Dispersion optimization to enhance PHB production in fed-batch cultures of Ralstonia eutropha

Bioresource Technology

Volumn 97, Issue 16, 2006, Pages 1994-2001

  Patnaik, Pratap R ^a  

^a INSTITUTE OF MICROBIAL TECHNOLOGY   (India)

Author keywords

Fed batch fermentation; Incomplete dispersion; PHB; Ralstonia eutropha

Indexed keywords

BACTERIA; BIOREACTORS; DISPERSIONS; FERMENTATION; MATHEMATICAL MODELS; OPTIMIZATION; SYNTHESIS (CHEMICAL);

DISPERSION MODELS; FED-BATCH FERMENTATION; INCOMPLETE DISPERSION; POLY-Β-HYDROXYBUTYRATE (PHB);

ORGANIC POLYMERS;

POLY(3 HYDROXYBUTYRIC ACID);

BACTERIA; BIOREACTORS; DISPERSIONS; FERMENTATION; MATHEMATICAL MODELS; OPTIMIZATION; ORGANIC POLYMERS; SYNTHESIS (CHEMICAL);

DISPERSION; ESTER; FERMENTATION; POLYMER; REACTION KINETICS;

ARTICLE; CELL GROWTH; DISPERSION; FED BATCH REACTOR; FERMENTATION; NONHUMAN; PRIORITY JOURNAL; SYNTHESIS; WAUTERSIA EUTROPHA;

BIOPOLYMERS; BIOREACTORS; CUPRIAVIDUS NECATOR; FERMENTATION; HYDROXYBUTYRATES; KINETICS; MODELS, BIOLOGICAL; POLYESTERS;

CUPRIAVIDUS NECATOR;

EID: 33745424182     PISSN: 09608524     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biortech.2005.09.027     Document Type: Article

References (35)

