Prenatal vitamin K1 administration in epileptic women to prevent neonatal hemorrhage: Is it fffective?

Journal of Reproductive Medicine for the Obstetrician and Gynecologist

Volumn 51, Issue 6, 2006, Pages 463-466

  Yamasmit, Waralak ^b   Chaithongwongwatthana, Surasith ^b   Tolosa, Jorge E ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b NONE

Author keywords

Epilepsy; Hemorrhagic disease of newborn; Vitamin K1

Indexed keywords

ANTICONVULSIVE AGENT; PHYTOMENADIONE;

ANTICONVULSANT THERAPY; DRUG EFFICACY; EPILEPSY; HUMAN; NEONATAL HEMORRHAGE; NEWBORN HEMORRHAGIC DISEASE; OBSERVATIONAL STUDY; PRENATAL CARE; PRENATAL DRUG EXPOSURE; PRIORITY JOURNAL; PROPHYLAXIS; REVIEW; VITAMIN SUPPLEMENTATION;

ANTICONVULSANTS; ANTIFIBRINOLYTIC AGENTS; EPILEPSY; FEMALE; HEMORRHAGIC DISEASE OF NEWBORN; HUMANS; INFANT, NEWBORN; PREGNANCY; PRENATAL CARE; VITAMIN K 1;

EID: 33745219477     PISSN: 00247758     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (18)

1. Russell AJ, Macpherson H, Cairnie V, et al: The care of pregnant women with epilepsy: A survey of obstetricians in Scotland. Seizure 1996;5:271-277
2. Egenaes J: Outcome of pregnancy in women with epilepsy, Norway 1967-1978: Complications during pregnancy and delivery. In Epilepsy, Pregnancy, and the Child. Edited by D Janz, M Dam, A Richens, et al. New York, Raven Press, 1982, pp 81-85
3. Stoll BJ, Kliegman RM: Blood disorders. In Nelson Textbook of Pediatrics. Seventeenth edition. Edited by RE Behrman, RM Kliegman, HB Jenson. Philadelphia, WB Saunders, 2004, pp 606-607
4. Cornelissen M, Steegers-Theunissen R, Kollee L, et al: Increased incidence of neonatal vitamin K deficiency resulting from maternal anticonvulsant therapy. Am J Obstet Gynecol 1993;168:923-928
5. Bjerkedal T, Bahna SL: The course and outcome of pregnancy in women with epilepsy. Acta Obstet Gynecol Scand 1973;52:245-248
6. Solomon GE, Hilgartner MW, Kutt H: Coagulation defect cause by diphenylhydantoin. Neurology 1972;22:1165-1171
7. Argent AC, Rothberg AD, Pienaar N: Precursor prothrombin status in two mother-infant pairs following gestational anticonvulsant therapy. Pediatr Pharmacol 1984;4:183-187
8. Widershoven J, Lambert W, Motohara K, et al: Plasma concentration of vitamin K and PIVKA II in bottle-fed and breast-fed infants with and without vitamin K prophylaxis at birth. Eur J Pediatr 1988;148:139-142
9. Pietersma-de Bruyn ALJM, van Haard PMM, Beunis MH, et al: Vitamin K1 levels and coagulation factors in healthy term newborns till 4 weeks after birth. Haemostasis 1990;20:8-14
10. Thorp JA, Gaston L, Caspers DR, et al: Current concepts and controversies in the use of vitamin K. Drugs 1995;49:376-387
11. Devinsky O, Yerby MS: Women with epilepsy, reproduction and effects of pregnancy on epilepsy. Neurol Clin 1994;12:479-495
12. Battino D, Granata T, Binelli S, et al: Intrauterine growth in the offspring of epileptic mothers. Acta Neurol Scand 1992;86:555-557
13. Delgado-Escueta AV, Janz D: Consensus guidelines: Preconception counseling, management, and care of the pregnant woman with epilepsy. Neurology (suppl 5) 1992;42:149-160
14. American College of Obstetricians and Gynecologists: Seizure disorders in pregnancy. Int J Gynecol Obstet 1997;56:279-286
15. Howe AM, Oakes DJ, Woodman PD, et al: Prothrombin and PIVKA-II levels in cord blood from newborn exposed to anticonvulsants during pregnancy. Epilepsia 1999;40:980-984
16. Cornelissen M, Steegers-Theunissen R, Kollee L, et al: Supplementation of vitamin K in pregnant women receiving anticonvulsant therapy prevents neonatal vitamin K deficiency. Am J Obstet Gynecol 1993;168:884-888
17. Kaaja E, Kaaja R, Matila R, et al: Enzyme-inducing antiepileptic drugs in pregnancy and the risk of bleeding in the neonate. Neurology 2002;58:549-553
18. Choulika S, Grabowski E, Holmes LB: Is antenatal vitamin K prophylaxis needed for pregnant women taking anticonvulsants? Am J Obstet Gynecol 2004;190:882-883