Increased neurofibrillary tangles in the brains of older pedestrians killed in traffic accidents

Dementia and Geriatric Cognitive Disorders

Volumn 22, Issue 1, 2006, Pages 20-26

  Gorrie, C A ^a   Rodriguez, M ^b   Sachdev, P ^a,b   Duflou, J ^b   Waite, P M E ^a  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b PRINCE OF WALES HOSPITAL   (Australia)

Author keywords

Alzheimer's disease; Autopsy pedestrian; Elderly neurofibrillary tangles neuritic plaques

Indexed keywords

AGED; AGING; ARTICLE; AUTOPSY; CAUSE OF DEATH; COGNITIVE DEFECT; COMPARATIVE STUDY; CONTROLLED STUDY; DEMENTIA; FEMALE; FISHER EXACT TEST; HUMAN; HUMAN TISSUE; LEWY BODY; MAJOR CLINICAL STUDY; MALE; NEUROFIBRILLARY TANGLE; NEUROLOGIC EXAMINATION; NEUROPATHOLOGY; PRIORITY JOURNAL; SCORING SYSTEM; TRAFFIC ACCIDENT; VASCULAR LESION;

ACCIDENTS, TRAFFIC; AGED; AGED, 80 AND OVER; BRAIN; CAUSE OF DEATH; CEREBROVASCULAR DISORDERS; DEMENTIA; FEMALE; HUMANS; LEWY BODY DISEASE; MALE; NEUROFIBRILLARY TANGLES; RETROSPECTIVE STUDIES; SENILE PLAQUES;

EID: 33745222118     PISSN: 14208008     EISSN: None     Source Type: Journal    
DOI: 10.1159/000093066     Document Type: Article

References (39)