1. Anderson A.J., and Dawes W.A. Occurrence, metabolism, metabolic role, and industrial uses of bacterial polyhydroxyalkanoates. Microbiol. Rev. 54 (1990) 450-472
2. Asenjo J.A., and Suk J.S. Kinetics and models for the bioconversion of methane into an intracellular polymer, poly-β-hydroxybutyrate (PHB). Biotechnol. Bioeng. Sympos. 15 (1985) 225-234
3. Babel W., Ackerman J.-U., and Breuer U. Physiology, regulation, and limits of the synthesis of poly(3HB). Adv. Biochem. Eng. Biotechnol. 71 (2001) 125-157
4. Bradford, D., 1992. Growth and Accumulation of Poly-hydroxybutyric Acid by Alcaligenes eutrophus. Honors thesis, Dept. Chem. Eng., Univ. Queensland, Australia.
5. Braunegg G., Lefebre G., and Genser K.F. Polyhydroxyalkanoates, biopolymers from renewable resources: physiological and engineering aspects. J. Biotechnol. 65 (1998) 127-161
6. Doi Y. Microbial Polyesters (1990), VCH, New York
7. Doi Y., Segawa A., Kawaguchi Y., and Kunioka M. Cyclic nature of poly(3-hudroxyalkanoate) metabolism in Alcaligenes eutrophus. FEMS Microbiol. Lett. 67 (1990) 165-170
8. Froment G.F., and Bischoff K.B. Chemical Reactor Analysis and Design (1990), John Wiley, New York (Chapter 12), pp. 509-565
9. Gregory M.O., Fernando S.-R., and Cooney C.L. Design and evaluation of control strategies for high cell density fermentation. Biotechnol. Bioeng. 39 (1992) 293-304
10. Groethe E., Moo-Young M., and Chisti Y. Fermentation optimization for the production of poly(β-hydroxybutyric acid) microbial thermoplastic. Enzyme Microb. Technol. 25 (1999) 132-141
11. Katoh T., Yuguchi D., Yoshii H., Shi H., and Shimizu K. Dynamics and modeling on fermentative production of poly(β-hydroxybutyric acid) from sugars via lactate by a mixed culture of Lactobacillus delbrueckii and Alcaligenes eutrophus. J. Biotechnol. 67 (1999) 113-134
12. Kim B.S., Lee S.C., Lee S.Y., Chang H.N., Chang Y.K., and Woo S.I. Production of poly(3-hydroxybutyric acid) by fed-batch culture of Alcaligenes eutrophus with glucose concentration control. Biotechnol. Bioeng. 43 (1994) 892-898
13. Larsson G., Tornquist M., Wernersson E.S., Tragardh C., Noorman H., and Enfors S.-O. Substrate gradients in bioreactors: origin and consequence. Bioprocess Eng. 14 (1996) 281-289
14. Lee J.H., Lim H.C., and Hong J. Application of singular transformation to on-line optimal control of poly-β-hydroxybutyrate fermentation. J. Biotechnol. 55 (1997) 135-150
15. Lee S.Y., and Chang H.N. Production of poly(hydroxyalkanoic acid). Adv. Biochem. Eng. Biotechnol. 52 (1995) 27-58
16. Lemoigne M. Etudes sur l'autolyse microbienne origine de l'acide β-oxybutyrique forme par autolyse. Ann. Inst. Pasteur 41 (1927) 148-165
17. Leudking R., and Piret E.L. A kinetic study of the lactic acid fermentation. J. Biochem. Microb. Technol. Eng. 1 (1959) 393-431
18. Liden G. Understanding the bioreactor. Bioprocess Biosyst. Eng. 24 (2001) 273-279
19. Luong J.H.T. Generalization of Monod kinetics for analysis of growth data with substrate inhibition. Biotechnol. Bioeng. 29 (1987) 242-248
20. Macrae R.M., and Wilkinson J.F. The influence of culture conditions of poly-β-hydroxybutyrate synthesis by Bacillus megaterium. Proc. Roy. Phys. Soc. Edin. 27 (1958) 73-78
21. Montague G.A., and Ward A.C. A suboptimal solution to optimization of bioreactors using the chemotaxis algorithm. Process Biochem. 29 (1994) 489-496
22. Mulchandani A., Luong J.H.T., and Groom C. Substrate inhibition kinetics for microbial growth and synthesis of poly-β-hydroxybutyric acid. Appl. Microb. Biotechnol. 30 (1989) 11-17
23. Patnaik P.R. A heuristic approach to fed-batch optimization of streptokinase fermentation. Bioprocess Eng. 13 (1995) 109-112
24. Patnaik P.R. Incomplete mixing in large bioreactors-a study of its role in the fermentative production of streptokinase. Bioprocess Eng. 14 (1996) 91-96
25. Patnaik P.R. Improvement of the microbial production of streptokinase by controlled filtering of process noise. Process Biochem. 35 (1999) 309-315
26. Patnaik P.R. Enhancement of protein activity in a recombinant fermentation by optimizing fluid dispersion and initial plasmid copy number dispersion. Biochem. Eng. 9 (2001) 111-118
27. Patnaik P.R. Effect of fluid dispersion on cybernetic control of microbial growth on substitutable substrate. Bioprocess Biosyst. Eng. 25 (2003) 315-321
28. Patwardhan P.R., and Srivastava A.K. Model-based fed-batch cultivation of R. eutropha for enhanced biopolymer production. Biochem. Eng. J. 20 (2004) 21-28
29. Riascos C.A.M., and Pinto J.M. Optimal control bioreactors: a simultaneous approach for complex systems. Chem. Eng. J. 99 (2004) 33-34
30. Shahhosseini S. Simulation and optimization of PHB production in fed-batch culture of Ralstonia eutropha. Process Biochem. 39 (2004) 963-969
31. Steinbuchel A. PHB and other polyhydroxyalkanoic acids. In: Rehm H.-J., and Reed G. (Eds). Biotechnology vol. 6 (1996), VCH, Weinheim 403-464 (Chapter 13)
32. Tavares L.Z., da Silva E.S., and da Cruz Pradella J.G. Production of poly(3-hydroxybutyrate) in an airlift bioreactor by Ralstonia eutropha. Biochem. Eng. J. 18 (2004) 21-31
33. Tohyama M., and Shimizu K. Control of a mixed culture of Lactobacillus delbrueckii and Ralstonia eutropha for the production of PHB from glucose via lactate. Biochem. Eng. J. 4 (1999) 45-53
34. Tohyama M., Takagi S., and Shimizu K. Effect of controlling lactate concentration and periodic change in DO concentration on fermentation characteristics of a mixed culture of Lactobacillus delbueckii and Ralstonia eutropha for PHB production. J. Biosci. Bioeng. 89 (2000) 323-328
35. Wang J., and Yu J. Kinetic analysis on formation of poly(3-hydroxybutyrate) from acetic acid by Ralstonia eutropha under chemically defined conditions. J. Ind. Microbiol. Biotechnol. 26 (2001) 121-126