Characteristic dysfunction of stunned myocardium induced by 2,3-butanedione monoxime without ischaemia

Clinical and Experimental Pharmacology and Physiology

Volumn 32, Issue 11, 2005, Pages 968-974

  Wang, X ^a   Guan, X M ^a   Li, G P ^a   Ren, Y ^a   Drzewiecki, G ^b   Li, J K J ^b   Kedem, J ^a  

^a RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^b RUTGERS UNIVERSITY   (United States)

Author keywords

2,3 butanedione monoxime; Contractility; Myocardial stunning; Postischaemic dysfunction

Indexed keywords

DIACETYL OXIME;

ACTIN MYOSIN INTERACTION; ANALYTICAL PARAMETERS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY CIRCUMFLEX BRANCH; DYSKINESIA; FEMALE; FORCE; HEART INFARCTION; HEART MUSCLE; HEART MUSCLE CONTRACTILITY; HEART MUSCLE ISCHEMIA; HEART MUSCLE PERFUSION; HEART MUSCLE REPERFUSION; HYPOTHESIS; LEFT ANTERIOR DESCENDING CORONARY ARTERY; MALE; NONHUMAN; QUANTITATIVE ANALYSIS; STUNNED HEART MUSCLE;

ACETYLCHOLINE; ANIMALS; CORONARY CIRCULATION; DIACETYL; DISEASE MODELS, ANIMAL; DOGS; FEMALE; HEMODYNAMIC PROCESSES; MALE; MYOCARDIAL CONTRACTION; MYOCARDIAL ISCHEMIA; MYOCARDIAL REPERFUSION; MYOCARDIAL STUNNING;

EID: 33745224499     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2005.04292.x     Document Type: Article

References (43)

