Mirtazapine inhibits salivary cortisol concentrations in anorexia nervosa

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 30, Issue 6, 2006, Pages 1015-1019

  Schüle, Cornelius ^a   Sighart, Christian ^a   Hennig, Juergen ^b   Laakmann, Gregor ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

Anorexia nervosa; Cortisol; Mirtazapine; Saliva

Indexed keywords

HYDROCORTISONE; MIRTAZAPINE;

ADULT; ANALYSIS OF VARIANCE; ANOREXIA NERVOSA; ARTICLE; BODY MASS; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; DRUG DOSE REGIMEN; DRUG EFFECT; FEMALE; HAMILTON SCALE; HORMONE DETERMINATION; HOSPITAL ADMISSION; HUMAN; HYPOPHYSIS ADRENAL SYSTEM; SALIVA ANALYSIS; SALIVA LEVEL; SCORING SYSTEM; SINGLE BLIND PROCEDURE; TREATMENT OUTCOME;

ADULT; ANOREXIA NERVOSA; ANTIDEPRESSIVE AGENTS; BODY MASS INDEX; BULIMIA; DATA INTERPRETATION, STATISTICAL; FEMALE; HUMANS; HYDROCORTISONE; MIANSERIN; PSYCHIATRIC STATUS RATING SCALES; SALIVA;

EID: 33745245275     PISSN: 02785846     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pnpbp.2006.03.023     Document Type: Article

References (45)

