Favorable effect of chitosan sustained-release FK506 incorporated conduits on axonal regenation in rat sciatic nerve

National Medical Journal of China

Volumn 86, Issue 15, 2006, Pages 1065-1068

  Zhang, Wei Guo ^a   Lü, De Cheng ^a   Fu, Chong Yang ^a   Qü, Wei ^a  

^a DALIAN MEDICAL UNIVERSITY   (China)

Author keywords

Delayed action preparations; FK506; Nerve regeneration; Peripheral nerve

Indexed keywords

CHITOSAN; TACROLIMUS;

ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; ELECTROPHYSIOLOGY; GASTROCNEMIUS MUSCLE; HISTOPATHOLOGY; IN VIVO STUDY; MALE; MORPHOMETRICS; MUSCLE MASS; NERVE FIBER REGENERATION; NERVE TRANSPLANTATION; NEUROPROTECTION; NONHUMAN; RANDOMIZATION; RAT; SCAR FORMATION; SCIATIC NERVE; SILASTIC TUBE; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; SUSTAINED RELEASE PREPARATION;

ANIMALS; AXONS; CHITOSAN; DELAYED-ACTION PREPARATIONS; DRUG DELIVERY SYSTEMS; IMMUNOSUPPRESSIVE AGENTS; MALE; NERVE REGENERATION; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; SCIATIC NERVE; TACROLIMUS;

EID: 33745444211     PISSN: 03762491     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Chinese source. 2004, 18:33-35.
2. Zhang W, Ochi M, Takata H, et al. Influence of distal nerve segment volume on nerve regeneration in silicone tubes. Exp Neurol, 1997, 146:600-603.
3. Chinese source. 2001, 15:36-38.
4. Gold BG, Villafranca JE. Neuroimmunophilin ligands: the development of novel neuroregenerative/neuroprotective compounds. Curr Top Med Chem, 2003, 3: 1368-1375.
5. Chinese source. 2005, 85:1978-1981.
6. Chinese source. 2005, 43:1088-1090.
7. Gold BG, Storm-Dickerson T, Austin DR, et al. FK506, an immunosuppressant, increases functional recovery and axonal regeneration in the rat following axotomy of the sciatic nerve. Soc Neurosci Abstr, 1993, 19:1316.
8. Chinese source. 2005, 21:177-178.
9. Fansa H, Keilhoff G, Horn T, et al. Stimulation of Schwann cell growth and axon regeneration of peripheral nerves by the immunosuppressive drug FK506. Handchir Mikrochir Plast Chir, 1999, 31:323-329.
10. Lyons WE, George EB, Dawson TM, et al. Immunosuppressant FK506 promotes neurite outgrowth in cultures of PC-12 cells and sensory ganglia. Proc Natl Acad Sci USA, 1994, 91:3191-3195.