Inhibition of binding to fatty acid binding protein reduces the intracellular transport of fatty acids

American Journal of Physiology

Volumn 271, Issue 1 PART 1, 1996, Pages

  Luxon, Bruce A ^a,b,c,d  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Div of Gastroenterology and Hepatology ^*

^c Div of Gastroenterol and Hepatol   (United States)

^d University Health Sciences Center   (United States)

Author keywords

12 amethyl 7 nitrobenzo 2 oxa l,3 diazol mino st arate; A bromo palmitate; Cultured hepatocytes; Cytoplasmic transport; Diffusion; Fluorescence recovery after photobleaching; Liver; Models; Rate constants; organic anions

Indexed keywords

EID: 33745427045     PISSN: 00029513     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Bass, N. M. Fatty acid-binding protein expression in the liver: its regulation and relationship to the zonation of fatty acid metabolism. Mol. CellBiochem. 98: 167-176,1990.
2. Bass, N. M., M. E. Barker, J. A. Manning, A. L. Jones, and R. K. Ockner. Acinar heterogeneity of fatty acid binding protein expression in the livers of male, female and clofibrate-treated rats. Hepatology 9:12-21,1989.
3. Bass, N. M., R. M. Kaikaus, and R. K. Ockner. Physiology and molecular biology of hepatic cytosolic fatty acid-binding protein. In: Hepatic Transport and Bile Secretion: Physiology and Pathophysiology, edited by N. Tavoloni and P. D. Berk. New York: Raven, 1993, p. 421-446.
4. Bass, N. M., J. A. Manning, and R. K. Ockner. Turnover and short-term regulation of fatty acid binding protein in liver. J. Biol. Chem. 260: 9603-9607,1985.
5. Bissell, D. M., D. M. Arenson, J. J. Mäher, and F. J. Roll. Support of cultured hepatocytes by a laminin-rich gel. Evidence for a functionally significant subendothelial matrix in normal rat liver. J. Clin. Invest. 79: 801-812,1987.
6. Brandes, R., R. M. Kaikaus, N. Lysenko, R. K. Ockner, and N. M. Bass. Induction of fatty acid binding protein by peroxisome proliferators in primary hepatocyte cultures and its relationship to the induction of peroxisomal beta-oxidation. Biochim. Biophys.Acta 1034: 53-61,1990.
7. Dupou, L., A. Lopez, and J. Tocaime. Comparative study of the lateral motion of extrinsic probes and anthracene-labelled constitutive phospholipids in the plasma membrane of Chinese hamster ovary cells. Eur. J. Biochem. 7: 669-674,1988.
8. Goresky, C. A., D. S. Daly, S. Mishkin, and I. M. Arias. Uptake of labeled palmitate by the intact liver: role of intracellular binding sites. Am. J. Physiol. 234(Endocrinol. Metab. Gastrointest. Physiol. 3): E542-E553,1978.
9. Jain, R., R. Stock, S. Chary, and M. Rueter. Convection and diffusion measurements using fluorescence recovery after photobleaching and video image analysis: in vitro calibration and assessment. Microvasc. Res. 39: 77-93,1990.
10. Kaikaus, R. M., N. M. Bass, and R. K. Ockner. Functions of fatty acid binding proteins. Experientia Basel 46: 617-630,1990.
11. Kaufman, E., and R. Jain. Quantification of transport and binding parameters using fluorescence recovery after photobleaching: potential for in vivo applications. Biophys. J. 58: 873-885, 1990.
12. Kaufman, E., and R. Jain. Measurement of mass transport and reaction parameters in bulk solution using photobleaching. Biophys. J. 60: 596-610,1991.
13. Luxon, B. A. Inhibition of binding to fatty acid binding protein (FABP) reduces the intracellular transport of a fluorescent fatty acid analogue: further evidence for a transport role of FABP (Abstract). Gastroenterology 104: A946,1993.
