Pentagastrin-induced protein synthesis in the parotid gland of the anaesthetized rat, and its dependence on CCK-A and -B receptors and nitric oxide generation

Experimental Physiology

Volumn 91, Issue 4, 2006, Pages 673-679

  Aras, Hülya Çevik ^a   Ekstrom J ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR; CHOLECYSTOKININ A RECEPTOR; CHOLECYSTOKININ A RECEPTOR ANTAGONIST; CHOLECYSTOKININ B RECEPTOR; CHOLECYSTOKININ B RECEPTOR ANTAGONIST; ITRIGLUMIDE; LEUCINE; LORGLUMIDE; MUSCARINIC RECEPTOR; N OMEGA PROPYLARGININE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; PENTAGASTRIN; PENTOBARBITAL; TRICHLOROACETIC ACID; UNCLASSIFIED DRUG;

ADOLESCENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; NONHUMAN; PAROTID GLAND; PHARMACOLOGICAL BLOCKING; PROTEIN CONTENT; PROTEIN SYNTHESIS; RAT; RECEPTOR BLOCKING;

EID: 33745392313     PISSN: 09580670     EISSN: 1469445X     Source Type: Journal    
DOI: 10.1113/expphysiol.2006.033639     Document Type: Article

References (27)

1. Axelson A Fan BG Ohlsson B Rehfeld J Ekelund M & Ihse I ( 1996). The changes in the rat parotid glands following total parenteral nutrition and pancreatico-biliary diversion are not mediated by cholecystokinin. Int J Pancreatol 20, 109 118.
2. Ballabeni V Calcina F Bosetti M Chiavarani M Bertoni S Impicciatore M & Barocelli E ( 2002). Different role of the histamine H3-receptor in vagal, betanechol-, pentagastrin-induced gastric acid secretion in anaesthetized rats. Scand J Gastroenterol 37, 754 758.
3. Çevik Aras H & Ekström J ( 2006). Cholecystokinin- and gastrin-induced protein and amylase secretion from the parotid gland of the anaesthetized rat. Regul Pept DOI :.
4. B/gastrin receptor is coupled to the regulation of enzyme secretion, protein synthesis and p70, S6 kinase activity in acinar cells from ElasCCKB transgenic mice. Eur J Biochem 266, 1003 1010.
5. Ekström J Ekman R Håkanson R Sjögren S & Sundler F ( 1988). Calcitonin gene-related peptide in rat salivary glands: neuronal localization, depletion upon nerve stimulation, and effects on salivation in relation to substance P. Neuroscience 26, 933 949.
6. Ekström J Engdal Havel G & Reinhold A-C ( 2000). Parasympathetic non-adrenergic, non-cholinergic-induced protein synthesis and mitogenic activity in rat parotid glands. Exp Physiol 85, 171 176.
7. Ekström J Helander HF & Tobin G ( 1993). Parasympathetic non-adrenergic non-cholinergic mechanisms in reflex secretion of parotid acinar granules in conscious rats. J Physiol 472, 233 244.
8. Ekström J & Reinhold AC ( 2001). Reflex-elicited increases in female rat parotid protein synthesis involving parasympathetic non-adrenergic, non-cholinergic mechanisms. Exp Physiol 86, 605 610.
9. Grand RJ & Gross PR ( 1969). Independent stimulation of secretion and protein synthesis in rat parotid gland. The influence of epinephrine and dibutyryl cyclic adenosine 3′,5′-monophosphate. J Biol Chem 244, 5608 5615.
10. Johnson D & Sreebny LM ( 1973). Effect of isoproterenol on synthesis and secretion in the rat parotid gland. Lab Invest 28, 263 269.
11. Khosravani N Sandberg M & Ekström J ( 2006). The otic ganglion and its parotid connection in the rat: cholinergic pathways, reflex secretion and a secretory role for the facial nerve. Exp Physiol 91, 239 247.
12. Kitano M Norlén P & Håkanson R ( 2000). Gastric submucousal microdialysis: a method to study gastrin- and food-evoked mobilization of ECL-cell histamine in conscious rats. Regul Pept 86, 113 123.
13. Liddle RA Goldfine ID & Williams JA ( 1984). Bioassay of plasma cholecystokinin in rats: effects of food, trypsin inhibitor, and alcohol. Gastroenterology 87, 542 549.
14. Makovec F Bani M Cereda R Chiste R Pacini MA Revel L Rovati LA Rovati LC & Setnikar I ( 1987). Pharmacological properties of lorglumide as a member of a new class of cholecystokinin antagonists. Arzneimittelforschung 37, 1265 1268.
15. B receptor antagonist. Eur J Pharmacol 369, 81 90.
16. Månsson B Nilsson BO & Ekström J ( 1990). Effects of repeated infusions of substance P and vasoactive intestinal peptide on the weights of salivary glands subjected to atrophying influences in rats. Br J Pharmacol 101, 853 858.
17. Maystone PD & Barrowman JA ( 1971). The influence of chronic adminstration of pentagastrin on the rat pancreas. Q J Exp Physiol 56, 113 122.
18. Moncada S ( 1992). The 1991 Ulf von Euler Lecture. The l-arginine: nitric oxide pathway. Acta Physiol Scand 145, 201 227.
19. Pradel P Estival A Seva C Wicker-Planquart C Puigserver A Vaysse N & Clemente F ( 1993). Caerulein and gastrin (2-17ds) regulate differently synthesis of secretory enzymes, mRNA levels and cell proliferation in pancreatic acinar cells (AR4-2J). Biochem J 290, 219 224.
20. Qader SS Salehi A Håkanson R Lundquist I & Ekelund M ( 2005). Long-term infusion of nutrients (total parenteral nutrition) suppresses circulating ghrelin in food-deprived rats. Regul Pept 131, 82 88.
21. Rehfeld JF ( 2004). Cholecystokinin. Best Pract Clin Endocrin Metabol 18, 569 586.
22. Sayardoust S & Ekström J ( 2003). Nitric oxide-dependent in vitrosecretion of amylase from innervated or chronically denervated parotid glands of the rat in response to isoprenaline and vasoactive intestinal peptide. Exp Physiol 88, 381 387.
23. Sayardoust S & Ekström J ( 2004). Nitric oxide-dependent protein synthesis in parotid and submandiblular glands of anaesthetized rats upon sympathetic stimulation or isoprenaline administration. Exp Physiol 89, 219 227.
24. Sayardoust S & Ekström J ( 2006). Parasympathetic nerve-evoked protein synthesis, mitotic activity and salivary secretion in the rat parotid gland and the dependence on NO-generation. Arch Oral Biol 51, 189 197.
25. Sreebny LM Johnson DA & Robinovitch MR ( 1971). Functional regulation of protein synthesis in the rat parotid gland. J Biol Chem 246, 3879 3884.
26. Williams JA ( 2001). Intracellular signal mechanisms activated by cholecystokinin-regulating synthesis and secretion of digestive enzymes in pancreatic acinar cells. Annu Rev Physiol 63, 77 97.
27. ω-propyl-l-arginine. J Med Chem 40, 3869 3870.