Mifepristone (RU38486) influences the core temperature response of term pregnant rats to intraperitoneal lipopolysaccharide

Experimental Physiology

Volumn 91, Issue 4, 2006, Pages 741-746

  Moore, Sherry L ^a   Fewell, James E ^a  

^a UNIVERSITY OF CALGARY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; CORTICOSTERONE; CYTOKINE; ENDOTOXIN; GLUCOCORTICOID RECEPTOR ANTAGONIST; MIFEPRISTONE; PROSTANOID;

ARTICLE; BASAL BODY TEMPERATURE; CONTROLLED STUDY; CORE TEMPERATURE; CORTICOSTERONE BLOOD LEVEL; ESCHERICHIA COLI; FEMALE; FEVER; HORMONAL REGULATION; HYPOTHERMIA; INFECTION; NONHUMAN; PREGNANCY; RAT; THERMOREGULATION;

EID: 33745385102     PISSN: 09580670     EISSN: 1469445X     Source Type: Journal    
DOI: 10.1113/expphysiol.2006.033688     Document Type: Article

References (41)

1. Atkinson HC & Waddell BJ ( 1995). The hypothalamic-pituitary-adrenal axis in rat pregnancy and lactation: circadian variation and interrelationship of plasma adrenocorticotropin and corticosterone. Endocrinology 136, 512 520.
2. Besedovsky H Del Rey A Sorkin E & Dinarello CA ( 1986). Immunoregulatory feedback between interleukin-1 and glucocorticoid hormones. Science 233, 652 654.
3. Besedovsky H Sorkin E Keller M & Muller J ( 1975). Changes in blood hormone levels during the immune response. Proc Soc Exp Biol Med 150, 466 470.
4. Beutler B & Cerami A ( 1986). Cachectin and tumour necrosis factor as two sides of the same biological coin. Nature 320, 584 588.
5. Brunton PJ Meddle SL Ma S Ochedalski T Douglas AJ & Russell JA ( 2005). Endogenous opioids and attenuated hypothalamic-pituitary-adrenal axis responses to immune challenge in pregnant rats. J Neurosci 25, 5117 5126.
6. Buller KM Xu Y Dayas CV & Day TA ( 2001). Dorsal and ventral medullary catecholamine cell groups contribute differentially to systemic interleukin-1β-induced HPA axis responses. Neuroendocrinology 73, 129 138.
7. Coelho MM Souza GEP & Pela IR ( 1992). Endotoxin-induced fever is modulated by endogenous glucocorticoids in rats. Am J Physiol 263, R423 R427.
8. Deraedt R Bonnat C Busigny M Chatelet P Cousty C Mouren M Philibert D Pottier J & Salmon J ( 2003). Pharmacokinetics of RU 486. In The Antiprogestin Steroid RU 486 and Human Fertility Control, ed. Baulieu EE & Segal SJ, pp. 103 122. Plenum, New York.
9. Dupouy JP Coffigny H & Magre S ( 1975). Maternal and fetal corticosterone levels during late pregnancy in rats. J Endocrinol 65, 347 352.
10. Dymond KE & Fewell JE ( 1998). Coordination of autonomic and behavioral thermoregulatory responses during exposure to a novel stimulus in rats. Am J Physiol 275, R673 R676.
11. Eliason HL & Fewell JE ( 1997). Thermoregulatory control during pregnancy and lactation in rats. J Appl Physiol 83, 837 844.
12. Ericsson A Kovacs KJ & Sawchenko PE ( 1994). A functional anatomical analysis of central pathways subserving the effects of interleukin-1 on stress-related neuroendocrine neurons. J Neurosci 14, 897 913.
13. Ericsson A Liu C Hart RP & Sawchenko PE ( 1995). Type 1 interleukin-1 receptor in the rat brain: distribution, regulation, and relationship to sites of IL-1-induced cellular activation. J Comp Neurol 361, 681 698.
14. Fewell JE Eliason HL & Auer RN ( 2002). Peri-OVLT E-series prostaglandins and core temperature do not increase following intravenous IL-1β in pregnant rats. J Appl Physiol 93, 531 536.
15. Fofie AE & Fewell JE ( 2003). Influence of pregnancy on plasma cytokines and the febrile response to intraperitoneal administration of bacterial endotoxin in rats. Exp Physiol 88, 747 754.
16. Fofie AE Fewell JE & Moore SL ( 2005). Pregnancy influences the plasma cytokine response to intraperitoneal administration of bacterial endotoxin in rats. Exp Physiol 90, 95 101.
17. Freeman ME Crissman JK Louw GN Butcher RL & Inskeep EK ( 1970). Thermogenic action of progesterone in the rat. Endocrinology 86, 717 720.
18. Gagne D Pons M & Philibert D ( 1985). RU 38486: a potent antiglucocorticoid in vitro and in vivo. J Steroid Biochem 23, 247 251.