14. Luxon, B. A., and R. A. Weisiger. Sex differences in cytoplasmic transport of a fatty acid analogue: evidence for a transport function of fatty acid binding protein (FABP) (Abstract). Hepatology 16:144A, 1992.
15. Luxon, B. A., and R. A, Weisiger. Sex differences in intracellular fatty acid transport: role of cytoplasmic binding proteins. Am. J. Physiol. 265 (Gastrointest. Liver Physiol. 28): G831-G841, 1993.
16. Nemecz, G., T. Hubbell, J. Jefferson, J. Lowe, and F. Schroeder. Interaction of fatty acids with recombinant rat intestinal and liver fatty acid-binding proteins. Arch. Biochem. Biophys. 286: 300-309,1991.
17. Ockner, R. K., J. Manning, and J. P. Kane. Fatty acid binding protein: isolation from rat liver, characterization, and immunochemical quantification. J. Biol. Chem. 257: 7872-7878,1982.
18. Paulussen, R., G. Jansen, and J. Veerkamp. Fatty acid binding capacity of cytosolic proteins of various rat tissues: effect of postnatal development, starvation, sex, clofibrate feeding and light cycle. Biochim. Biophys. Acta 877: 342-349,1986.
19. Polefka, T. G., R. A. Garrick, W. R. Redwood, N. I. Swislocki, and F. P. Chinard. Solute-excluded volumes near the Novikoff cell surface. Am. J. Physiol. 247 (Cell Physiol. 16): C350-C356,1984.
20. Qian, H., M. Sheetz, and E. Elson. Single particle tracking: analysis of diffusion and flow in two-dimensional systems. Biophys. J. 60: 910-921,1991.
21. Ralston, M. L., and R. I. Jennrich. DUD, a derivative-free algorithm for nonlinear least squares. Technometrics 20: 7-14, 1978.
22. Shields, H. M., M. L. Bates, N. M. Bass, C. J. Best, D. H. Alpers, and R. K. Ockner. Light microscopic immunocytochemical localization of hepatic and intestinal types of fatty acidbinding proteins in rat small intestine. J. Lipid Res. 27:549-557, 1986.
23. Snedecor, G. W, and W. G. Cochran. Statistical Methods. Ames, IA: Iowa State University Press, 1967, p. 84-86.
24. Sorrentino, D., W. Stremmel, and P. D. Berk. The hepatocellular uptake of bilirubin: current concepts and controversies. Mol. Aspects Med. 9:405-428,1987.
25. Stollman, Y. R., L. Theilmann, R. J. Stockert, and A. W. Wolkoff. Reduced transport of bilirubin and asialoorosomucoid in regenerating rat liver is a microtubule-independent event. Hepatology 5: 798-804,1985.
26. Storch, J. A comparison of heart and liver fatty acid-binding proteins: interactions with fatty acids and possible functional differences studied with fluorescent fatty acid analogues. Mol. Cell. Biochem. 98: 141-147,1990.
27. Storch, J., and N. M. Bass. Transfer of fluorescent fatty acids from liver and heart fatty acid-binding proteins to model membranes. J. Biol. Chem. 265: 7827-7831,1990.
28. Storch, J., N. M. Bass, and A. M. Kleinfeld. Studies of the fatty acid-binding site of rat liver fatty acid-binding protein using fluorescent fatty acids. J. Biol. Chem. 264: 8708-8713,1989.
29. Storch, J., N. M. Bass, and A. M. Kleinfeld. Studies of the fatty acid-binding site of rat liver fatty acid-binding protein using fluorescent fatty acids. J. Biol. Chem. 264: 8708-8713,1989.
30. Unterberg, C., T. Barchers, P. Hojrup, P. Roepstorff, J. Knudsen, and P. Spener. Cardiac fatty acid-binding proteins. Isolation and characterization of the mitochondrial fatty acidbinding protein and its structural relationship with the cytosolic isoforms. J. Biol. Chem. 265:16255-16261,1990.
31. Veerkamp, J., and H. Van Moerkerk. Fatty acid binding protein and its relation to fatty acid oxidation. Mol. Cell Biochem. 123:101-106,1993.
32. Yguerabide, J., J. Schmidt, and E. Yguerabide. Lateral mobility in membranes as detected by fluorescence recovery after photobleaching. Biophys. J. 39: 69-75,1982.