1. Australian Traffic Safety Bureau: Older pedestrians. Monograph 13. Canberra, Department of Transport and Regional Services, 2002.
2. Organistaion for Economic Co-operation and Development (OECD): Ageing and transport: mobility needs and safety issues. Paris, OECD, 2001.
3. Australian Bureau of Statistics: Australian social trends 1999, population projections: our ageing population. Report No 3101.0. Canberra, Australian Bureau of Statistics, 1999.
4. Friedland R, Koss E, Kumar A, Gaine S, Metzler D, Haxby J, Moore A: Motor vehicle crashes in dementia of the Alzheimer type. Ann Neurol 1988;24:782-786.
5. Drachman DA, Swearer JM, Barnes HJ, Woodward BM, Peterson KE, Moonis M, Weintraub S, Morecroft K, Guinessey J, Acar D, Sandson T, Blass J, Nolan K, Ryan B, Morris JC, Ball LA, Friedland RP, Martin R, Dekosky ST, Fuquawhitley D, Lindeman DA, Castle J: Driving and Alzheimer's disease: the risk of crashes. Neurology 1993;43:2448-2456.
6. Fitten LJ: The demented driver: the doctor's dilemma. Alzheimer Dis Assoc Disord 1997;11(suppl 1):57-61.
7. Rizzo M, McGehee DV, Dawson JD, Anderson SN: Simulated car crashes at intersections in drivers with Alzheimer disease. Alzheimer Dis Assoc Disord 2001;15:10-20.
8. Viitanen M, Johansson K, Bogdanovic N, Berkowicz A, Druid H, Eriksson A, Krantz P, Laaksonen H, Sandler H, Saukko P, Thiblin I, Winblad B, Kalimo H: Alzheimer changes are common in aged drivers killed in single car crashes and at intersections. Forensic Sci Int 1998;96:115-127.
9. Oxley J, Fildes B, Ihsen E, Charlton J, Day R: Differences in traffic judgements between young and old adult pedestrians. Accid Anal Prev 1997;29:839-847.
10. Fildes B, Lee SJ, Kenny D, Foddy W: Survey of older road users. Report No 57. Melbourne, Monash University Accident Research Centre, 1994.
11. Henderson AS, Jorm AF: Dementia in Australia. Report No 35. Canberra, Commonwealth Department of Health and Family Services, 1998.
12. Petersen RC, Doody R, Kurz A, Mohs RC, Morris JC, Rabins PV, Ritchie K, Rossor M, Thai L, Winblad B: Current concepts in mild cognitive impairment. Arch Neurol 2001;58:1985-1992.
13. Hulette CM, Welsh-Bohmer KA, Murray MG, Saunders AM, Mash DC, McIntyre LM: Neuropathological and neuropsychological changes in 'normal' aging: evidence for preclinical Alzheimer disease in cognitively normal individuals. J Neuropathol Exp Neurol 1998;57:1168-1174.
14. Guillozet AL, Weintraub S, Mash DC, Mesulam MM: Neurofibrillary tangles, amyloid and memory in aging and mild cognitive impairment. Arch Neurol 2003;60:729-736.
15. Nagy Z, Esiri MM, Jobst KA, Morris JH, King EM, McDonald B, Litchfield S, Smith A, Barnetson L, Smith AD: Relative roles of plaques and tangles in the dementia of Alzheimer's disease: correlations using three sets of neuropathological criteria. Dementia 1995:21-31.
16. Berg L, McKeel DW Jr, Miller JP, Storandt M, Rubin EH, Morris JC, Baty J, Coats M, Norton J, Goate AM, Price JL, Gearing M, Mirra SS, Saunders AM: Clinicopathologic studies in cognitively healthy aging and Alzheimer's disease: relation of histologic markers to dementia severity, age, sex and apolipoprotein E genotype. Arch Neurol 1998;55:326-335.
17. Grober E, Dickson D, Sliwinski MJ, Buschke H, Katz M, Crystal H, Lipton RB: Memory and mental status correlates of modified Braak staging. Neurobiol Aging 1999;20:573-579.
18. Braak H, Braak E: Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol (Berl) 1991;82:239-259.
19. Mirra SS, Heyman A, McKeel D, Sumi SM, Crain BJ, Brownlee LM, Vogel FS, Hughes JP, van Belle G, Berg L: The consortium to establish a registry for Alzheimer's disease (CERAD). II. Standardization of the neuropathological assessment of Alzheimer's disease. Neurology 1991;41:479-486.
20. The National Institute on Aging and Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer's Disease: Consensus recommendations for the postmortem diagnosis of Alzheimer's disease. Neurobiol Aging 1997;18:S1-S2.
21. McKeith IG, Galasko D, Kosaka K, Perry EK, Dickson DW, Hansen LA, Salmon DP, Lowe J, Mirra SS, Byrne EJ, Lennox G, Quinn NP, Edwardson JA, Ince PG, Bergeron C, Burns A, Miller BL, Lovestone S, Collerton D, Jansen EN, Ballard C, de Vos RA, Wilcock GK, Jellinger KA, Perry RH: Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB). Report of the consortium on DLB international workshop. Neurology 1996;47:1113-1124.
22. Morris JH: Vascular dementia; in Esiri MM, Morris JH (eds): The Neuropathology of Dementia. Cambridge, Cambridge University Press, 1997, pp 137-166.
23. Davis PB, White H, Price JL, Mckneel D, Robins LN: Retrospective postmortem dementia assessment: validation of a new clinical interview to assist neuropathologic study. Arch Neurol 1991;48:613-617.
24. Morris JC: The Clinical Dementia Rating (CDR): current version and scoring rules. Neurology 1993;43:2412-2414.
25. Braak H, Braak E: Frequency of stages of Alzheimer-related lesions in different age categories. Neurobiol Aging 1997;18:351-357.
26. Riley KP, Snowdon DA, Markesbery WR: Alzheimer's neurofibrillary pathology and the spectrum of cognitive function: findings from the Nun Study. Ann Neurol 2002;51:567-577.
27. Duyckaerts C, Hauw JJ: Prevalence, incidence and duration of Braak' s stages in the general population: can we know? Neurobiol Aging 1997;18:362-369.
28. Corder EH, Ghebremedhin E, Taylor MG, Thal DR, Ohm TG, Braak H: The biphasic relationship between regional brain senile plaque and neurofibrillary tangle distributions: modification by age, sex, and APOE polymorphism. Ann NY Acad Sci 2004;1019:24-28.
29. Sandberg G, Stewart W, Smialek J, Troncoso JC: The prevalence of the neuropathological lesions of Alzheimer's disease is independent of race and gender. Neurobiol Aging 2001;22:169-175.
30. Davis DG, Schmitt FA, Wekstein DR, Markesbery WR: Alzheimer neuropathologic alterations in aged cognitively normal subjects. J Neuropathol Exp Neurol 1999;58:376-388.
31. Neuropathology Group of the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS): Pathological correlates of late-onset dementia in a multicentre, community-based population in England and Wales. Lancet 2001;357:169-175.
32. Knopman DS, Parisi JE, Boeve BF, Cha RH, Apaydin H, Salviati A, Edland SD, Rocca WA: Vascular dementia in a population-based autopsy study. Arch Neurol 2003;60:569-575.
33. Price JL, Davis PB, Morris JC, White DL: The distribution of tangles, plaques and related immunohistochemical markers in healthy aging and Alzheimer's disease. Neurobiol Aging 1991;12:295-312.
34. Fitzpatrick AL, Kuller LH, Ives DG, Lopez OL, Jagust W, Breitner JC, Jones B, Lyketsos C, Dulberg C: Incidence and prevalence of dementia in the cardiovascular health study. J Am Geriatr Soc 2004;52:195-204.
35. Yamada T, Hattori H, Miura A, Tanabe M, Yamori Y: Prevalence of Alzheimer's disease, vascular dementia and dementia with Lewy bodies in a Japanese population. Psychiatry Clin Neurosci 2001;55:21-25.
36. Barker WW, Luis CA, Kashuba A, Luis M, Harwood DG, Loewenstein D, Waters C, Jimison P, Shepherd E, Sevush S, Graff-Radford N, Newland D, Todd M, Miller B, Gold M, Heilman K, Doty L, Goodman I, Robinson B, Pearl G, Dickson D, Duara R: Relative frequencies of Alzheimer disease, Lewy body, vascular and frontotemporal dementia, and hippocampal sclerosis in the State of Florida Brain Bank. Alzheimer Dis Assoc Disord 2002;16:203-212.
37. Nath U, Ben-Shlomo Y, Thomson RG, Morris HR, Wood NW, Lees AJ, Burn DJ: The prevalence of progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome) in the UK. Brain 2001;124:1438-1449.
38. Oxley J, Fildes B, de Ihsen E: Older pedestrian safety: the role of perceptual and cognitive factors and the ability to compensate for age-related changes. Proc Road Safety Research, Policing and Education Conference, Brisbane, 2001.
39. Road Safety Committee, Parliament of Victoria: Inquiry into road safety for older road users. Paper No 41. Melbourne, Victorian Government Printer, 2003.