597 scopus 로고    scopus 로고
    • Oncogenic alterations of metabolism
    • Dang C.V., Semenza G.L. (1999). Oncogenic alterations of metabolism. Trends Biochem. Sci. 24: 68-72
    • (1999) Trends Biochem. Sci. , vol.24 , pp. 68-72
    • Dang, C.V.1    Semenza, G.L.2
  • 9
    • 0021100690 scopus 로고
    • Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei
    • Dignam J.D., Lebovitz R.M., Roeder R.G. (1983) Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11:1475-1489
    • (1983) Nucleic Acids Res , vol.11 , pp. 1475-1489
    • Dignam, J.D.1    Lebovitz, R.M.2    Roeder, R.G.3
  • 10
    • 0032476059 scopus 로고    scopus 로고
    • Hypoxia regulates beta-enolase and pyruvate kinase-M promoters by modulating Sp1/Sp3 binding to a conserved GC element
    • Discher D.J., Bishopric N.H., Wu X., Peterson C.A., Webster K.A. (1998) Hypoxia regulates beta-enolase and pyruvate kinase-M promoters by modulating Sp1/Sp3 binding to a conserved GC element. J. Biol. Chem. 273: 26087-26093
    • (1998) J. Biol. Chem. , vol.273 , pp. 26087-26093
    • Discher, D.J.1    Bishopric, N.H.2    Wu, X.3    Peterson, C.A.4    Webster, K.A.5
  • 11
    • 0042860122 scopus 로고    scopus 로고
    • Metabolism meets cell death
    • Downward J. (2003) Metabolism meets cell death. Nature 424:896-897
    • (2003) Nature , vol.424 , pp. 896-897
    • Downward, J.1
  • 12
    • 0000069903 scopus 로고
    • New Perspectives on Carbohydrate Metabolism in tumor cells
    • Beitner R. (eds) CRC Press, Boca Raton, Florida
    • Eigenbrodt E., Fister P., Reinacher M. (1985). New Perspectives on Carbohydrate Metabolism in tumor cells. In: Beitner R. (eds) Regulation of Carbohydrate Metabolism. CRC Press, Boca Raton, Florida pp. 142-178
    • (1985) Regulation of Carbohydrate Metabolism , pp. 142-178
    • Eigenbrodt, E.1    Fister, P.2    Reinacher, M.3
  • 14
    • 0036468251 scopus 로고    scopus 로고
    • Metabolic changes detected by in vivo Magnetic Resonace studies of HEPA-1 wild-type and tumors deficient in hypoxia-inducible factor-1β (HIF-1β): Evidence of an anabolic role for the HIF-1 pathway
    • Griffiths J.R., McSheehy P.M., Robinson S.P., Troy H., Chung Y.L., Leek R.D., Williams K.J., Stratford I.J., Harris A.L. and Stubbs M. (2002). Metabolic changes detected by in vivo Magnetic Resonace studies of HEPA-1 wild-type and tumors deficient in hypoxia-inducible factor-1β (HIF-1β): Evidence of an anabolic role for the HIF-1 pathway. Cancer Res. 62: 688-695
    • (2002) Cancer Res. , vol.62 , pp. 688-695
    • Griffiths, J.R.1    McSheehy, P.M.2    Robinson, S.P.3    Troy, H.4    Chung, Y.L.5    Leek, R.D.6    Williams, K.J.7    Stratford, I.J.8    Harris, A.L.9    Stubbs, M.10
  • 16
    • 0036359548 scopus 로고    scopus 로고
    • Hypoxia - A key regulatory factor in tumor growth
    • Harris A.L. (2002). Hypoxia-a key regulatory factor in tumor growth. Nature Rev. Cancer 2: 38-47
    • (2002) Nature Rev. Cancer , vol.2 , pp. 38-47
    • Harris, A.L.1
  • 19
    • 20144382255 scopus 로고    scopus 로고
    • The Role of Hypoxia-Inducible Factor-1 in Three-dimensional Tumor Growth, Apoptosis, and Regulation by the Insulin-Signaling Pathway
    • Leek R.D., Stratford I.J. and Harris A.L. (2005) The Role of Hypoxia-Inducible Factor-1 in Three-dimensional Tumor Growth, Apoptosis, and Regulation by the Insulin-Signaling Pathway. Cancer Res. 65: 4147-4152
    • (2005) Cancer Res. , vol.65 , pp. 4147-4152
    • Leek, R.D.1    Stratford, I.J.2    Harris, A.L.3
  • 20
    • 0038339194 scopus 로고    scopus 로고
    • Hepatocyte growth factor induces apoptosis through the extrinsic pathway in hepatoma cells: Favouring role of hypoxia-inducible factor-1 deficiency
    • Matteucci E., Modora S., Simone M., Desiderio M.A. (2003) Hepatocyte growth factor induces apoptosis through the extrinsic pathway in hepatoma cells: Favouring role of hypoxia-inducible factor-1 deficiency. Oncogene 22: 4062-4073
    • (2003) Oncogene , vol.22 , pp. 4062-4073
    • Matteucci, E.1    Modora, S.2    Simone, M.3    Desiderio, M.A.4
  • 23
    • 4944256273 scopus 로고    scopus 로고
    • Proteomic and metabolomic analysis of vascular smooth muscle cells: Role of PKCdelta