1. Attia E., Haiman C., Walsh B.T., and Flater S.R. Does fluoxetine augment the inpatient treatment of anorexia nervosa?. Am J Psychiatry 155 (1998) 548-551
2. Baghai T.C., Schule C., Zwanzger P., Minov C., Holme C., Padberg F., Bidlingmaier M., Strasburger C.J., and Rupprecht R. Evaluation of a salivary based combined dexamethasone/CRH test in patients with major depression. Psychoneuroendocrinology 27 (2002) 385-399
3. Barbarich N.C., McConaha C.W., Gaskill J., La Via M., Frank G.K., Achenbach S., Plotnicov K.H., and Kaye W.H. An open trial of olanzapine in anorexia nervosa. J Clin Psychiatry 65 (2004) 1480-1482
4. Bergh C., Eriksson M., Lindberg G., and Sodersten P. Selective serotonin reuptake inhibitors in anorexia. Lancet 348 (1996) 1459-1460
5. Biederman J., Herzog D.B., Rivinus T.M., Harper G.P., Ferber R.A., Rosenbaum J.F., Harmatz J.S., Tondorf R., Orsulak P.J., and Schildkraut J.J. Amitriptyline in the treatment of anorexia nervosa: a double-blind, placebo-controlled study. J Clin Psychopharmacol 5 (1985) 10-16
6. Biller B.M., Saxe V., Herzog D.B., Rosenthal D.I., Holzman S., and Klibanski A. Mechanisms of osteoporosis in adult and adolescent women with anorexia nervosa. J Clin Endocrinol Metab 68 (1989) 548-554
7. Boachie A., Goldfield G.S., and Spettigue W. Olanzapine use as an adjunctive treatment for hospitalized children with anorexia nervosa: case reports. Int J Eat Disord 33 (2003) 98-103
8. Boyar R.M., Hellman L.D., Roffwarg H., Katz J., Zumoff B., O'Connor J., Bradlow H.L., and Fukushima D.K. Cortisol secretion and metabolism in anorexia nervosa. N Engl J Med 296 (1977) 190-193
9. Casper R.C., Chatterton Jr. R.T., and Davis J.M. Alterations in serum cortisol and its binding characteristics in anorexia nervosa. J Clin Endocrinol Metab 49 (1979) 406-411
10. Cooper S.J., and Clifton P.G. Drug receptor subtypes and ingestive behaviour (1996), Academic Press, London 59-97
11. De Boer T. The effects of mirtazapine on central noradrenergic and serotonergic neurotransmission. Int Clin Psychopharmacology 10 Suppl 4 (1995) 19-23
12. Fairburn C.G., and Harrison P.J. Eating disorders. Lancet 361 (2003) 407-416
13. Fassino S., Leombruni P., Daga G., Brustolin A., Migliaretti G., Cavallo F., and Rovera G. Efficacy of citalopram in anorexia nervosa: a pilot study. Eur Neuropsychopharmacol 12 (2002) 453-459
14. Fawcett J., and Barkin R.L. Review of the results from clinical studies on the efficacy, safety and tolerability of mirtazapine for the treatment of patients with major depression. J Affect Disord 51 (1998) 267-285
15. Glowa J.R., and Gold P.W. Corticotropin releasing hormone produces profound anorexigenic effects in the rhesus monkey. Neuropeptides 18 (1991) 55-61
16. Gold P.W., Gwirtsman H., Avgerinos P.C., Nieman L.K., Gallucci W.T., Kaye W., Jimerson D., Ebert M., Rittmaster R., and Loriaux D.L. Abnormal hypothalamic-pituitary-adrenal function in anorexia nervosa. Pathophysiologic mechanisms in underweight and weight-corrected patients. N Engl J Med 314 (1986) 1335-1342
17. Gwirtsman H.E., Kaye W.H., George D.T., Jimerson D.C., Ebert M.H., and Gold P.W. Central and peripheral ACTH and cortisol levels in anorexia nervosa and bulimia. Arch Gen Psychiatry 46 (1989) 61-69
18. Halmi K.A., Eckert E., LaDu T.J., and Cohen J. Anorexia nervosa. Treatment efficacy of cyproheptadine and amitriptyline. Arch Gen Psychiatry 43 (1986) 177-181
19. Hamilton M. A rating scale for depression. J Neurol Neurosurg Psychiatry 23 (1960) 56-62
20. Heinrichs S.C., Menzaghi F., Pich E.M., Baldwin H.A., Rassnick S., Britton K.T., and Koob G.F. Anti-stress action of a corticotropin-releasing factor antagonist on behavioral reactivity to stressors of varying type and intensity. Neuropsychopharmacology 11 (1994) 179-186
21. Hotta M., Shibasaki T., Masuda A., Imaki T., Demura H., Ling N., and Shizume K. The responses of plasma adrenocorticotropin and cortisol to corticotropin-releasing hormone (CRH) and cerebrospinal fluid immunoreactive CRH in anorexia nervosa patients. J Clin Endocrinol Metab 62 (1986) 319-324
22. Hsu L.K. Epidemiology of the eating disorders. Psychiatr Clin North Am 19 (1996) 681-700
23. Kaye W.H., Gwirtsman H.E., George D.T., Ebert M.H., Jimerson D.C., Tomai T.P., Chrousos G.P., and Gold P.W. Elevated cerebrospinal fluid levels of immunoreactive corticotropin-releasing hormone in anorexia nervosa: relation to state of nutrition, adrenal function, and intensity of depression. J Clin Endocrinol Metab 64 (1987) 203-208
