Pulsatile insulin secretion in elderly patients with diabetes

Diabetes Research and Clinical Practice

Volumn 73, Issue 2, 2006, Pages 218-220

  Meneilly, Graydon S ^a   Veldhuis, Johannes D ^b   Elahi, Dariush ^c  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b MAYO CLINIC   (United States)

^c UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

Diabetes; Elderly; GLP 1; Octreotide; Pulsatile insulin

Indexed keywords

GLUCAGON LIKE PEPTIDE 1; GLUCOSE; HEMOGLOBIN A1C; INSULIN; OCTREOTIDE; TRITIUM;

ADULT; AGED; ARTICLE; BODY MASS; CALCULATION; CHEMICAL LABELING; CLINICAL ARTICLE; CONTROLLED STUDY; DIET RESTRICTION; DISEASE DURATION; DRUG EFFECT; EXPERIMENT; GERIATRIC PATIENT; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLUCOSE CLAMP TECHNIQUE; GLUCOSE METABOLISM; GLUCOSURIA; HUMAN; INSULIN BLOOD LEVEL; INSULIN CLEARANCE; INSULIN METABOLISM; INSULIN RELEASE; LIVER METABOLISM; MEASUREMENT; NON INSULIN DEPENDENT DIABETES MELLITUS;

AGED; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; FASTING; GLUCAGON-LIKE PEPTIDE 1; GLUCOSE CLAMP TECHNIQUE; HUMANS; INSULIN;

EID: 33745286518     PISSN: 01688227     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.diabres.2006.03.014     Document Type: Article

References (12)

1. Meneilly G.S., Ryan A., Veldhuis J., and Elahi D. Increased disorderliness of basal insulin release, attenuated insulin secretory burst mass and reduced ultradian rhythmicity of insulin secretion in older individuals. J. Clin. Endocrinol. Metab. 82 (1997) 4088-4093
2. Meneilly G.S., Veldhuis J., and Elahi D. Disruption of the pulsatile and entropic modes of insulin release during an unvarying glucose stimulus in elderly individuals. J. Clin. Endocrinol. Metab. 84 (1999) 1938-1943
3. Juhl C.B., Schmitz O., Pincus S., Holst J.J., Veldhuis J., and Porksen N. Short term treatment with GLP-1 increased pulsatile insulin secretion in type 2 diabetes with no effect on orderliness. Diabetologia 43 (2000) 583-588
4. Courtney C.H., Atkinson A.B., Ennis C.N., Sheridan B., and Bell P.M. Comparison of the priming effects of pulsatile and continuous insulin delivery on insulin action in man. Metabolism 52 (2003) 1050-1055
5. Ward G.M., Walters J.M., Aitken P.M., Best J.D., and Alford F.P. Effects of prolonged pulsatile hyperinsulinemia in humans: enhancement of insulin sensitivity. Diabetes 39 (1990) 501-507
6. Paolisso G., Sgambato S., Gentile S., et al. Advantageous metabolic effects of pulsatile insulin delivery in noninsulin-dependent diabetic patients. J. Clin. Endocrinol. Metab. 67 (1988) 1005-1010
7. Paolisso G., Scheen A.J., Verdin E.M., Luyckx A.S., and Lefebvre P.J. Insulin oscillations per se do not affect glucose turnover parameters in normal man. J. Clin. Endocrinol. Metab. 63 (1986) 520-525
8. Andres R., Swerdloff R., Pozefsky T., and Coleman D. Manual feedback technique for control of glucose concentration. In: Skeggs Jr. L.T. (Ed). Automation in Analytic Chemistry (1966) 486-501
9. Meneilly G.S., McIntosh C.H.S., Pederson R.A., et al. Glucagon-like peptide -1 (7-37) augments insulin mediated glucose disposal in elderly patients with diabetes. J. Gerontol. 56 (2001) M681-M685
10. Forbes A., Elliott T., Tildesley H., Finegood D., and Meneilly G.S. Alterations in non-insulin medicated glucose uptake in the elderly patient with diabetes. Diabetes 47 (1998) 1915-1919
11. Meneilly G.S., Veldhuis J.D., and Elahi D. Deconvolution analysis of rapid insulin pulses before and after six weeks of continuous subcutaneous administration of GLP-1 in elderly patients with type 2 diabetes. J. Clin. Endocrinol. Metab. 90 (2005) 6251-6256
12. Porksen N., Munn S.R., Steers J.L., Veldhuis J.D., and Butler P.C. Effects of somatostatin on pulsatile insulin secretion: selective inhibition of insulin burst mass. Am. J. Physiol. E270 (1996) 1043-1049