    • Mayr M., Siow R., Chung Y.L., Mayr U., Griffiths J.R., Xu Q. (2004) Proteomic and metabolomic analysis of vascular smooth muscle cells: Role of PKCdelta. Cir.c Res. 94: 87-96
    • (2004) Circ. Res. , vol.94 , pp. 87-96
    • Mayr, M.1    Siow, R.2    Chung, Y.L.3    Mayr, U.4    Griffiths, J.R.5    Xu, Q.6
  • 25
    • 0032056350 scopus 로고    scopus 로고
    • 1 H MRS markers of tumor growth in intrasplenic tumors and liver metastasis induced by injection of HT-29 cells in nude mice spleen
    • Moreno A., Lopez L.A., Fabra A., Arus C. (1998) 1 H MRS markers of tumor growth in intrasplenic tumors and liver metastasis induced by injection of HT-29 cells in nude mice spleen. NMR Biomed. 11: 93-106
    • (1998) NMR Biomed. , vol.11 , pp. 93-106
    • Moreno, A.1    Lopez, L.A.2    Fabra, A.3    Arus, C.4
  • 26
    • 0036316013 scopus 로고    scopus 로고
    • A functional screen for Myc-responsive genes reveals serine hydroxymethyltransferase, a major source of the one-carbon unit for cell metabolism
    • Nikiforov M.A., Chandriani S., O'Connell B., Petrenko O., Kotenko I., Beavis A., Sedivy J.M, Cole M.D. (2002) A functional screen for Myc-responsive genes reveals serine hydroxymethyltransferase, a major source of the one-carbon unit for cell metabolism. Mol. Cell. Bio. 22: 5793-5800
    • (2002) Mol. Cell. Bio. , vol.22 , pp. 5793-5800
    • Nikiforov, M.A.1    Chandriani, S.2    O'Connell, B.3    Petrenko, O.4    Kotenko, I.5    Beavis, A.6    Sedivy, J.M.7    Cole, M.D.8
  • 27
    • 0032053169 scopus 로고    scopus 로고
    • Oxygen sensing, hypoxia-inducible factor-1 and the regulation of mammalian gene expression
    • Ratcliffe P.J., O'Rourke J.F., Maxwell P.H., Pugh C.W. (1998) Oxygen sensing, hypoxia-inducible factor-1 and the regulation of mammalian gene expression. J. Exper. Bio. 201: 1153-1162
    • (1998) J. Exper. Bio. , vol.201 , pp. 1153-1162
    • Ratcliffe, P.J.1    O'Rourke, J.F.2    Maxwell, P.H.3    Pugh, C.W.4
  • 29
    • 0033991530 scopus 로고    scopus 로고
    • Expression of hypoxia-inducible factor 1: Mechanisms and consequences
    • Semenza G.L. (2000) Expression of hypoxia-inducible factor 1: Mechanisms and consequences. Biochem. Pharmacol. 59: 47-53
    • (2000) Biochem. Pharmacol. , vol.59 , pp. 47-53
    • Semenza, G.L.1
  • 30
    • 0034901463 scopus 로고    scopus 로고
    • Hypoxia-inducible-factor 1: Oxygen homeostasis and disease pathophysiology
    • Semenza G.L. (2001) Hypoxia-inducible-factor 1:oXygen homeostasis and disease pathophysiology. Trends Mol. Med. 7: 345-350
    • (2001) Trends Mol. Med. , vol.7 , pp. 345-350
    • Semenza, G.L.1
  • 31
    • 0028068606 scopus 로고
    • Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1
    • Semenza G.L., Roth P.H., Fang H,M. and Wang G.L. (1994). Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1. J. Biol. Chem. 269: 23757-23763
    • (1994) J. Biol. Chem. , vol.269 , pp. 23757-23763
    • Semenza, G.L.1    Roth, P.H.2    Fang, H.M.3    Wang, G.L.4
  • 32
    • 12244257553 scopus 로고    scopus 로고
    • Understanding the tumor metabolic phenotype in the genomic era
    • Stubbs M., Bashford C.L., Griffiths J.R. (2003) Understanding the tumor metabolic phenotype in the genomic era. Curr. Mol. Med. 3: 49-59
    • (2003) Curr. Mol. Med. , vol.3 , pp. 49-59
    • Stubbs, M.1    Bashford, C.L.2    Griffiths, J.R.3
  • 34
    • 0042761742 scopus 로고    scopus 로고
    • Evolution of the coordinate regulation of glycolytic enzyme genes by hypoxia
    • Webster KA. (2003) Evolution of the coordinate regulation of glycolytic enzyme genes by hypoxia. J. Exper. Bio. 206: 2911-2922
    • (2003) J. Exper. Bio. , vol.206 , pp. 2911-2922
    • Webster, K.A.1
  • 36
    • 0029888061 scopus 로고    scopus 로고
    • The role of the aryl hydrocarbon receptor nuclear translocator (ARNT) in hypoxic induction of gene expression. Studies in ARNT-deficient cells
    • Wood S.M., Gleadle J.M., Pugh C.W., Hankinson O., Ratcliffe P.J. (1996) The role of the aryl hydrocarbon receptor nuclear translocator (ARNT) in hypoxic induction of gene expression. Studies in ARNT-deficient cells. J. Biol. Chem. 271:15117-23
    • (1996) J. Biol. Chem. , vol.271 , pp. 15117-15123
    • Wood, S.M.1    Gleadle, J.M.2    Pugh, C.W.3    Hankinson, O.4    Ratcliffe, P.J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.