24. Kaye W.H., Nagata T., Weltzin T.E., Hsu L.K., Soko l.M.S., McConaha C., Plotnicov K.H., Weise J., and Deep D. Double-blind placebo-controlled administration of fluoxetine in restricting- and restricting-purging-type anorexia nervosa. Biol Psychiatry 49 (2001) 644-652
25. Krahn D.D., Gosnell B.A., Grace M., and Levine A.S. CRF antagonist partially reverses CRF- and stress-induced effects on feeding. Brain Res Bull 17 (1986) 285-289
26. Krahn D.D., Gosnell B.A., Levine A.S., and Morley J.E. Behavioral effects of corticotropin-releasing factor: localization and characterization of central effects. Brain Res 443 (1988) 63-69
27. Laakmann G. Psychopharmaco-endocrinology and depression research. Monogr Gesamtgeb Psychiatr Psychiatry Ser 46 (1988) 1-220
28. Laakmann G., Schule C., Baghai T., and Waldvogel E. Effects of mirtazapine on growth hormone, prolactin, and cortisol secretion in healthy male subjects. Psychoneuroendocrinology 24 (1999) 769-784
29. Laakmann G., Hennig J., Baghai T., and Schule C. Influence of mirtazapine on salivary cortisol in depressed patients. Neuropsychobiology 47 (2003) 31-36
30. Lacey J.H., and Crisp A.H. Hunger, food intake and weight: the impact of clomipramine on a refeeding anorexia nervosa population. Postgrad Med J 56 Suppl 1 (1980) 79-85
31. Licinio J., Wong M.L., and Gold P.W. The hypothalamic-pituitary-adrenal axis in anorexia nervosa. Psychiatry Res 62 (1996) 75-83
32. Misra M., Miller K.K., Almazan C., Ramaswamy K., Lapcharoensap W., Worley M., Neubauer G., Herzog D.B., and Klibanski A. Alterations in cortisol secretory dynamics in adolescent girls with anorexia nervosa and effects on bone metabolism. J Clin Endocrinol Metab 89 (2004) 4972-4980
33. Morley J.E., and Levine A.S. Corticotropin releasing factor, grooming and ingestive behaviour. Life Sci 31 (1982) 1459-1464
34. Putignano P., Dubini A., Toja P., Invitti C., Bonfanti S., Redaelli G., Zappulli D., and Cavagnini F. Salivary cortisol measurement in normal-weight, obese and anorexic women: comparison with plasma cortisol. Eur J Endocrinol 145 (2001) 165-171
35. Rivier C., and Vale W. Influence of corticotropin-releasing factor on reproductive functions in the rat. Endocrinology 114 (1984) 914-921
36. Schule C., Baghai T., Goy J., Bidlingmaier M., Strasburger C., and Laakmann G. The influence of mirtazapine on anterior pituitary hormone secretion in healthy male subjects. Psychopharmacology (Berl) 163 (2002) 95-101
37. Schule C., Baghai T., Rackwitz C., and Laakmann G. Influence of mirtazapine on urinary free cortisol excretion in depressed patients. Psychiatry Res 120 (2003) 257-264
38. Schule C., Baghai T., Schmidbauer S., Bidlingmaier M., Strasburger C.J., and Laakmann G. Reboxetine acutely stimulates cortisol, ACTH, growth hormone and prolactin secretion in healthy male subjects. Psychoneuroendocrinology 29 (2004) 185-200
39. Seed J.A., Dixon R.A., McCluskey S.E., and Young A.H. Basal activity of the hypothalamic-pituitary-adrenal axis and cognitive function in anorexia nervosa. Eur Arch Psychiatry Clin Neurosci 250 (2000) 11-15
40. Sirinathsinghji D.J., Rees L.H., Rivier J., and Vale W. Corticotropin-releasing factor is a potent inhibitor of sexual receptivity in the female rat. Nature 305 (1983) 232-235
41. Sutton R.E., Koob G.F., Le Moal M., Rivier J., and Vale W. Corticotropin releasing factor produces behavioural activation in rats. Nature 297 (1982) 331-333
42. Walsh B.T., Roose S.P., Katz J.L., Dyrenfurth I., Wright L., Van de Wiele R., and Glassman A.H. Hypothalamic-pituitary-adrenal-cortical activity in anorexia nervosa and bulimia. Psychoneuroendocrinology 12 (1987) 131-140
43. Wang TS, Chou YH, Shiah IS, Combined treatment of olanzapine and mirtazapine in anorexia nervosa associated with major depression. Prog. Neuropsychopharmacol. Biol. Psychiatry 2005. [Epub ahead of print].
44. Wiersma A., Baauw A.D., Bohus B., and Koolhaas J.M. Behavioural activation produced by CRH but not alpha-helical CRH (CRH-receptor antagonist) when microinfused into the central nucleus of the amygdala under stress-free conditions. Psychoneuroendocrinology 20 (1995) 423-432
45. Wittchen H.U., Wunderlich U., Zaudig M., and Fydrich T. Strukturiertes Klinisches. Interview für DSM-IV Achse I: Psychische Störungen. Structured clinical interview for DSM-IV, Axis I, German version (1997), Göttingen, Hogrefe