Mosaicism for mitochondrial DNA polymorphic variants in placenta has implications for the feasibility of prenatal diagnosis in mtDNA diseases

European Journal of Human Genetics

Volumn 14, Issue 7, 2006, Pages 816-823

  Marchington, David R ^a   Scott Brown, Martin ^a   Barlow, David H ^a   Poulton, Joanna ^a  

^a JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

Heteroplasmic mtDNA polymorphisms; Mitochondrial DNA; mtDNA segregation; Placental patch; Prenatal diagnosis

Indexed keywords

MITOCHONDRIAL DNA;

ARTICLE; CHORION VILLUS SAMPLING; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; FETUS; FETUS BLOOD; GENE MUTATION; GENE SEGREGATION; GENETIC VARIABILITY; HETEROPLASMY; HUMAN; MITOCHONDRIAL DNA DISORDER; MOSAICISM; MOTHER; PLACENTA; PRENATAL DIAGNOSIS; PRIORITY JOURNAL; UMBILICAL CORD BLOOD;

CHORIONIC VILLI SAMPLING; DNA, MITOCHONDRIAL; FEMALE; FOUNDER EFFECT; HUMANS; MALE; MITOCHONDRIAL DISEASES; MOSAICISM; PLACENTA; POLYMORPHISM, GENETIC; PREGNANCY; PRENATAL DIAGNOSIS; SEQUENCE ANALYSIS, DNA;

EID: 33745267746     PISSN: 10184813     EISSN: 14765438     Source Type: Journal    
DOI: 10.1038/sj.ejhg.5201618     Document Type: Article

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