19. Givalois L Siaud P Mekaouche M Ixart G Malaval F Assenmacher I & Barbanel G ( 1995). Early hypothalamic activation of combined Fos and CRH41 immunoreactivity and of CRH41 release in push-pull cannulated rats after systemic endotoxin challenge. Mol Cel Neuropathol 26, 171 186.
20. Hardwick AJ Linton EA & Rothwell NJ ( 1989). Thermogenic effects of the antiglucorticoid RU-486 in the rat: involvement of corticotrophin-releasing factor and sympathetic activation of brown adipose tissue. Endocrinology 124, 1684 1688.
21. 2inhibitory protein in rabbit neutrophils induced by glucocorticoids. Proc Natl Acad Sci U S A 77, 2533 2536.
22. 2. Am J Physiol Regul Integr Comp Physiol 283, R1346 R1353.
23. Johnstone HA Wigger A Douglas AJ Neumann ID Landgraf R Seckl JR & Russell JA ( 2000). Attenuation of hypothlamic-pituitary-adrenal axis stress responses in late pregnancy: changes in feedforward and feedback mechanisms. J Neuroendocrinol 12, 811 822.
24. Kakucska I Qi Y Clark BD & Lechan RM ( 1993). Endotoxin-induced corticotropin-releasing hormone gene expression in the hypothalamic paraventricular nucleus is mediated centrally by interleukin-1. Endocrinology 133, 815 821.
25. Martin SM Malkinson TJ Veale WL & Pittman QJ ( 1995). Fever in pregnant, parturient, and lactating rats. Am J Physiol 268, R919 R923.
26. Milton AS & Wendlandt S ( 1970). A possible role for prostaglandin E1 as a modulator for temperature regulation in the central nervous system of the cat. J Physiol 207, 76P 77P.
27. Morishige WK Pepe GJ & Rothchild I ( 1973). Serum luteinizing hormone, prolactin and progesterone levels during pregnancy in the rat. Endocrinology 92, 1527 1530.
28. Morrow LE McClellan JL Conn CA & Kluger MJ ( 1993). Glucocorticoids alter fever and IL-6 responses to psychological stress and to lipopolysaccharide. Am J Physiol 264, R1010 R1016.
29. Nakayama T Suzuki M & Ishizuka N ( 1975). Action of progesterone on preoptic thermosensitive neurones. Nature 258, 80.
30. Neumann ID Johnstone HA Hatzinger M Liebsch G Shipston M Russell JA Landgraf R & Douglas AJ ( 1998). Attenuated neuroendocrine responses to emotional and physical stressors in pregnant rats involve adenohypophysial changes. J Physiol 508, 289 300.
31. 2and cyclooxygenase-2 mRNA is suppressed by glucocorticoids in human epithelial cells. Life Sci 60, 67 78.
32. Pepe GJ & Rothchild I ( 1974). A comparative study of serum progesterone levels in pregnancy and various types of pseudopregnancy in the rat. Endocrinology 95, 275 279.
33. Philibert D ( 1984). RU38486: an original multifaceted antihormone in vivo. In Adrenal Steroid Antagonism, ed. Agarwal MJ, pp. 77 101. Gruyer, Berlin.
34. Rivest S Lacroix S Vallieres L Nadeau S Zhang J & Laflamme N ( 2000). How the blood talks to the brain parenchyma and the paraventricular nucleus of the hypothalamus during systemic inflammatory and infectious stimuli. Exp Biol Med 223, 22 38.
35. Simrose RL & Fewell JE ( 1995). Body temperature response to IL-1β in pregnant rats. Am J Physiol 38, R1179 R1182.
36. Smith FG Fewell JE & Abu-Amarah I ( 1997). Endocrine effects of pregnancy and exposure to a simulated open field in rats. Am J Physiol 273, R1053 R1057.
37. Snyder DS & Unanue ER ( 1982). Corticosteroids inhibit murine macrophage 1a expression and interleukin 1 production. J Immunol 129, 1803 1805.
38. Stobie-Hayes KM & Fewell JE ( 1996). Influence of pregnancy on the febrile response to intracerebroventricular administration of PGE1 in rats. J Appl Physiol 81, 1312 1315.
39. Turnbull AV Lee S & Rivier C ( 1998). Mechanisms of hypothalamic-pituitary-adrenal axis stimulation by immune signals in the adult rat. Ann N Y Acad Sci 840, 434 443.
40. Waddell BJ & Atkinson HC ( 1994). Production rate, metabolic clearance rate and uterine extraction of corticosterone during rat pregnancy. J Endocrinol 143, 183 190.
41. Zhang J & Rivest S ( 1999). Distribution, regulation and colocalization of the genes encoding the EP2- and EP4-PGE2 receptors in the rat brain and neuronal responses to systemic inflammation. Eur J Neurosci 11, 2651 2688.