Malignancy-associated venous thrombosis with concurrent warfarin-induced skin necrosis, venous limb gangrene and thrombotic microangiopathy

Thrombosis and Haemostasis

Volumn 95, Issue 6, 2006, Pages 1038-1039

  Ng, Heng Joo ^a,b   Crowther, Mark A ^c  

^a ST JOSEPH S HOSPITAL   (Canada)

^b SINGAPORE GENERAL HOSPITAL   (Singapore)

^c MCMASTER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

DALTEPARIN; HEPARIN; LOW MOLECULAR WEIGHT HEPARIN; VITAMIN K GROUP; WARFARIN;

ADENOCARCINOMA; ADULT; ARTICLE; BLOOD ANALYSIS; CASE REPORT; COMPUTER ASSISTED TOMOGRAPHY; DRUG DOSE REGIMEN; DRUG WITHDRAWAL; FEMALE; HOSPITAL DISCHARGE; HUMAN; HUMAN CELL; HUMAN TISSUE; INTERNATIONAL NORMALIZED RATIO; LABORATORY TEST; LYMPH NODE BIOPSY; NAUSEA; OLIGURIA; PARTIAL THROMBOPLASTIN TIME; PRIORITY JOURNAL; SKIN NECROSIS; THROMBOTIC THROMBOCYTOPENIC PURPURA; TOE GANGRENE; VEIN THROMBOSIS; VOMITING;

ANTICOAGULANTS; CARCINOMA, SIGNET RING CELL; FEMALE; GANGRENE; HEPARIN, LOW-MOLECULAR-WEIGHT; HUMANS; LOWER EXTREMITY; LYMPHATIC METASTASIS; MIDDLE AGED; NECROSIS; NEOPLASMS, UNKNOWN PRIMARY; PURPURA, THROMBOTIC THROMBOCYTOPENIC; SKIN; VENOUS THROMBOSIS; WARFARIN;

EID: 33745316584     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH06-03-0129     Document Type: Article

References (10)

1. Rickles FR, Edwards RL. Activation of blood coagulation in cancer: Trousseau's syndrome revisited. Blood 1983; 62: 14-31.
2. Levine MN, Lee AY, Kakkar AK. From Trousseau to targeted therapy: new insights and innovations in thrombosis and cancer. J Thromb Haemost 2003; 1: 1456-63.
3. Prandoni P, Lensing AW, Buller HR, et al. Deep-vein thrombosis and the incidence of subsequent symptomatic cancer. N Engl J Med 1992; 327: 1128-33.
4. Falanga A. Thrombophilia in cancer. Semin Thromb Hemost 2005; 31: 104-10.
5. Rickles FR, Patierno S, Fernandez PM. Tissue factor, thrombin, and cancer. Chest 2003; 124: 58S-68S.
6. Warkentin TE. Venous limb gangrene during warfarin treatment of cancer-associated deep venous thrombosis. Ann Intern Med 2001; 135: 589-93.
7. Warkentin TE, Whitlock RP, Teoh KH. Warfarin-associated multiple digital necrosis complicating heparin-induced thrombocytopenia and Raynaud's phenomenon after aortic valve replacement for adenocarcinoma-associated thrombotic endocarditis. Am J Hematol 2004; 75: 56-62.
8. Gordon LI, Kwaan HC. Thrombotic microangiopathy manifesting as thrombotic thrombocytopenic purpura/hemolytic uremic syndrome in the cancer patient. Semin Thromb Hemost 1999; 25: 217-21.
9. Fontana S, Gerritsen HE, Kremer Hovinga J, et al. Microangiopathic haemolytic anaemia in metastasizing malignant tumours is not associated with a severe deficiency of the von Willebrand factor-cleaving protease. Br J Haematol 2001; 113: 100-2.
10. Lee AY, Levine MN, Baker RI, et al. Low-molecular-weight heparin versus a coumarin for the prevention of recurrent venous thromboembolism in patients with cancer. N Engl J Med 2003; 349: 146-53.