NADP+ Expels both the Co-factor and a Substrate Analog from the Mycobacterium tuberculosis ThyX Active Site: Opportunities for Anti-bacterial Drug Design

Journal of Molecular Biology

Volumn 360, Issue 1, 2006, Pages 1-6

  Sampathkumar, Parthasarathy ^a,b   Turley, Stewart ^a,b   Sibley, Carol Hopkins ^a   Hol, Wim G J ^a,b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

bivalent drugs; flavin; inhibitor design; thymidylate synthase

Indexed keywords

ADENOSINE PHOSPHATE; ANTIINFECTIVE AGENT; BACTERIAL ENZYME; ENZYME INHIBITOR; FLAVINE ADENINE NUCLEOTIDE; NICOTINAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; QUERCETIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TETRAMER; THYMIDINE PHOSPHATE; THYMIDYLATE SYNTHASE; THYMIDYLATE SYNTHASE INHIBITOR;

ARTICLE; BINDING AFFINITY; CATALYSIS; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; DRUG DESIGN; ENZYME ACTIVE SITE; ENZYME ACTIVITY; MOLECULAR INTERACTION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL;

BACTERIA (MICROORGANISMS); MYCOBACTERIUM TUBERCULOSIS;

EID: 33745270753     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2006.04.061     Document Type: Article

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