Human connexin 43 gap junction channel gating: Evidence for mode shifts and/or heterogeneity

American Journal of Physiology

Volumn 271, Issue 1 PART 1, 1996, Pages

  Brink, P R ^a,b   Ramanan, S V ^a,b   Christ, G J ^a,b  

^a STONY BROOK UNIVERSITY   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Mean closed time; Mean open time; Voltage dependent mode shifting

Indexed keywords

EID: 33745343125     PISSN: 00029513     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Alder, H. L., and E. B. Roessler. Introduction to Probability and Statistics (3rd ed.). San Fransisco, CA: W. H. Freeman and Company, 1964, p. 313.
2. Brink, P. R. Gap junction channels and cell-to-cell messengers in myocardium. J. Cardiovasc. Electrophysiol. 2: 360-366, 1991.
3. Burt, J. M., and D. C. Spray. Inotropic agents modulate gap junctional conductance between cardiac myocytes. Am. J. Physiol. 254 (Heart Circ. Physiol. 23): H1206-H1210,1988.
4. Chanson, M., K. J. Chansdross, M. B. Rook, J. A. Kessler, and D. C. Spray. Gating characteristics of a Steeply voltagedependent gap junction channel in rat schwaan cells. J. Gen. Physiol. 102: 925-946,1993.
5. Christ, G., P. R. Brink, and S. V. Ramanan. Dynamic gap junctional communication: a delimiting model for tissue responses. Biophys. J. 67:1335-1344,1994.
6. Christ, G., P. R. Brink, W. Zhao, J. Moss, C. M. Gondre, C. Roy, and D. C. Spray. Gap junctions modulate agonist efficacy during activation of the al-adrenergic receptor by phenylephrine and oxymethazoline in isolated rat aorta. J. Pharmacol. Exp. Ther. 266: 1054-1065, 1993.
7. 2+ in cultured human corporal smooth muscle cells. Am. J. Physiol. 263 (Cell Physiol. 32): C373-C383,1992.
8. Colquhoun, D., and F. J. Sigworth. Fitting and statistical analysis of single channel records. In: Single Channel Recording, edited by B. Sakmann and E. Neher. New York: Plenum, 1983, p. 191-263.
9. Dabrowski, A. R., and D. McDonald. Statistical analysis of mutliple ion channel data. Ann. Stat. 20: 1180-1202,1992.
10. Goodenough, D. A. The structure and permeability of isolated hepatocyte gap junctions. Cold Spring Harbor Symp. Quant. Biol. 15: 37-44,1975.
11. Harris, A., D. C. Spray, and M. V. L. Bennett. Kinetic properties of a voltage dependent junctional conductance. J. Gen. Physiol. 77: 95-117,1981.
12. Herzig, S., P. Patil, J. Neumann, C. Staschen, and D. T. Yue. Mechanisms of beta-adrenergic stimulation of Ca channels revealed by discrete-time Markov analysis of slow gating. Biophys. J. 65:1599-1612,1993.
13. Hess, P., B. Lansman, and R. W. Tsien. Different modes of Ca channel gating behaviour favored by dihydropyridine Ca agonists and antagonists. Nature Land. 311: 538-544,1984.
14. Kensler, R. W., P. R. Brink, and M. M Dewey. The nexus of the frog ventricle. J. Cell Biol. 73: 768-781,1977.
15. Manivannan, K, S. V. Ramanan, R. T. Mathias, and P. R. Brink. Multichannel recordings from membranes which contain gap junctions. Biophys. J. 61: 216-227,1992.
16. 2+ activated K+ channels in rat skeletal muscle. J. Physiol. Land. 443: 739-777,1984.
17. Moreno, A. P., A. C. Campos De Carvoalho, G. Christ, A. Melman, and D. C. Spray. Gap junctions between corpus carvarnosum smooth muscle cells: gating properties and unitary conductance. Am. J. Physiol. 264 (Cell Physiol. 33): C80-C92,1993.
18. Moreno, A. P., W. Saez, G. I. Fishman, and D. C. Spray. Human connexin 43 gap junction channels: regulation of unitary conductance by phosphylation. Circ. Res. 74: 1015-1058,1994.
19. Neyton, J., and A. Trautmann. Single channel currents of an intercellular junction. Nature Lond. 317: 331-335,1985.
20. Press, W. H., B. P. Flannery, S. A. Teukolsky, and W. T. Vetterling. Numerical Recipes. Cambridge, MA: Cambridge Univ. Press, 1988, p. 818.
21. Ramanan, S. V., and P. R. Brink. Multichannel recordings from membranes which contain gap junctions. II. Substates and conductance shifts. Biophys. J. 65:1387-1395,1993.
22. Ramanan, S. V., S. F. Fan, and P. R. Brink. Model invariant method for extracting single-channel mean open and closed times from heterogeneous multichannel records. J. Neurosci. Methods 42: 91-103,1992.
23. Ramanan, S. V., V. Mesimeris, and P. R, Brink. Ion flow in the bath and flux interactions between channels. Biophys. J. 66: 989-995,1994.
24. Sachs, F., J. Neil, and N. Barkakati. The automatic analysis of data from single ionic channels. Pfluegers Arch. 395: 331-340, 1982.
25. Takens-Kwak, B. R., and H. J. Jongsma. Cardiac gap junctions: three distinct single channel conductances and their modulation by phosphorylating treatments. Pfluegers Arch. 422: 198-200,1992.
26. Takens-Kwak, B. R., H. J. Jongsma, M. B. Rook, and A. C. G. van Ginneken. Mechanism of heptanol-induced uncoupling of cardiac gap junctions: a perforated patch-clamp study. Am. J. Physiol. 262 (Cell Physiol. 31): C1531-C1538,1992.
27. Tsien, R., and R. Weingart. Inotropic effect of cAMP in calf ventricular muscle studied by a cut end method. J. Physiol. Land. 260:117-141,1976.
28. Veenstra, R. D., and R. L. DeHaan. Measurement of single channel currents from cardiac gap junctions. Science Wash. DC 233: 972-974,1986.
29. Veenstra, R. D., Z. Wang, E. C. Beyer, and P. R. Brink. Selective dye and ionic permeability of gap junction channels formed by connexin45 channels. Circ. Res. 268: 706-712,1994.
30. Veenstra, R. D., Z. Wang, E. C. Beyer, S. V. Ramanan, and P. R. Brink. Connexin37 forms high conductance gap junction channels with subconductance state activity and selective dye and ionic permeabilities. Biophys. J. 66: 1915-1928, 1994.
31. Wang, Z., J. Li, L. F. Lemanski, and R. D. Veenstra. Gating of mammalian cardiac gap junction channels by transjunctional voltage. Biophys. J. 63:139-151,1992.
32. Wilders, B., and H. J. Jongsma. Limitations of the dual voltage clamp method in assaying conductance and kinetics of gap junctions channels. Biophys. J. 63: 942-953,1992.