1. Bolli R. Mechanism of myocardial 'stunning'. Circulation 1990 82 : 723 38.
2. Bolli R Marban E. Molecular and cellular mechanisms of myocardial stunning. Physiol. Rev. 1999 79 : 609 34.
3. Rose J Schulz R Martin C Heusch G. Post-ejection wall thickening as a marker of successful short term hibernation. Cardiovasc. Res. 1993 27 : 1306 11.
4. Ehring T Schulz R Schipke JD Heusch G. Diastolic dysfunction of stunned myocardium. Am. J. Cardiovasc. Pathol. 1993 4 : 358 66.
5. Chiu WC Kedem J Scholz PM Weiss HR. Regional asynchrony of segmental contraction may explain the 'oxygen consumption paradox' in stunned myocardium. Basic Res. Cardiol. 1994 89 : 149 62.
6. Du F Chen XL Drzewiecki G Kedem J. Hypervolaemia improves global and local function and efficiency in postischaemic myocardium. Clin. Exp. Pharmacol. Physiol. 2001 28 : 630 6.
7. Li G Wang X Du F et al. Effects of partial ischaemia and volume loading on myocardial efficiency and cardiac performance in dogs. Cardiovasc. Res. 2002 55 : 122 30.
8. Naim KL Weiss HR Guo X Sadoff J Scholz P Kedem J. Local inotropic stimulation by methylene blue dose not improve mechanical dysfunction due to myocardial stunning. Res. Exp. Med. 1997 197 : 23 35.
9. Li T Sperelakis N Teneick RE Solaro JR. Effects of diacetyl monoxime on cardiac excitation-contraction coupling. J. Pharmacol. Exp. Ther. 1985 323 : 688 96.
10. Blanchard EM Mulieri LA Alpert NR. The effect of 2,3-butanedione monoxime on the relation between initial heat and mechanical output of rabbit pappilary muscle. Biophys. J. 1994 45 : 48A (Abstract).
11. Horiuti K Higuchi H Umasmue Y Konishi M Okasaki O Kurihara A. Mechanism of 2,3-butanedione 2-monoxime on contraction of frog skeletal muscle fibers. J. Muscle Res. Cell Motil. 1988 9 : 156 64.
12. Atoda H Kasuya Y Shigenobu K. Effects of oximes, diacetylmonoxime, pyridine-2-aldoxime, and kyridine-2-aldoxime methochloride, on the electrical and mechanical activities of guinea pig ventricular muscles. J. Pharmacobiodyn. 1985 8 : 425 31.
13. Varma N Eberli FR Apstein CS. Left ventricular diastolic dysfunction during demand ischemia: Rigor underlies increased stiffness without calcium-mediated tension. Amelioration by glycolytic substrate. J. Am. Coll. Cardiol. 2001 37 : 2144 53.
14. Guo X Kedem J Weiss HR Tse J Roistein A Scholz PM. Effects of cyclic GMP reduction on regional myocardial mechanics and metabolism in experimental left ventricular hypertrophy. J. Cardiovasc. Pharmacol. 1996 27 : 392 400.
15. Scholz PM Kedem J Cheinberg BV Weiss HR. The oxygen wasting effect of isoproterenol is altered by chemical denervation and cardiac hypertrophy. Basic Res. Cardiol. 1996 91 : 308 18.
16. Labruno S Naim KL Li JK Drzewiecki G Kedem J. Beta-adrenergic stimulation of reperfusded myocardium following 2-hour ischemia. J. Cardiovasc. Pharmacol. 1998 32 : 535 42.
17. Kloner RA Jennings RB. Consequences of brief ischemia: Stunning, preconditioning, and their clinical implications. Part II. Circulation 2001 104 : 3158 67.
18. Braunwald E Kloner RA. The stunned myocardium: Prolonged, postischemic ventricular dysfunction. Circulation 1982 66 : 1146 9.
19. Heyndrickx GR Millard RW McRitchie RJ et al. Regional myocardial functional and electrophysiological alterations after brief coronary artery occlusion in conscious dogs. J. Clin. Invest. 1975 56 : 978 85.
20. Granger DN. Ischemia-reperfusion: Mechanisms of microvascular dysfunction and the influence of risk factors for cardiovascular disease. Microcirculation 1999 6 : 167 78.
21. Park JL Lucchesi BR. Mechanisms of myocardial reperfusion injury. Ann. Thorac. Surg. 1999 68 : 1905 12.
22. Agati L. Microvascular integrity after reperfusion therapy. Am. Heart. J. 1999 138 ( Suppl. S76 8.
23. Gross GJ Kersten JR Warltier DC. Mechanisms of postischemic contractile dysfunction. Ann. Thorac. Surg. 1999 68 : 1898 04.
24. Jordan JE Zhao ZQ Vinten-Johansen J. The role of neutrophils in myocardial ischemia-reperfusion injury. Cardiovasc. Res. 1999 43 : 860 78.
25. Carden DL Granger DN. Pathophysiology of ischaemia-reperfusion injury. J. Pathol. 2000 190 : 255 66.
26. Verma S Fedak PW Weisel RD et al. Fundamentals of reperfusion injury for the clinical cardiologist. Circulation 2002 105 : 2332 6.
27. Elz JS Nayler WG. Contractile activity and reperfusion-induced calcium gain after ischemia in the isolated rat heart. J. Clin. Invest. 1988 58 : 653 9.
28. Paker CS Kagan ML Kagan JF Robertson SA Stephens NL. The effects of 2,3-butanedione monoxime on smooth muscle mechanical properties. Pflügers Arch. 1988 412 : 659 64.
29. Fryer MF Neering IR Stephenson DG. Effects of 2,3-butanedione monoxime on the contractile activation of fast- and slow-twitch rat muscle fibers. J. Physiol. 1988 407 : 53 75.
30. Higuchi H Takemori S. Butanedione monoxime suppresses contraction and ATPase activity on rabbit skeletal muscle. J. Biochem. 1989 105 : 638 43.
31. Gwathmey JK Hajjar RJ Solaro RJ. Contractile deactivation and uncoupling of crossbridges: Effects of 2,3-butanedione monoxime on mammalian myocardium. Circ. Res. 1991 69 : 1280 92.
32. Garcia-Dorado D Theroux P Duran JM et al. Selective inhibition of the contractile apparatus. Circulation 1992 85 : 1160 74.
33. Buffington CW Strum DP Watanabe S. Regional oxygen consumption persists in dyskinetic canine myocardium. J. Cardiovasc. Pharmacol. 1994 24 : 37 44.
34. Sellin LC McArdle JJ. Multiple effects of 2,3-butanedione monoxime. Pharmacol. Toxicol. 1994 74 : 305 13.
35. Zang WJ Chen LN Yu XJ Fang P Lu J Sun Q. Comparison of effects of acetylcholine on electromechanical characteristics in guinea pig atrium and ventricle. Exp. Physiol. 2005 90 : 123 30.
36. Vatner SF. Correlation between acute reductions in myocardial blood flow and function in conscious dogs. Circ. Res. 1980 47 : 201 7.
37. Gallagher KP Matsuzaki M Koziol JA. Regional myocardial perfusion and wall thickening during ischemia in conscious dogs. Am. J. Physiol. 1984 247 : H727 48.
38. Ross Jr J. Myocardial perfusion-contraction matching. Implications for coronary heart disease and hibernation. Circulation 1991 83 : 1076 83.
39. Suga H Hisano R Hirata S Hayashi T Ninomiya I. Mechanism of higher oxygen consumption rate: Pressure-loaded vs. volume-loaded heart. Am. J. Physiol. 1982 242 : H942 8.
40. Suga H. Ventricular energetics. Annu. Rev. Physiol. 1990 70 : 247 77.
41. Fenn TP. The effect of length on the resting metabolism of muscle. J. Physiol. 1932 74 : 441 5.
42. Berne RM Levy MN. Textbook of Physiology, 4th edn. Mosby, St Louis. 1998.
43. Lu L Xu Y Zhu P Greyson C Schwartz G. A common mechanism for concurrent changes of diastolic muscle length and systolic function in intact hearts. Am. J. Physiol. Heart Circ. Physiol. 2001 280 : H1513 18.