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Erythropoietin: Physiology and pharmacology update
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Erythropoietin receptor expression in adult rat cardiomyocytes is associated with an acute cardioprotective effect for recombinant erythropoietin during ischemia-reperfusion injury
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Erythropoietin just before reperfusion reduces both lethal arrhythmias and infarct size via the phosphatidylinositol-3 kinase-dependent pathway in canine hearts
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Recombinant human erythropoietin protects the myocardium from ischemia reperfusion injury and promotes beneficial remodeling
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U S A
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Erythropoietin is a potent physiologic stimulus for endothelial progenitor cell mobilization
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Endothelial progenitor cell proliferation and differentiation is regulated by erythropoietin
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Erythropoietin enhances neovascularization of ischemic myocardium and improves left ventricular dysfunction after myocardial infarction in dogs
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Hirata A, Minamino T, Asanuma H, Sanada S, Fujita M, Wakeno M, et al. Erythropoietin enhances neovascularization of ischemic myocardium and improves left ventricular dysfunction after myocardial infarction in dogs. Circulation. 2005;112:II-199.
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Effects of erythropoietin on cardiac remodel ing after myocardial infarction
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Nishiya D, Omura T, Shimada K, Matsumoto R, Kusuyama T, Enomoto S, et al. Effects of erythropoietin on cardiac remodel ing after myocardial infarction. J Pharmacol Sci. 2006;101:31-39.
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Erythropoietin induces neovascularization and improves cardiac function in rats with heart failure after myocardial infarction
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Adult vasculogenesis occurs through in situ recruitment, proliferation, and tubulization of circulating bone marrow-derived cells
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Ventricular remodeling after infarction and the extracellular collagen matrix: When is enough enough?
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High serum erythropoietin level is associated with smaller infarct size in patients with acute myocardial infarction who undergo successful primary percutaneous coronary intervention
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Namiuchi S, Kagaya Y, Ohta J, Shiba N, Sugi M, Oikawa M, et al. High serum erythropoietin level is associated with smaller infarct size in patients with acute myocardial infarction who undergo successful primary percutaneous coronary intervention. J Am Coll Cardiol. 2005;45:1406-1412.
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Erythropoietin therapy for acute stroke is both safe and beneficial
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The decision to prematurely terminate a trial of R-HuEPO due to thrombotic events
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Rosenzweig MQ, Bender CM, Lucke JP, Yasko JM, Brufsky AM. The decision to prematurely terminate a trial of R-HuEPO due to thrombotic events. J Pain Symptom Manage. 2004;27:185-190.
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