Intraparaventricular neuropeptide Y and ghrelin induce learned behaviors that report food deprivation in rats

NeuroReport

Volumn 17, Issue 7, 2006, Pages 733-737

  Jewett, David C ^a   Lefever, Timothy W ^a   Flashinski, Douglas P ^a   Koffarnus, Mikhail N ^a   Cameron, Constance R ^a   Hehli, Daniel J ^a   Grace, Martha K ^b,c,d   Levine, Allen S ^b,c,d  

^a UNIVERSITY OF WISCONSIN EAU CLAIRE   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

^c VA MEDICAL CENTER   (United States)

^d University of Minnesota   (United States)

Author keywords

Behavior; Discrimination; Eating; Food intake; Ghrelin; Hunger; Neuropeptide Y; Obesity; Operant

Indexed keywords

GHRELIN; NEUROPEPTIDE Y;

ANIMAL EXPERIMENT; ARTICLE; BEHAVIOR; CONTROLLED STUDY; DECISION MAKING; DIET; DISCRIMINATION LEARNING; EATING; FEEDING; FOOD DEPRIVATION; FOOD INTAKE; HUNGER; HYPOTHALAMUS; INSTRUMENTAL CONDITIONING; NEUROCHEMISTRY; NONHUMAN; OBESITY; PRIORITY JOURNAL; RAT; THALAMUS MIDLINE NUCLEUS;

ANIMALS; BEHAVIOR, ANIMAL; DISCRIMINATION (PSYCHOLOGY); DOSE-RESPONSE RELATIONSHIP, DRUG; FOOD DEPRIVATION; GENERALIZATION (PSYCHOLOGY); INJECTIONS, INTRAVENTRICULAR; LEARNING; NEUROPEPTIDE Y; PEPTIDE HORMONES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 33745445231     PISSN: 09594965     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.wnr.0000215767.94528.fb     Document Type: Article

References (24)

1. Thompson T, Pickens R. Stimulus properties of drugs. New York: Appleton; 1971.
2. Corwin RL, Woolverton WL, Schuster CR. Effects of cholecystokinin, D-amphetamine and fenfluramine in rats trained to discriminate 3 from 22 h of food deprivation. J Pharmacol Exp Ther 1990; 253:720-728.
3. Schuh KJ, Schaal DW, Thompson T, Cleary JP, Billington CJ, Levine AS. Insulin, 2-deoxy-D-glucose, and food deprivation as discriminative stimuli in rats. Pharmacol Biochem Behav 1994; 47:317-324.
4. Stanley BG, Leibowitz SF. Neuropeptide Y injected in the paraventricular hypothalamus: a powerful stimulant of feeding behavior. Proc Natl Acad Sci USA 1985; 82:3940-3943.
5. Jewett DC, Cleary J, Levine AS, Schaal DW, Thompson T. Effects of neuropeptide Y on food-reinforced behavior in satiated rats. Pharmacol Biochem Behav 1992; 42:207-212.
6. Jewett DC, Schaal DW, Cleary J, Thompson T, Levine AS. The discriminative stimulus effects of neuropeptide Y. Brain Res 1991; 561:165-168.
7. O'Hare E, Cleary J, Weldon DT, Pomonis JD, Billington CJ, Levine AS. Intrahypothalamic discriminative stimulus effects of neuropeptide Y. Pharmacol Biochem Behav 1998; 59:375-378.
8. Tschop M, Smiley DL, Heiman ML. Ghrelin induces adiposity in rodents. Nature 2000; 407:908-913.
9. Wren AM, Small CJ, Ward HL, Murphy KG, Dakin CL, Taheri S, et al. The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion. Endocrinology 2000; 141:4325-4328.
10. Olszewski PK, Grace MK, Billington CJ, Levine AS. Hypothalamic paraventricular injections of ghrelin: effect on feeding and c-Fos immunoreactivity. Peptides 2003; 24:919-923.
11. Paxinos G, Watson C. The rat brain in stereotaxic coordinates. Academic Press: New York; 1986.
12. Li M, Garner HR, Wessinger WD, McMillan DE. Effects of food deprivation and satiation on sensitivity to the discriminative-stimulus effects of pentobarbital in pigeons and morphine in rats. Behav Pharmacol 1995; 6:724-731.
13. Ukai M, Holtzman SG. Morphine-like discriminative stimulus effects of opioid peptides: possible modulatory role of D-Ala2-D-Leu5-enkephalin (DADL) and dynorphin A (1-13). Psychopharmacology (Berlin) 1988; 94:32-37.
14. Davidson TL, Kanoski SE, Tracy AL, Walls EK, Clegg D, Benoit SC. The interoceptive cue properties of ghrelin generalize to cues produced by food deprivation. Peptides 2005; 26:1602-1610.
15. Kim MS, Yoon CY, Park KH, Shin CS, Park KS, Kim SY, et al. Changes in ghrelin and ghrelin receptor expression according to feeding status. Neuroreport 2003; 14:1317-1320.
16. Brady LS, Smith MA, Gold PW, Herkenham M. Altered expression of hypothalamic neuropeptide mRNAs in food-restricted and food-deprived rats. Neuroendocrinology 1990; 52:441-447.
17. Chen HY, Trumbauer ME, Chen AS, Weingarth DT, Adams JR, Frazier EG, et al. Orexigenic action of peripheral ghrelin is mediated by neuropeptide Y and agouti-related protein. Endocrinology 2004; 145:2607-2612.
18. Kalra SP, Kalra PS. Neuropeptide Y: a physiological orexigen modulated by the feedback action of ghrelin and leptin. Endocrine 2003; 22:49-56.
19. Faulconbridge LF, Grill HJ, Kaplan JM. Distinct forebrain and caudal brainstem contributions to the neuropeptide Y mediation of ghrelin hyperphagia. Diabetes 2005; 54:1985-1993.
20. Horvath TL, Diano S, Sotonyi P, Heiman M, Tschop M. Minireview: ghrelin and the regulation of energy balance - a hypothalamic perspective. Endocrinology 2001; 142:4163-4169.
21. Cummings DE, Weigle DS, Frayo RS, Breen PA, Ma MK, Dellinger EP, et al. Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery. N Engl J Med 2002; 346:1623-1630.
22. Jewett DC, Cleary J, Levine AS, Schaal DW, Thompson T. Effects of neuropeptide Y, insulin, 2-deoxyglucose, and food deprivation on food-motivated behavior. Psychopharmacology (Berlin) 1995; 120:267-271.
23. Seeley RJ, Benoit SC, Davidson TL. Discriminative cues produced by NPY do not generalize to the interoceptive cues produced by food deprivation. Physiol Behav 1995; 58:1237-1241.
24. Melis MR, Mascia MS, Succu S, Torsello A, Muller EE, Deghenghi R, et al. Ghrelin injected into the paraventricular nucleus of the hypothalamus of male rats induces feeding but not penile erection. Neurosci Lett 2002; 329:339-343.