Cardiovascular effects of microinjection of low doses of serotonin into the NTS of unanesthetized rats

American Journal of Physiology

Volumn 272, Issue 4 PART 2, 1997, Pages

  Callera, Joäo Carlos ^a   Bonagamba, Leni G H ^a   Sévoz, Caroline ^a,b   Laguzzi, Raul ^a,b   Machado, Benedito H ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

Author keywords

Arterial baroreceptors; Autonomie nervous system; Heart rate; Peripheral chemoreceptors; Serotonin receptors

Indexed keywords

EID: 33745390752     PISSN: 00029513     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Bhaskaran, D., and C. R. Freed. Changes in arterial pressure lead to baroreceptor mediated changes in norepinephrine and 5-hydroxy-indolacetic acid in the rat nucleus tractus solitarius. J. Pharmacol. Exp. Ther. 245: 356-363, 1988.
2. Carter, D. A., and S. L. Lightnian. Cardio-respiratory actions of substance P, TRH and 5-HT in the nucleus tractus solitarius of rats: evidence for functional interactions of neuropeptides and amine neurotransmitters. Neuropeptides 6: 424-436, 1985.
3. Chalmers, J. P., and L. M. H. Wing. Central serotonin and cardiovascular control. Clin. Exp. Pharmacol. Physiol. 2: 195200,1975.
4. Colombari, E., L. G. H. Bonagamba, and B. H. Machado. Mechanisms of pressor and bradycardic responses to L-glutamate microinjected into the nucleus tractus solitarii of conscious rats. Am. J. Physiol 266 (Regulatory Integrative Comp. Physiol. 35): R730-R738,1994.
5. Franchini, K. G., and E. M. Krieger. Cardiovascular responses of conscious rats to carotid body chemoreceptor stimulation by intravenous KCN. J. Auton. Nerv. Syst. 42: 63-70, 1993.
6. Fuxe, K. Evidence for existence of monoamine containing neurons in the central nervous system. Distribution of monoamine nerve terminals in the central nervous system. Acta Physiol. Scared. 64, Suppl. 247: 1-84,1965.
7. Gordon, F. J., and W. T. Talman. Role of excitatory amino acids and their receptors in bulbospinal control of cardiovascular function. In: Central Neural Mechanisms in Cardiovascular Regulation, edited by G. Kunos and J. Ciriello. Boston, MA: Birkauser, 1992, vol. 2, p. 209-225.
8. Itoh, H., and R. D. Bunäg. Cardiovascular and sympathetic effects of injecting serotonin in the nucleus tractus solitarius in rats. J. Pharmacol. Exp. Ther. 256: 1147-1153, 1991.
9. Laguzzi, R., D. J. Reis, and W. T. Talman. Modulation of cardiovascular and electrocortical activity through serotonergic mechanisms in the nucleus tractus solitarius of the rat. Brain Res. 304: 321-328, 1984.
10. Machado, B. H., and L. G. H. Bonagamba. Microinjection of L-glutamate into the nucleus tractus solitarii increases arterial pressure in conscious rats. Brain Res. 576: 131-138, 1992.
11. Maley, B. E., and R. P. Eide. The ultrastructural localization of serotonin immunoreactivity within the nucleus of the solitary tract of the cat. J. Neurosci. 2:1499-1506, 1982.
12. Merahi, N., H. S. Orer, and R. Laguzzi. 5-HT2 receptors in the nucleus tractus solitarius: characterization and role in the cardiovascular regulation in the rat. Brain Res. 575: 74-78, 1992.
13. 3 receptors in the nucleus tractus solitarius of the rat. Neuroscience 46: 91-100, 1992.
14. Michelini, L. C., and L. G. H. Bonagamba. Baroreceptor reflex modulation by vasopressin microinjected into the nucleus tractus solitarii of conscious rats. Hypertension 11, SuppL I: 175-179, 1988.
15. Nosjean, A., C. Compoint, C. Buisseret-Delmas, H. S. Orer, N. Merahi, J.-J. Puizikkout, and R. Laguzzi. Serotonergic projections from the nodose ganglia to the nucleus tractus solitarius: an immunohistochemical and double labeling study in the rat. Neurosci. Lett. 114: 22-26, 1990.
16. Nosjean, A., B. Franc, and R. Laguzzi. Increased sympathetic nerve discharge without alteration in the sympathetic baroreflex response by serotonins receptor stimulation in the nucleus tractus solitarius of the rat. Neurosci. Lett. 186: 41-44, 1995.
17. Orer, H. S., N. Merahi, A. Nosjean, C. M. Fattaccini, and R. Laguzzi. Effects of the local injection of 5,7-dihydroxytryptamine into the nodose ganglia and nucleus tractus solitarius in awake freely moving rats. Brain Res. 553: 123-128, 1991.
18. Paxinos, G., and C. Watson. The Rat Brain in Stereotaxic Coordinates. New York: Academic, 1986.
19. Sévoz, C., A. Nosjean, J. C. Callera, B. H. Machado, M. Hamon, and R. Laguzzi. Stimulation of serotonin3 receptors in the nucleus tractus solitarius inhibits the cardiac Bezold-Jarisch reflex response. Am. J. Physiol. 271 (Heart Circ. Physiol. 40): H80-H87, 1996.
20. Shvaloff, A., and R. Laguzzi. Serotonin receptors in the rat nucleus tractus solitarii and cardiovascular regulation. Ear. J. Pharmacol. 132: 283-288, 1986.
21. Spyer, K. M., P. N. Izzo, R. J. Lin, J. F. R. Paton, L. F. Silva-Carvalho, and D. W. Richter. The central nervous organization of the carotid body chemoreceptor reflex. In: Chemoreceptors and Chemoreceptors Reflex, edited by H. Acker, A. Trzebski, and D. O'Regan. New York: Plenum, 1990, p. 317-321.
22. Steinbusch, H. W. M. Distribution of serotonin-immunoreactivity in the central nervous system of the rat cell bodies and terminals. Neuroscience 6: 557-618, 1981.
23. Steinbusch, H. W. M. Serotonin-immunoreactive neurons and their projections in the CNS. In: Handbook of Chemical Anatomy, edited by A. Bjorklund, T. Hokfelt, and M. J. Kuhar. Amsterdam: Elsevier, 1984, vol. 3, p. 68-125.
24. Talman, W. T., M. H. Perrone, and D. J. Reis. Evidence for L-glutamate as the neurotransmitter of the baroreceptors afferent nerve fibers. Science 209: 813-815,1980.
25. Vardhan, A., A. Kachroo, and H. N. Sapru. Excitatory amino acid receptors in commissural nucleus of the NTS mediate carotid chemoreceptor responses. Am. J. Physiol. 264 (Regulatory Integrative Comp. Physiol. 33): R41-R50, 1993.
26. Wolf, W. A., D. M. Kühn, and W. Lovenberg. Blood pressure responses to local application of serotonergic agents in the nucleus tractus solitarii. Eur. J. Pharmacol. 69: 291-299, 1981.
27. Zhang, W., and S. W. Mifflin. Excitatory amino acid receptors within the NTS mediate arterial chemoreceptor reflexes in rats. Am. J. Physiol. 265 (Heart Circ. Physiol. 34): H770-H773, 1993.